Hierarchical Joint Registration of Tissue Blocks With Soft Shape Constraints For Large-Scale Histology of The Human Brain

Large-scale 3D histology reconstruction of the human brain with MRI as volumetric reference generally requires reassembling the tissue blocks into the MRI space, prior to any further reconstruction of the histology of the individual blocks. This is a challenging registration problem, particularly in the frequent case that blockface photographs of paraffin embedded tissue are used as intermediate modality, as their contrast between white and gray matter is rather low. Here we propose a registration framework to address this problem, relying on two key components. First, blocks are simultaneously aligned to the MRI while exploiting the spatial constraints that they impose on each other, by means of a customized soft shape constraint (similarly to a jigsaw puzzle). And second, we adopt a hierarchical optimization strategy that capitalizes on our prior knowledge on the slicing and blocking procedure. Our framework is validated quantitatively on synthetic data, and qualitatively on the histology of a whole human hemisphere

Degradation of polycrystalline HfO2-based gate dielectrics under nanoscale electrical stress

The evolution of the electrical properties of HfO2/SiO2/Si dielectric stacks under electrical stress has been investigated using atomic force microscope-based techniques. The current through the grain boundaries (GBs), which is found to be higher than thorough the grains, is correlated to a higher density of positively charged defects at the GBs. Electrical stress produces different degradation kinetics in the grains and GBs, with a much shorter time to breakdown in the latter, indicating that GBs facilitate dielectric breakdown in high-k gate stacks

Origin of the reduced exchange bias in epitaxial FeNi(111)/CoO(111) bilayer

We have employed Soft and Hard X-ray Resonant Magnetic Scattering and Polarised Neutron Diffraction to study the magnetic interface and the bulk antiferromagnetic domain state of the archetypal epitaxial Ni$_{81}$Fe$_{19}$(111)/CoO(111) exchange biased bilayer. The combination of these scattering tools provides unprecedented detailed insights into the still incomplete understanding of some key manifestations of the exchange bias effect. We show that the several orders of magnitude difference between the expected and measured value of exchange bias field is caused by an almost anisotropic in-plane orientation of antiferromagnetic domains. Irreversible changes of their configuration lead to a training effect. This is directly seen as a change in the magnetic half order Bragg peaks after magnetization reversal. A 30 nm size of antiferromagnetic domains is extracted from the width the (1/2 1/2 1/2) antiferromagnetic magnetic peak measured both by neutron and x-ray scattering. A reduced blocking temperature as compared to the measured antiferromagnetic ordering temperature clearly corresponds to the blocking of antiferromagnetic domains. Moreover, an excellent correlation between the size of the antiferromagnetic domains, exchange bias field and frozen-in spin ratio is found, providing a comprehensive understanding of the origin of exchange bias in epitaxial systems.Comment: 8 pages, 5 figures, submitte

Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L

Ribosome-inactivating proteins (RIPs) are known as RNA N-glycosylases. They depurinate the major rRNA, damaging ribosomes and inhibiting protein synthesis. Here, new single-chain (type-1) RIPs named sodins were isolated from the seeds (five proteins), edible leaves (one protein) and roots (one protein) of Salsola soda L. Sodins are able to release Endo’s fragment when incubated with rabbit and yeast ribosomes and inhibit protein synthesis in cell-free systems (IC50 = 4.83–79.31 pM). In addition, sodin 5, the major form isolated from seeds, as well as sodin eL and sodin R, isolated from edible leaves and roots, respectively, display polynucleotide:adenosine glycosylase activity and are cytotoxic towards the Hela and COLO 320 cell lines (IC50 = 0.41–1200 nM), inducing apoptosis. The further characterization of sodin 5 reveals that this enzyme shows a secondary structure similar to other type-1 RIPs and a higher melting temperature (Tm = 76.03 ± 0.30 °C) and is non-glycosylated, as other sodins are. Finally, we proved that sodin 5 possesses antifungal activity against Penicillium digitatum

Kondo lattice model with a direct exchange interaction between localized moments

We study the Kondo lattice model with a direct antiferromagnetic exchange interaction between localized moments. Ferromagnetically long-range ordered state coexisting with the Kondo screening shows a continuous quantum phase transition to the Kondo singlet state. We obtain the value of the critical point where the magnetizations of the localized moments and the conduction electrons vanish. The magnetization curves yield a universal critical exponent independent of the filling factors and the strength of the interaction between localized moments. It is shown that the direct exchange interaction between localized moments introduces another phase transition from an antiferromagnetic ordering to a ferromagnetic ordering for small Kondo exchange interaction. We also explain the local minimum of the Kondo temperature in recent experiments.Comment: 6 pages, 5 figures, final versio

The Self-Accelerating Universe with Vectors in Massive Gravity

We explore the possibility of realising self-accelerated expansion of the Universe taking into account the vector components of a massive graviton. The effective action in the decoupling limit contains an infinite number of terms, once the vector degrees of freedom are included. These can be re-summed in physically interesting situations, which result in non-polynomial couplings between the scalar and vector modes. We show there are self-accelerating background solutions for this effective action, with the possibility of having a non-trivial profile for the vector fields. We then study fluctuations around these solutions and show that there is always a ghost, if a background vector field is present. When the background vector field is switched off, the ghost can be avoided, at the price of entering into a strong coupling regime, in which the vector fluctuations have vanishing kinetic terms. Finally we show that the inclusion of a bare cosmological constant does not change the previous conclusions and it does not lead to a ghost mode in the absence of a background vector field.Comment: 23 pages, 2 figure

The graded Jacobi algebras and (co)homology

Jacobi algebroids (i.e. `Jacobi versions' of Lie algebroids) are studied in the context of graded Jacobi brackets on graded commutative algebras. This unifies varios concepts of graded Lie structures in geometry and physics. A method of describing such structures by classical Lie algebroids via certain gauging (in the spirit of E.Witten's gauging of exterior derivative) is developed. One constructs a corresponding Cartan differential calculus (graded commutative one) in a natural manner. This, in turn, gives canonical generating operators for triangular Jacobi algebroids. One gets, in particular, the Lichnerowicz-Jacobi homology operators associated with classical Jacobi structures. Courant-Jacobi brackets are obtained in a similar way and use to define an abstract notion of a Courant-Jacobi algebroid and Dirac-Jacobi structure. All this offers a new flavour in understanding the Batalin-Vilkovisky formalism.Comment: 20 pages, a few typos corrected; final version to be published in J. Phys. A: Math. Ge

Inelastically scattering particles and wealth distribution in an open economy

Using the analogy with inelastic granular gasses we introduce a model for wealth exchange in society. The dynamics is governed by a kinetic equation, which allows for self-similar solutions. The scaling function has a power-law tail, the exponent being given by a transcendental equation. In the limit of continuous trading, closed form of the wealth distribution is calculated analytically.Comment: 8 pages 5 figure

Combination of Persistent Scatterer Interferometry and Single-Baseline Polarimetric Coherence Optimisation to Estimate Deformation Rates with Application to Tehran Basin

This study reports on the monitoring of land subsidence in a rural area located in the southwest of the Tehran basin, Iran, by combining a persistent scatterer interferometry (PSI) method with a single-baseline polarimetric coherence optimisation. Owing to vegetation coverage in this rural area, coherence level experiences a decline and the performance and coverage of conventional interferometry to estimate deformation rate reduces concomitantly. Since the launch of satellites with polarimetric information, the polarimetric InSAR (PolInSAR) technique, which is vector interferometry with different polarimetric channels, has been introduced to optimise the coherence level. One of the most common criteria to select PS pixels is coherence and maximising the coherence can lead to an increased number of selected PS pixels and enhanced PSI performance. The single-baseline polarimetric coherence optimisation method assumes equal polarisation states at the end of each baseline. In order to apply this technique in our study, two different multi-look windows for coherence calculation and also two TerraSAR-X data sets with different numbers of images are used to assess their effect on the polarimetric PSI. Combination of the single-baseline coherence optimisation method with PSI shows significant improvements (more than 50%) in terms of the number of selected PS pixels in the case study even using a data set with a small number of images. A 15 × 15 multi-look window selects a greater number of PS pixels compared to a 9×9 multi-look window, although this entails reducing spatial resolution. The most effective PSI approach in terms of the density of the selected PS turned out to be polarimetric PSI using a data set with a large number of images and a selection of a 15 × 15 multi-look window. Validation of the PSI methods using a large number of images with 9×9 and 15 × 15 multi-look windows via levelling measurements confirms the accuracy and reliability of the results obtained