A framework for extracting and representing project knowledge contexts using topic models and dynamic knowledge maps

There is still a lack of effective paradigms and tools for analysing and discovering the contents and relationships of project knowledge contexts in the field of project management. In this paper, a new framework for extracting and representing project knowledge contexts using topic models and dynamic knowledge maps under big data environments is proposed and developed. The conceptual paradigm, theoretical underpinning, extended topic model, and illustration examples of the ontology model for project knowledge maps are presented, with further research work envisaged

Saluran Pemasaran Cabai Merah (Capsicum Annum L.) (suatu Kasus di Desa Sukamaju Kecamatan Cihaurbeuti Kabupaten Ciamis)

Penelitian ini bertujuan untuk mengetahui : (1) Saluran pemasaran Cabai Merah di Desa Sukamaju Kecamatan Cihaurbeuti Kabupaten Ciamis; (2) Besarnya biaya dan keuntungan pemasaran Cabai Merah di Desa Sukamaju Kecamatan Cihaurbeuti Kabupaten Ciamis; (3) Besarnya marjin pemasaran Cabai Merah untuk setiap tingkatan lembaganya; (4) Besarnya bagian harga yang diterima petani keseluruhan harga yang di bayar oleh konsumen; Jenis penelitian yang digunakan dalam penelitian ini adalah studi kasus. Dimana penelitiandilakukan dalam ruang alamiah atau bukan buatan dan penelitian melakukan perlakuan dalam pengumpulan data. Sampel yang sebagian diambil dari keseluruhan objek yang diteliti dan dianggap mewakili seluruh populasi. Sampel pada penelitian ini yaitu seluruh petani Cabai Merah di Desa Sukamaju sebanyak 30 orang, pedagang pengumpul 2 orang, pedagang besar 1 orang dankonsumen pengecer 25 orang.1) Saluran pemasaran Saluran Pemasaran I: Petani-Pedagang Pengumpul-Pedagang Pengecer-KonsumenSaluran Pemasaran II: Petani-Pedagang-Pedagang Besar-Pedagang Pengecer-Konsumen2) Biaya pemasaran pada saluran pemasaran I sebesar Rp 272,00 per kilogram dan saluran pemasaran II sebesar Rp 629,78 per kilogram. Keuntungan pemasaran pada saluran pemasaran I sebesar Rp 4,100,00 per kilogram dan saluran pemasaran II sebesar Rp 5,400,00 per kilogram.3) Marjin pemasaran pada saluran pemasaran I sebesar Rp 4.372,00 per kilogram dan saluran pemasaran II sebesar Rp 5.682,00 per kilogram.4) Farmers share atau bagian harga yang diterima petani pada saluran pemasaran I adalah 73,5 persen dan saluran pemasaran II adalah 64,7 persen dari harga yang dibayarkan konsumen

Development of higher education model in china under covid-19

The epidemic has had a profound impact on China's higher education, which will change the current education model of colleges and universities and make the advantages of information-based teaching more obvious. The flexibility of online education plays an important role in adapting to the changing environment and diversified educational methods. The combination of online education and school education will lay a foundation for the exploration of future education models

Development of higher education model in china under covid-19

The epidemic has had a profound impact on China's higher education, which will change the current education model of colleges and universities and make the advantages of information-based teaching more obvious. The flexibility of online education plays an important role in adapting to the changing environment and diversified educational methods. The combination of online education and school education will lay a foundation for the exploration of future education models

Emerging Priorities for Microbiome Research

Microbiome research has increased dramatically in recent years, driven by advances in technology and significant reductions in the cost of analysis. Such research has unlocked a wealth of data, which has yielded tremendous insight into the nature of the microbial communities, including their interactions and effects, both within a host and in an external environment as part of an ecological community. Understanding the role of microbiota, including their dynamic interactions with their hosts and other microbes, can enable the engineering of new diagnostic techniques and interventional strategies that can be used in a diverse spectrum of fields, spanning from ecology and agriculture to medicine and from forensics to exobiology. From June 19–23 in 2017, the NIH and NSF jointly held an Innovation Lab on Quantitative Approaches to Biomedical Data Science Challenges in our Understanding of the Microbiome. This review is inspired by some of the topics that arose as priority areas from this unique, interactive workshop. The goal of this review is to summarize the Innovation Lab’s findings by introducing the reader to emerging challenges, exciting potential, and current directions in microbiome research. The review is broken into five key topic areas: (1) interactions between microbes and the human body, (2) evolution and ecology of microbes, including the role played by the environment and microbe-microbe interactions, (3) analytical and mathematical methods currently used in microbiome research, (4) leveraging knowledge of microbial composition and interactions to develop engineering solutions, and (5) interventional approaches and engineered microbiota that may be enabled by selectively altering microbial composition. As such, this review seeks to arm the reader with a broad understanding of the priorities and challenges in microbiome research today and provide inspiration for future investigation and multi-disciplinary collaboration

Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering

In nature, specific biomolecules interacting with mineral precursors are responsible for the precise production of nanostructured inorganic materials that exhibit complex morphologies and superior performance. Despite advances in developing biomimetic approaches, the design rules for creating sequence-defined molecules that lead to the synthesis of inorganic nanomaterials with predictable complex morphologies are unknown. Herein we report the design of sequence-defined peptoids for controlled synthesis of highly branched plasmonic gold particles. By engineering peptoid sequences and investigating the resulting particle formation mechanisms, we develop a rule of thumb for designing peptoids that predictively enabled the morphological evolution from spherical to coral-shaped nanoparticles. Through a combination of hyperspectral UV-Vis extinction microscopy and three-photon photoemission electron microscopy, we demonstrate that the individual coral-shaped gold nanoparticles exhibit a plasmonic enhancement as high as 105-fold. This research significantly advances our ultimate vision of predictive bio-inspired materials synthesis using sequence-defined synthetic molecules that mimic proteins and peptides

A Novel Small Molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose Mimics the Antiplatelet Actions of Insulin

BACKGROUND: We have shown that 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose (α-PGG), an orally effective hypoglycemic small molecule, binds to insulin receptors and activates insulin-mediated glucose transport. Insulin has been shown to bind to its receptors on platelets and inhibit platelet activation. In this study we tested our hypothesis that if insulin possesses anti-platelet properties then insulin mimetic small molecules should mimic antiplatelet actions of insulin. PRINCIPAL FINDINGS: Incubation of human platelets with insulin or α-PGG induced phosphorylation of insulin receptors and IRS-1 and blocked ADP or collagen induced aggregation. Pre-treatment of platelets with α-PGG inhibited thrombin-induced release of P-selectin, secretion of ATP and aggregation. Addition of ADP or thrombin to platelets significantly decreased the basal cyclic AMP levels. Pre-incubation of platelets with α-PGG blocked ADP or thrombin induced decrease in platelet cyclic AMP levels but did not alter the basal or PGE(1) induced increase in cAMP levels. Addition of α-PGG to platelets blocked agonist induced rise in platelet cytosolic calcium and phosphorylation of Akt. Administration of α-PGG (20 mg kg(-1)) to wild type mice blocked ex vivo platelet aggregation induced by ADP or collagen. CONCLUSIONS: These data suggest that α-PGG inhibits platelet activation, at least in part, by inducing phosphorylation of insulin receptors leading to inhibition of agonist induced: (a) decrease in cyclic AMP; (b) rise in cytosolic calcium; and (c) phosphorylation of Akt. These findings taken together with our earlier reports that α-PGG mimics insulin signaling suggest that inhibition of platelet activation by α-PGG mimics antiplatelet actions of insulin