1,702 research outputs found
Development of sustainable biodegradable lignocellulosic hemp fiber/polycaprolactone biocomposites for light weight applications
Biocomposites with poly(ε-caprolactone) (PCL) as matrix and lignocellulosic hemp fiber with varying average aspect ratios (19, 26, 30 and 38) as reinforcement were prepared using twin extrusion process. The influence of fiber aspect ratio on the water absorption behavior and mechanical properties are investigated. The percentage of moisture uptake increased with the aspect ratio, following Fickian behavior. The hemp fiber/PCL biocomposites showed enhanced properties (tensile, flexural and low-velocity impact). The biocomposite with 26 aspect ratio showed the optimal properties, with flexural strength and modulus of 169% and 285% respectively, higher than those of neat PCL. However, a clear reduction on the mechanical properties was observed for water-immersed samples, with reduction in tensile and flexural moduli for the aspect ratio of 26 by 90% and 62%, respectively than those of dry samples. Summarily, the optimal sample provides an eco-friendly alternative to conventional, petroleum-based and non-renewable composites for various applications.Peer reviewedFinal Accepted Versio
Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.
Private specificities of CD8 T cell responses control patterns of heterologous immunity
CD8 T cell cross-reactivity between viruses can play roles in protective heterologous immunity and damaging immunopathology. This cross-reactivity is sometimes predictable, such as between lymphocytic choriomeningitis virus (LCMV) and Pichinde virus, where cross-reactive epitopes share six out of eight amino acids. Here, however, we demonstrate more subtle and less predictable cross-reactivity between LCMV and the unrelated vaccinia virus (VV). Epitope-specific T cell receptor usage differed between individual LCMV-infected C57BL/6 mice, even though the mice had similar epitope-specific T cell hierarchies. LCMV-immune mice challenged with VV showed variations, albeit in a distinct hierarchy, in proliferative expansions of and down-regulation of IL-7Rα by T cells specific to different LCMV epitopes. T cell responses to a VV-encoded epitope that is cross-reactive with LCMV fluctuated greatly in VV-infected LCMV-immune mice. Adoptive transfers of splenocytes from individual LCMV-immune donors resulted in nearly identical VV-induced responses in each of several recipients, but responses differed depending on the donor. This indicates that the specificities of T cell responses that are not shared between individuals may influence cross-reactivity with other antigens and play roles in heterologous immunity upon encounter with another pathogen. This variability in cross-reactive T cell expansion that is unique to the individual may underlie variation in the pathogenesis of infectious diseases
Application of Volcano Plots in Analyses of mRNA Differential Expressions with Microarrays
Volcano plot displays unstandardized signal (e.g. log-fold-change) against
noise-adjusted/standardized signal (e.g. t-statistic or -log10(p-value) from
the t test). We review the basic and an interactive use of the volcano plot,
and its crucial role in understanding the regularized t-statistic. The joint
filtering gene selection criterion based on regularized statistics has a curved
discriminant line in the volcano plot, as compared to the two perpendicular
lines for the "double filtering" criterion. This review attempts to provide an
unifying framework for discussions on alternative measures of differential
expression, improved methods for estimating variance, and visual display of a
microarray analysis result. We also discuss the possibility to apply volcano
plots to other fields beyond microarray.Comment: 8 figure
JAMILA: A Usable Batch Job Management System to Coordinate Heterogeneous Clusters and Diverse Applications over Grid or Cloud Infrastructure
A Search for Hierarchical Triples using Kepler Eclipse Timing
We present the first results of a Kepler survey of 41 eclipsing binaries that
we undertook to search for third star companions. Such tertiaries will
periodically alter the eclipse timings through light travel time and dynamical
effects. We discuss the prevalence of starspots and pulsation among these
binaries and how these phenomena influence the eclipse times. There is no
evidence of short period companions (P < 700 d) among this sample, but we do
find evidence for long term timing variations in 14 targets (34%). We argue
that this finding is consistent with the presence of tertiary companions among
a significant fraction of the targets, especially if many have orbits measured
in decades. This result supports the idea that the formation of close binaries
involves the deposition of angular momentum into the orbital motion of a third
star.Comment: AJ, in press, 104 pages, 2 figure sets plus 1 regular figur
Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).
Polychlorinated biphenyls (PCBs) are a family of persistent organic contaminants suspected to cause adverse effects in wildlife and humans. In rodents, PCBs bind to the aryl hydrocarbon (AhR) and pregnane X receptors (PXR) inducing the expression of catabolic cytochrome p450 enzymes of the CYP1A and 3A families. We found that certain highly chlorinated PCBs are potent activators of rodent PXR but antagonize its human ortholog, the steroid and xenobiotic receptor (SXR), inhibiting target gene induction. Thus, exposure to PCBs may blunt the human xenobiotic response, inhibiting the detoxification of steroids, bioactive dietary compounds, and xenobiotics normally mediated by SXR. The antagonistic PCBs are among the most stable and abundant in human tissues. These findings have important implications for understanding the biologic effects of PCB exposure and the use of animal models to predict the attendant risk
Modelling circumbinary protoplanetary disks I. Fluid simulations of the Kepler-16 and 34 systems
S.L and Z.M.L are supported by the STFC. P.J.C is grateful to NERC Grant NE/K004778/1. S.J.P. is supported by a Royal Society University Research Fellowship
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