Set of Boundary Conditions for Aerodynamic Design

Robust and flexible numerical methodologies for the imposition of boundary conditions are required to formulate well-posed problems. A boundary condition should be Robust and flexible numerical methodologies for the imposition of boundary conditions are required to formulate well-posed problems. A boundary condition should be nonreflecting, to avoid spurious perturbations that can provocate unsteadiness or instabilities. The reflectiveness of various boundary conditions is analyzed in the context of the Godunov methods. A nonlinear, isentropic wave propagation model is used to investigate the reflection mechanism on the flowfield borders, and a parameter τ is defined to give a measure of the boundary reflectiveness. A new set of boundary conditions, in which τ =0, that is, totally nonreflecting, is then proposed. The approach has been integrated in an aerodynamic design procedure using a distributed boundary control

Scaling Behavior of Response Functions in the Coarsening Dynamics of Disordered Ferromagnets

We study coarsening dynamics in the ferromagnetic random bond Ising model in d = 1; 2. We focus on the validity of super-universality and the scaling properties of the response functions. In the d = 1 case, we obtain a complete understanding of the evolution, from pre- asymptotic to asymptotic behavior. The corresponding response function shows a clear violation of super-universality. Further, our results for d = 1; 2 settle the controversy regarding the decay exponent which characterizes the response function

Control of the urban pigeon Columba livia population and the preservation of common swift Apus apus and bats Chiroptera during the restoration of the Ghirlandina tower in the city of Modena (Italy)

Ferri, M., Ferraresi, M., Gelati, A., Zannetti, G., Domenichini, A., Ravizza, L., Cadignani, R

Development and testing of a new instrument to measure self-care in patients with osteoporosis: the self-care of osteoporosis scale

Purpose: The aim of this study was to develop and test the Self-Care of Osteoporosis Scale (SCOS), a new instrument to measure self-care in postmenopausal women with osteoporosis. Methods: A cross-sectional study was conducted. The SCOS was developed by a panel of experts and it was theory-driven. Confirmatory factor analysis (N = 544) was used to test the instrument’s factorial validity; Cronbach’s alpha and McDonald’s omega were used to derive the measure’s internal consistency reliability; an intraclass correlation coefficient was used to evaluate test-retest reliability. Results: Confirmatory factor analysis resulted in supportive fit indices for the hypothesized three-factor structure of the SCOS (RMSEA = 0.065; CFI = 0.99). The SCOS was demonstrated to have content validity, internal consistency and test-retest reliability. Conclusions: The SCOS demonstrated excellent psychometric characteristics in terms of validity and reliability. It may be used by healthcare providers to identify if patients show lower self-care and require educational interventions

Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRβ Aptamer

Bone marrow-derived mesenchymal stem cells (BM-MSCs) are shown to participate in tumor progression by establishing a favorable tumor microenvironment (TME) that promote metastasis through a cytokine networks. However, the mechanism of homing and recruitment of BM-MSCs into tumors and their potential role in malignant tissue progression is poorly understood and controversial. Here we show that BM-MSCs increase aggressiveness of triple-negative breast cancer (TNBC) cell lines evaluated as capability to migrate, invade and acquire stemness markers. Importantly, we demonstrate that the treatment of BM-MSCs with a nuclease-resistant RNA aptamer against platelet-derived growth factor receptor β (PDGFRβ) causes the inhibition of receptor-dependent signaling pathways thus drastically hampering BM-MSC recruitment towards TNBC cell lines and BM-MSCs trans-differentiation into carcinoma-associated fibroblast (CAF)-like cells. Moreover, in vivo molecular imaging analysis demonstrated the aptamer ability to prevent BM-MSCs homing to TNBC xenografts. Collectively, our results indicate the anti-PDGFRβ aptamer as a novel therapeutic tool to interfere with BM-MSCs attraction to TNBC providing the rationale to further explore the aptamer in more complex pre-clinical settings

Fluctuation-Dissipation relations far from Equilibrium

In this Article we review some recent progresses in the field of non-equilibrium linear response theory. We show how a generalization of the fluctuation-dissipation theorem can be derived for Markov processes, and discuss the Cugliandolo-Kurchan \cite{Cugliandolo93} fluctuation dissipation relation for aging systems and the theorem by Franz {\it et. al.} \cite{Franz98} relating static and dynamic properties. We than specialize the subject to phase-ordering systems examining the scaling properties of the linear response function and how these are determined by the behavior of topological defects. We discuss how the connection between statics and dynamics can be violated in these systems at the lower critical dimension or as due to stochastic instability.Comment: 18 pages, 10 figure

Scaling and Crossover in the Large-N Model for Growth Kinetics

The dependence of the scaling properties of the structure factor on space dimensionality, range of interaction, initial and final conditions, presence or absence of a conservation law is analysed in the framework of the large-N model for growth kinetics. The variety of asymptotic behaviours is quite rich, including standard scaling, multiscaling and a mixture of the two. The different scaling properties obtained as the parameters are varied are controlled by a structure of fixed points with their domains of attraction. Crossovers arising from the competition between distinct fixed points are explicitely obtained. Temperature fluctuations below the critical temperature are not found to be irrelevant when the order parameter is conserved. The model is solved by integration of the equation of motion for the structure factor and by a renormalization group approach.Comment: 48 pages with 6 figures available upon request, plain LaTe

Early stage scaling in phase ordering kinetics

A global analysis of the scaling behaviour of a system with a scalar order parameter quenched to zero temperature is obtained by numerical simulation of the Ginzburg-Landau equation with conserved and non conserved order parameter. A rich structure emerges, characterized by early and asymptotic scaling regimes, separated by a crossover. The interplay among different dynamical behaviours is investigated by varying the parameters of the quench and can be interpreted as due to the competition of different dynamical fixed points.Comment: 21 pages, latex, 7 figures available upon request from [email protected]

Condensation vs. phase-ordering in the dynamics of first order transitions

The origin of the non commutativity of the limits $t \to \infty$ and $N \to \infty$ in the dynamics of first order transitions is investigated. In the large-N model, i.e. $N \to \infty$ taken first, the low temperature phase is characterized by condensation of the large wave length fluctuations rather than by genuine phase-ordering as when $t \to \infty$ is taken first. A detailed study of the scaling properties of the structure factor in the large-N model is carried out for quenches above, at and below T_c. Preasymptotic scaling is found and crossover phenomena are related to the existence of components in the order parameter with different scaling properties. Implications for phase-ordering in realistic systems are discussed.Comment: 15 pages, 13 figures. To be published in Phys. Rev.

Overall time evolution in phase-ordering kinetics

The phenomenology from the time of the quench to the asymptotic behavior in the phase-ordering kinetics of a system with conserved order parameter is investigated in the Bray-Humayun model and in the Cahn-Hilliard-Cook model. From the comparison of the structure factor in the two models the generic pattern of the overall time evolution, based on the sequence ``early linear - intermediate mean field - late asymptotic regime'' is extracted. It is found that the time duration of each of these regimes is strongly dependent on the wave vector and on the parameters of the quench, such as the amplitude of the initial fluctuations and the final equilibrium temperature. The rich and complex crossover phenomenology arising as these parameters are varied can be accounted for in a simple way through the structure of the solution of the Bray-Humayun model.Comment: RevTeX, 14 pages, 18 figures, to appear in Phys. Rev.