Estudo da ação citotóxica de drogas antineoplásicas associadas ou não à dexametasona sobre as células de mastocitoma murino (linhagem p-815)

O artigo não apresenta resumo

Anthropometric evaluation and micronutrients intake in patients submitted to laparoscopic Roux-en-Y gastric bypass with a postoperative period of ≥1 year

Backgroung - Bariatric surgery is indicated as the most effective treatment for morbid obesity; the Roux-en-Y gastric bypass (RYGB) is considered the procedure of choice. However, nutritional deficiency may occur in the postoperative period as a result of reduced gastric capacity and change in nutrients absorption in the gastrointestinal tract. The prescription of vitamin and mineral supplementation is a common practice after RYGB; however, it may not be sufficient to prevent micronutrient deficiencies. The aim of this study was to quantify the micronutrient intake in patients undergoing RYGB and verify if the intake of supplementation would be enough to prevent nutritional deficiencies. Methods - The study was conducted on 60 patients submitted to RYGB. Anthropometric, analytical, and nutritional intake data were assessed preoperatively and 1 and 2 years postoperatively. The dietary intake was assessed using 24-h food recall; the values of micronutrients evaluated (vitamin B12, folic acid, iron, and calcium) were compared to the dietary reference intakes (DRI). Results - There were significant differences (p < 0.05) between excess weight loss at the first and second year (69.9 ± 15.3 vs 9.6 ± 62.9 %). In the first and second year after surgery, 93.3 and 94.1 % of the patients, respectively, took the supplements as prescribed. Micronutrient deficiencies were detected in the three evaluation periods. At the first year, there was a significant reduction (p < 0.05) of B12, folic acid, and iron intake. Conclusions - Despite taking vitamin and mineral supplementation, micronutrient deficiencies are common after RYGB. In the second year after surgery, micronutrient intake remains below the DRI

Carboxilatos hidroxilados de rodio II (gluconato, lactobionato e lactato). Síntesis, caracterización y ensayos de citotoxicidad in vitro

The synthesis, characterization and biological assays of two new rhodium carboxy- lates carbohydrate derivatives, rhodium gluconate Rh2(Gli)4 and lactobionate Rh2(Lab)4 are herein described. These compounds showed good water solubility and low toxicity for fe- male mice in dosis higher than 200 mg/kg. The cytostatic activity was carried out in vitro against K-562 cells and compared with other hydroxyl carboxylate, the rhodium lactate Rh2(Lac)4, which was recently described and synthesized in our laboratory by an alternative route. The derivatives showed low in vitro activity but due to the low toxicity they can be considered as promising carboxylate carriers of antineoplasic drugs that can form adducts in the axial positions.Son descritos la sintésis, la caracterización y los ensayos biológicos de dos nuevos Carboxilatos de Rodio derivados de carbohidratos: gluconato y lactobionato de rodio (II). Estos compuestos mostraron una buena solubilidad en agua y baja toxicidad in vivo en rato- nes (hembras) a dosis mayores de 200 mg/kg. La actividad citostática fue evaluada en célu- las K-562 y comparada con otro carboxilato hidroxilado, como el lactato de rodio, Rh2(Lac)4, el cual fue recientemente descrito y sintetizado por una ruta alternativa. La acti- vidad antitumoral de los derivados de carboidratos fue baja, sin embargo por la baja toxici- dad los carboxilatos son prometedores como portadores de fármacos antineoplásicos que puedem formar aductos en posición axial

Imagination for re-engagement from the margins of education

For marginalised secondary school students, mainstream education may no longer appear to be an inviting place. While proposed solutions to problems of disengagement and marginalisation appear to concentrate on finding ways to coerce students back to mainstream education through, for example, ‘learning or earning’ legislation, this article suggests that more effective solutions may be found by engaging with the students in the margins that they occupy. Following discussion of key influences on student disengagement and a theory of imaginations, a ‘students-as-researchers’ (SaR) model of working with young people is discussed to demonstrate that, through the scaffolded application of active imagination, it is possible for such students to identify and create their own connections to the mainstream. The SaR model is illustrated through reference to groups of disaffected high school students who participated in an action research project to investigate apparent low aspiration for tertiary education among their peers at schools serving low-income communities in Queensland, Australia

Relevant, challenging, integrative and exploratory curriculum design: perspectives from theory and practice for middle schooling in Australia

Integrative curriculum design, or student-centred curriculum integration, promises much for middle grades teachers wishing to develop classroom programmes that will encourage early adolescents to actively engage in their learning (Beane 1990, 1997). Integrative designs are highly responsive to the educational and developmental needs of young people. In contrast, student-centred multidisciplinary curriculum designs (Jacobs 1989) may result in significant but largely unrecognised drawbacks when they are applied to the middle grades. This paper critically examines the integrative and the multidisciplinary models of curriculum integration with respect to the educational and developmental needs of students in the middle grades. It draws its data from a doctoral study that traced a century of development of curriculum integration in the USA: from John Dewey's Laboratory School a century ago through to contemporary middle schools

Knowledge and enterprises in developing countries: evidences from Chile

ABSTRACT: Knowledge management is a fundamental tool in order to obtain competitive advantages in organizations. In this paper, we present an interesting study about how enterprises in a developing country like Chile manage their knowledge by using variables linked with three interesting concepts related to knowledge: innovation, learning, and knowledge sharing. From this information, six clusters of enterprises and two special cases with different behaviors in knowledge management and different results are identified. From this information, some conclusions are extracted: (1) clusters 4 and 5 are the best in knowledge management (best results) and, thus, other enterprises should replicate their behaviors; (2) the Government of Chile should promote more knowledge management in order to improve the country’s performance; (3) chemical industry is highlighted like one of the most important one related to knowledge; and finally, (4) enterprises with a high investment in knowledge are also enterprises with high results. These results are very interesting in order to understand the knowledge activity in a developing country like Chile.The authors thank to Ministerio de Ciencia e Innovación (project ECO2010-15455) for partial support of this work