Manufacturing a thin wire electrostatic trap (TWIST) for ultracold polar molecules

We present a detailed description on how to build a Thin WIre electroStatic Trap (TWIST) for ultracold polar molecules. It is the first design of an electrostatic trap that can be superimposed directly onto a magneto optical trap (MOT). We can thus continuously produce ultracold polar molecules via photoassociation from a two species MOT and instantaneously trap them in the TWIST without the need for complex transfer schemes. Despite the spatial overlap of the TWIST and the MOT, the two traps can be operated and optimized completely independently due to the complementary nature of the utilized trapping mechanisms.Comment: 5 pages, 8 figures, updated conten

Trapping of ultracold polar molecules with a Thin Wire Electrostatic Trap

We describe the realization of a dc electric-field trap for ultracold polar molecules, the thin-wire electrostatic trap (TWIST). The thin wires that form the electrodes of the TWIST allow us to superimpose the trap onto a magneto-optical trap (MOT). In our experiment, ultracold polar NaCs molecules in their electronic ground state are created in the MOT via photoassociation, achieving a continuous accumulation in the TWIST of molecules in low-field seeking states. Initial measurements show that the TWIST trap lifetime is limited only by the background pressure in the chamber.Comment: 4 pages, 3 figure

Formation of ultracold RbCs molecules by photoassociation

The formation of ultracold metastable RbCs molecules is observed in a double species magneto-optical trap through photoassociation below the ^85Rb(5S_1/2)+^133Cs(6P_3/2) dissociation limit followed by spontaneous emission. The molecules are detected by resonance enhanced two-photon ionization. Using accurate quantum chemistry calculations of the potential energy curves and transition dipole moment, we interpret the observed photoassociation process as occurring at short internuclear distance, in contrast with most previous cold atom photoassociation studies. The vibrational levels excited by photoassociation belong to the 5th 0^+ or the 4th 0^- electronic states correlated to the Rb(5P_1/2,3/2)+Cs(6S_1/2) dissociation limit. The computed vibrational distribution of the produced molecules shows that they are stabilized in deeply bound vibrational states of the lowest triplet state. We also predict that a noticeable fraction of molecules is produced in the lowest level of the electronic ground state

Soins ambulatoires et facteurs associés à la réhospitalisation précoce des sujets âgés (65+) après un infarctus du myocarde : étude observationnelle à partir des données nationales de l’Échantillon généraliste de bénéficiaires (EGB)

International audienceÉtat de la questionLes réhospitalisations précoces (RHP), dans les 30jours suivant la sortie d’hospitalisation, sont fréquentes chez les sujets âgés, notamment après un infarctus du myocarde (IDM). Elles augmentent la morbi-mortalité et les dépenses de santé. Il a été démontré qu’une meilleure organisation de la sortie d’hospitalisation réduit significativement le risque de RHP. Néanmoins, il n’existe aucune recommandation sur le suivi ambulatoire en sortie d’hospitalisation. L’objectif de l’étude était d’analyser les soins ambulatoires post-hospitaliers et les facteurs associés à la RHP des sujets âgés après un IDM.Matériel et méthodesÉtude observationnelle rétrospective à partir des données nationales de l’Échantillon généraliste de bénéficiaires (EGB). Tous les patients ≥65 ans, hospitalisés pour un IDM entre 2011 et 2013 étaient inclus. Les patients hospitalisés pour un IDM dans l’année précédente, ou décédés pendant l’hospitalisation initiale ou dans les 30jours suivant la sortie étaient exclus. Le critère de jugement principal était la première réhospitalisation, toutes causes, dans les 30jours suivant la sortie du court-séjour. Des données socio-démographiques, médicales et de soins ambulatoires étaient recueillies. Les déterminants de la RHP étaient identifiés via des modèles de régression logistique.RésultatsParmi les 624 patients éligibles, 137 étaient réhospitalisés dans les 30jours (22 %). L’âge moyen était de 79,2 ans, avec une prédominance masculine (57 %). Le délai moyen de réhospitalisation était de 11,9jours. En analyse multivariée, la fibrillation atriale (OR=1,81 [1,12–2,91]), l’insuffisance rénale chronique (OR=1,90 [1,01–3,57]) et la délivrance d’un antiagrégant plaquettaire ou anticoagulant dans les sept jours suivant la sortie (OR=0,57 [0,38–0,83]) étaient significativement associés à la RHP.ConclusionCette étude, réalisée sur un échantillon représentatif de la population française, confirme le haut risque de RHP chez les sujets âgés en post-IDM. Des interventions ciblées sur les comorbidités et les traitements paraissent nécessaires pour réduire ces RHP

Intramural activation and repolarization sequences in canine ventricles. Experimental and simulation studies

Background: There are no published data showing the three-dimensional sequence of repolarization and the associated potential fields in the ventricles. Knowledge of the sequence of repolarization has medical relevance because high spatial dispersion of recovery times and action potential durations favors cardiac arrhythmias. In this study we describe measured and simulated 3-D excitation and recovery sequences and activation-recovery intervals (ARIs) (measured) or action potential durations (APDs) (simulated) in the ventricular walls. Methods: We recorded from 600 to 1400 unipolar electrograms from canine ventricular walls during atrial and ventricular pacing at 350-450 ins cycle length. Measured excitation and recovery time!; and ARIs were displayed as 2-D maps in transmural planes or 3-D maps in the volume explored, using specially developed software. Excitation and recovery sequences and APD distributions were also simulated in parallelepipedal slabs using anisotropic monodomain or bidomain models based on the Lou-Rudy version I model with homogeneous membrane properties. Results: Simulations showed that in the presence of homogeneous membrane properties, the sequence of repolarization was similar but not identical to the excitation sequence. In a transmural plane perpendicular to epicardial fiber direction, both activation and recovery pathways starting from an epicardial pacing site returned toward the epicardium at a few cm distance from the pacing site. However, APDs were not constant, but had a dispersion of similar to 14 ms in the simulated domain. The maximum APD value was near the pacing site and two minima, appeared along a line perpendicular to fiber directions, passing through the pacing site. Electrical measurements in dog ventricles showed that, for short cycle lengths, both excitation and recovery pathways, starting from an epicardial pacing site, returned toward the epicardium. For slower pacing rates, pathways of recovery departed from the pathway of excitation. Highest ARI values were observed near the pacing site in part of the experiments. fit addition, maps of activation-recovery intervals showed mid-myocardial clusters with activation-recovery intervals that were slightly longer than ARIs closer to the epi- or endocardium, suggesting the presence of M cells in those areas. Transmural dispersion of measured ARIs was on the order of 20-25 ms. Potential distributions during recovery were less affected by myocardial anisotropy than were excitation potentials. (c) 2005 Elsevier Inc. All rights reserved

Intramural activation and repolarization sequences in canine ventricles. Experimental and simulation studies

Background: There are no published data showing the three-dimensional sequence of repolarization and the associated potential fields in the ventricles. Knowledge of the sequence of repolarization has medical relevance because high spatial dispersion of recovery times and action potential durations favors cardiac arrhythmias. In this study we describe measured and simulated 3-D excitation and recovery sequences and activation-recovery intervals (ARIs) (measured) or action potential durations (APDs) (simulated) in the ventricular walls. Methods: We recorded from 600 to 1400 unipolar electrograms from canine ventricular walls during atrial and ventricular pacing at 350-450 ins cycle length. Measured excitation and recovery time!; and ARIs were displayed as 2-D maps in transmural planes or 3-D maps in the volume explored, using specially developed software. Excitation and recovery sequences and APD distributions were also simulated in parallelepipedal slabs using anisotropic monodomain or bidomain models based on the Lou-Rudy version I model with homogeneous membrane properties. Results: Simulations showed that in the presence of homogeneous membrane properties, the sequence of repolarization was similar but not identical to the excitation sequence. In a transmural plane perpendicular to epicardial fiber direction, both activation and recovery pathways starting from an epicardial pacing site returned toward the epicardium at a few cm distance from the pacing site. However, APDs were not constant, but had a dispersion of similar to 14 ms in the simulated domain. The maximum APD value was near the pacing site and two minima, appeared along a line perpendicular to fiber directions, passing through the pacing site. Electrical measurements in dog ventricles showed that, for short cycle lengths, both excitation and recovery pathways, starting from an epicardial pacing site, returned toward the epicardium. For slower pacing rates, pathways of recovery departed from the pathway of excitation. Highest ARI values were observed near the pacing site in part of the experiments. fit addition, maps of activation-recovery intervals showed mid-myocardial clusters with activation-recovery intervals that were slightly longer than ARIs closer to the epi- or endocardium, suggesting the presence of M cells in those areas. Transmural dispersion of measured ARIs was on the order of 20-25 ms. Potential distributions during recovery were less affected by myocardial anisotropy than were excitation potentials. (c) 2005 Elsevier Inc. All rights reserved