170 research outputs found

    Circulating microRNAs as potential biomarkers of early vascular damage in vitamin D deficiency, obese, and diabetic patients

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    Vitamin D3 deficiency, obesity, and diabetes mellitus (DM) have been shown to increase the risk of cardiovascular diseases (CVDs). However, the early detection of vascular damage in those patients is still difficult to ascertain. MicroRNAs (miRNAs) are recognized to play a critical role in initiation and pathogenesis of vascular dysfunction. Herein, we aimed to identify circulating miRNA biomarkers of vascular dysfunction as early predictors of CVDs. We have recruited 23 middle-aged Emiratis patients with the following criteria: A healthy control group with vitamin D ≥ 20ng, and BMI 1.5) in high-risk patients for CVDs vs healthy controls. Collectively, our result indicates that four specific circulating miRNA signature, may be utilized as non-invasive, diagnostic and prognostic biomarkers for early vascular damage in patients suffering from vitamin D deficiency, obesity and DM

    Dynamical compressibility of dense granular shear flows

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    It has been conjectured by Bagnold [1] that an assembly of hard non-deformable spheres could behave as a compressible medium when slowly sheared, as the average density of such a system effectively depends on the confining pressure. Here we use discrete element simulations to show the existence of transverse and sagittal waves associated to this dynamical compressibility. For this purpose, we study the resonance of these waves in a linear Couette cell and compare the results with those predicted from a continuum local constitutive relation

    Optimal Byzantine Resilient Convergence in Asynchronous Robot Networks

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    We propose the first deterministic algorithm that tolerates up to ff byzantine faults in 3f+13f+1-sized networks and performs in the asynchronous CORDA model. Our solution matches the previously established lower bound for the semi-synchronous ATOM model on the number of tolerated Byzantine robots. Our algorithm works under bounded scheduling assumptions for oblivious robots moving in a uni-dimensional space

    Rendezvous on a Line by Location-Aware Robots Despite the Presence of Byzantine Faults

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    A set of mobile robots is placed at points of an infinite line. The robots are equipped with GPS devices and they may communicate their positions on the line to a central authority. The collection contains an unknown subset of "spies", i.e., byzantine robots, which are indistinguishable from the non-faulty ones. The set of the non-faulty robots need to rendezvous in the shortest possible time in order to perform some task, while the byzantine robots may try to delay their rendezvous for as long as possible. The problem facing a central authority is to determine trajectories for all robots so as to minimize the time until the non-faulty robots have rendezvoused. The trajectories must be determined without knowledge of which robots are faulty. Our goal is to minimize the competitive ratio between the time required to achieve the first rendezvous of the non-faulty robots and the time required for such a rendezvous to occur under the assumption that the faulty robots are known at the start. We provide a bounded competitive ratio algorithm, where the central authority is informed only of the set of initial robot positions, without knowing which ones or how many of them are faulty. When an upper bound on the number of byzantine robots is known to the central authority, we provide algorithms with better competitive ratios. In some instances we are able to show these algorithms are optimal

    Pattern formation

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    The Pattern Formation problem is one of the most important coordination problem for robotic systems. Initially the entities are in arbitrary positions; within finite time they must arrange themselves in the space so to form a pattern given in input. In this chapter, we will mainly deal with the problem in the OBLOT model

    Multisite campaign on the open cluster M67. III. Delta Scuti pulsations in the blue stragglers

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    We have made an asteroseismic analysis of the variable blue stragglers in the open cluster M67. The data set consists of photometric time series from eight sites using nine 0.6-2.1 meter telescopes with a time baseline of 43 days. In two stars, EW Cnc and EX Cnc, we detect the highest number of frequencies (41 and 26) detected in delta Scuti stars belonging to a stellar cluster, and EW Cnc has the second highest number of frequencies detected in any delta Scuti star. We have computed a grid of pulsation models that take the effects of rotation into account. The distribution of observed and theoretical frequencies show that in a wide frequency range a significant fraction of the radial and non-radial low-degree modes are excited to detectable amplitudes. Despite the large number of observed frequencies we cannot constrain the fundamental parameters of the stars. To make progress we need to identify the degrees of some of the modes either from multi-colour photometry or spectroscopy.Comment: 15 pages, 14 figs, one appendix. Part three in a series of papers describing results from an extensive multi-site campaign on the open cluster M6
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