Height, Size, and/or Gap Width Variation in Jumping Stone Configurations:Which Form of Variation Attracts Children the Most?

Earlier studies revealed that children prefer nonstandardized jumping stone configurations to standardized ones. In the present study, we examined whether children playing on jumping stones prefer variation in stone height, stone size, and/or gap width. In Experiment 1, children could play freely on one standardized configuration and three configurations in which one of the aforementioned factors was varied. It was found that children judged the variation in height as most fun. Yet, the configuration with gap width variation appeared to be most challenging for the children-most overground steps were made in this configuration. In Experiment 2, we examined whether the attractiveness of the configurations increased when height variation was combined with the other forms of variation. Adding size and/or gap width variation to the variation in height did not contribute to the attractiveness of the configuration. In line with experiment 1, it was found that the configurations with gap width variation were judged as the most challenging for children. The implications of these results are discussed in the context of the literature on play.</p

Lumen - Gaia - Atlas : architectuur, kunst en tuinen van de gebouwen van de Environmental Sciences Group

The Environmental Sciences Group (ESG) is a collaboration between the Wageningen University Department of Environmental Sciences and the research institute Alterra. ESG contributes to realising a relatively high-quality and sustainable green living environment through expert and independent research in the fields of water and climate, soils, landscape, geo-information and ecosystems. This publication describes the architecture of the three buildings and mentions the art products and gardens in and around them

You’re either with us or against us! Moral conviction determines how the politicized distinguish friend from foe

This is the author accepted manuscript. The final version is available from SAGE Publications via the DOI in this recordThree studies investigated how politicized collective identification affects individuals’ reactions towards others. We hypothesized that a strong politicized identity tends to be accompanied by a moral conviction about the politicized cause, which in turn determines how the politicized respond to those less committed to their cause. Consistent with this, Study 1 showed that politicized (feminist) identification is associated with lower identification with women who place moderate (vs. high) moral value on gender equality. Study 2 showed that politicized identification was associated with negative emotions towards people who disagree with this cause and this was mediated by the extent to which participants saw supporting the activist goal as morally obligatory. Study 3 showed that politicized identification, to the extent to which it implied holding a moral conviction about the activist cause, is associated with a desire for more social distance to an attitudinally dissimilar other, but not from an attitudinally similar other.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The research reported in this article was partially funded by a Marie Curie Intra-European Fellowship (328485) awarded to Maarten Zaal

Development of Possible Go-Around Criteria for Transport Aircraft

This paper adds data to help with the development of possible go-around criteria for transport category aircraft. Presently, airline procedures state that pilots make a go-around decision using multiple criteria at 1000 or 500 ft above the ground, or so-called gates. An experiment conducted on three level-D full-flight simulators investigated the conditions from which pilots cannot successfully recover from an unstable approach and make a normal landing. In addition, pilots' perceptions of risk under these various unstable approach conditions and resulting landings were assessed. Six crews, comprised of a captain and a first officer from the same airline, participated in each simulator. Both the captain and the first officer flew approaches and landings from 55 different initial conditions with varying gate heights, localizer deviations, glideslope deviations, reference-speed deviations, and rate of descents. The initial condition at the starting gate mainly affected longitudinal touchdown deviation and rate of descent at touchdown, with reference-speed deviation having the most significant effect. Results show little difference in touchdown performance for conditions from the 300-ft and 500-ft gates. Conditions at the 100-ft gate introduced significant differences in touchdown performance. Reference-speed and localizer deviation at the starting gate had the strongest influences on perceived risk and go-around decision. In line with other studies, these findings suggest that a 300-ft go-around gate might be acceptable. More research is required to investigate the effects of environmental and runway variables before possible go-around criteria for transport category aircraft can be defined

Pilot Evaluation of Proposed Go-Around Criteria for Transport Category Aircraft

The primary objective of this study was to capture pilot feedback and decision-making with regard to proposed, hypothetical, go-around criteria that were developed based on previous research. A secondary objective of the study was to assess crew members' awareness of the aircraft state on approach. An experiment was conducted using Boeing 737-800 and Airbus A330-200 level D full-flight simulators, in which pilots flew multiple approaches which were on the borderline of the proposed go-around criteria at 300 ft. Pilots were instructed that they could either execute a go-around or land the airplane on each run, forcing a decision for the borderline cases at 300 ft. Pilots were instructed to go around if the aircraft was outside of the go-around criteria at 300 ft or if either pilot was uncomfortable with the approach. The results revealed that: 1) the most important factors which drove go-around decision-making during the experiment were airspeed and localizer deviation, 2) the objective data suggested that the 300-ft gate is viable, although many pilots were still uncomfortable with that gate height; perhaps more emphasis on checking stability at 1,000 ft and 500 ft would make more pilots comfortable with the 300-ft go-around gate, 3) allowing for momentary deviations should be considered, and 4) the acceptability of the criteria is highly dependent on given pilot's risk tolerance. Overall, the proposed criteria performed well, and most pilots would find the criteria acceptable with some minor adjustments

Perceiving affordances in sports through a momentum lens

In this experimental study, we tested whether athletes’ judgments of affordances and of environmental features vary with psychological momentum (PM). We recruited golf, hockey, and tennis players, who were assigned to a positive or negative momentum condition. We designed a golf course on which participants made practice putts, after which they were asked to place the ball at their maximum “puttable” distance and to judge the hole size. Next, participants played a golf match against an opponent, in which the first to take a lead of 5 points would win the match. Participants were told that they could win a point by making the putt or by being closest to the hole. They wore visual occlusion goggles to prevent them from seeing the actual result, and the experimenter manipulated the scoring pattern to induce positive or negative PM. Participants in the positive momentum condition came back from a four-point lag to a four-point lead, whereas those in the negative momentum condition underwent the opposite scenario. We then asked the participants again to indicate their maximum puttable distance from the hole and to judge the hole size. After the manipulation, participants judged the maximum puttable distance to be longer in the positive momentum condition and shorter in the negative momentum condition. For the hole-size judgments, there were no significant effects. These results provide first indications for the idea that athletes’ affordances change when they experience positive PM compared to negative PM. This sheds a new light on the dynamics of perception-action processes and PM in sports

Comparison of Transforming Growth Factor 1 (TGF-β1) Expression in Various Lysate Platelet-Rich Fibrin (L-PRF) Concentrations on Human Dental Pulp Stem Cell Differentiation

Objective: To compare Transforming growth factor-β1 (TGF-β1) expression in various L-PRF concentrations on the hDPSC differentiation process. Material and Methods: hDPSC cell cultures were subjected to serum starvation by reducing FBS levels in the hDPSC culture media. Lysate PRF was obtained from the PRF gel, which was then incubated at 4°C for 24 h. The supernatant was dried, transferred to a 2-ml Eppendorf tube, and stored at −20°C. The evaluation of TGF-β1 expression in 1%, 5%, 10%, and 25% L-PRF samples and 10% FBS (control) during the process of hDPSC differentiation was quantified using an ELISA reader on day 7. The expression of TGF-β1 was subjected to a one-way ANOVA test, followed by Bonferroni’s post hoc test with significant values (p&lt;0.05). Results: Significant differences were noted in TGF-β1 expression between 1%, 5%, 10%, and 25% L-PRF and the control group (10% FBS). The highest TGF-β1 expression occurred with 25% L-PRF (0.645 ± 0.048), followed by 10% L-PRF (0.461 ± 0.035), 10% FBS (0.374 ± 0.013), 5% L-PRF (0.275 ± 0.045), and the lowest expression was with 1% L-PRF (0.160 ± 0.045). Conclusion: The best result of TGF-B1 expression in hDPSC differentiation was in the 25% L-PRF group

The Influence of Metabolism on Drug Response in Cancer

Resistance to therapeutic agents, either intrinsic or acquired, is currently a major problem in the treatment of cancers and occurs in virtually every type of anti-cancer therapy. Therefore, understanding how resistance can be prevented, targeted and predicted becomes increasingly important to improve cancer therapy. In the last decade, it has become apparent that alterations in cellular metabolism are a hallmark of cancer cells and that a rewired metabolism is essential for rapid tumor growth and proliferation. Recently, metabolic alterations have been shown to play a role in the sensitivity of cancer cells to widely-used first-line chemotherapeutics. This suggests that metabolic pathways are important mediators of resistance toward anticancer agents. In this review, we highlight the metabolic alterations associated with resistance toward different anticancer agents and discuss how metabolism may be exploited to overcome drug resistance to classical chemotherapy

Physicians' acceptance of pharmacists' interventions in daily hospital practice

Background The physicians' acceptance rate of pharmacists' interventions to improve pharmacotherapy can vary depending on the setting. The acceptance rate of interventions proposed by pharmacists located in the hospital pharmacy over the telephone and factors associated with acceptance are largely unknown. Objective To determine the physicians' acceptance rate of pharmacists' interventions proposed over the telephone in daily hospital practice and to identify factors associated with acceptance. Setting A retrospective case-control study was performed concerning adult patients admitted to a university hospital in the Netherlands. Method Pharmacists' interventions, based on alerts for drug-drug interactions and drug dosing in patients with renal impairment, recorded between January 2012 and June 2013 that were communicated over the telephone were included. Factors associated with physicians' acceptance were identified with the use of a mixed-effects logistic model. Main outcome measure The primary outcome was the proportion of accepted interventions. Results A total of 841 interventions were included. Physicians accepted 599 interventions, resulting in an acceptance rate of 71.2%. The mixed-effects logistic model showed that acceptance was significantly associated with the number of prescribed drugs (16 to ≤ 20 drugs ORadj 1.88; 95% CI 1.05-3.35, > 20 drugs ORadj 2.90; 95% CI 1.41-5.96, compared to ≤ 10 drugs) and the severity of the drug-related problem (problem without potential harm ORadj 6.36; 95% CI 1.89-21.38; problem with potential harm OR 6.78; 95% CI 2.09-21.99, compared to clinically irrelevant problems), and inversely associated with continuation of pre-admission treatment (ORadj 0.55; 95% CI 0.35-0.87). Conclusion Over the study period, the majority of pharmacists' interventions proposed over the telephone were accepted by physicians. The probability for acceptance increased for patients with an increasing number of medication orders, for clinically relevant problems and for problems related to treatment initiated during admission