A patológus szerepe a központi idegrendszer tumorainak diagnosztikájában, a terápiatervezésben. Prognosztikus és prediktív markerek vizsgálata

Despite advances in imaging methods, the standard of diagnosis and treatment of the tumours of the nervous system remains the histological report issued by a neuropathologist. For reliable, definitive diagnosis, close collaboration with other medical professions is essential, correlation of histological findings with clinical and imaging results is necessary. Neuropathology became a subspecialty because of the specific knowledge and experience it requires. In more complex cases consultation with neuropathologists is important to ensure adequate diagnosis and subsequent treatment. In both establishing the diagnosis and treatment planning, the molecular testing of brain tumors becomes more and more important. These tests are reliably available only in larger centers. Out of the molecular markers, in current practice the investigation of codeletion at 1p/19q, IDH mutations, beta-katenin nuclear positivity and MGMT methylation gained acceptance. Besides these tests already in practice, a vast array of potential diagnostic and prognostic markers are being investigated, which in the future may assist in delivering better and more individualized therapy

Research On Agricultural E-Government: Demands Possibilities and Players In Hungary

The Hungarian Government started a project for supporting research groups on e-government research. There are research groups from the University of Debrecen, the Szent István University and the Technical University of Budapest. We have made a joint proposal for researching agricultural e- government. The contract is signed and the research work has already started. Within this project we study the e emphasizing economical, professional and social aspects. The targets of the research are governmental, administrative tasks and demands, expectations and IT skill of citizens. -agricultural government systems, services, strategic demands and possibilities

New distribution data for two species of the Neotropical genus Lathecla Robbins, 2004 (Lepidoptera, Lycaenidae, Eumaeini)

Abstract. The species Lathecla carolyna Busby, 2015 described recently from Ecuador is reported to occur also in Venezuela and Colombia. An additional Peruvian occurrence of L. mimula (Draudt, 1920) is also documented

Élőhely-rekonstrukció lápi halfajok számára.

A Lápi póc Fajvédelmi Mintaprogram célja a nemzetközi jelentőségű lápi póc kárpát-medencei állományának megőrzése és gyarapítása. 2008-2010 között a Szadai Mintaterület (Pesti-síkság) degradált részein 6 db. kubikgödör méretű, egymástól elszigetelt vízteret hoztunk létre („Illés-tavak”). Az új vizekben és a lápi póc (Umbra krameri) természetes élőhelyein botanikai, vízkémiai, hidrobiológiai és halfaunisztikai vizsgálatokat végeztünk. A lápi póc egykori jelentős élőhelyein az amurgéb terjeszkedését figyeltük meg. 2009-ben saját szaporítású réti csíkot (Misgurnus fossilis) és széles kárászt (Carassius carassius) telepítettünk az 1. sz. Illés-tóba túlélési vizsgálat céljából. 2010-2011-ben 26 db. mentett póc anyahalat szaporítottunk, illetve 660 db. lárvát neveltünk fel. Az 1. sz. Illés-tó fizikai-kémiai vízminősége és a táplálékul szolgáló zooplankton és makrozoobenton faj- és egyedszáma két év alatt elérte a természetes „pócos” vizekre jellemző értékeket. A betelepített réti csíkok és széles kárászok jól fejlődtek, ezért 2010-2011 folyamán lápi póc anyahalakat és előnevelt pócokat telepítettünk az Illés-tavakba (génmegőrzés) és eredeti élőhelyükre. 2010-2011 tavaszán a széles kárász és a lápi póc sikeresen leívott az Illés-tavakban, a természetes póc szaporulat megközelítőleg 1000 db. lárva volt

Occupational Therapy Treatment to Improve Upper Extremity Function in Individuals with Early Systemic Sclerosis: A Pilot Study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146446/1/acr23522.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146446/2/acr23522_am.pd

Expression of VEGF in neonatal urinary obstruction: does expression of VEGF predict hydronephrosis?

BACKGROUND In animal studies, the inhibition of VEGF activity results in high mortality and impaired renal and glomerular development. Mechanical stimuli, like mechanical stretch in respiratory and circulatory systems, results in an elevated expression of VEGF. In animal models, the experimental urinary obstruction is associated with stretching of tubular cells and activations of the renin-angiotensin system. This results in the upregulation of vascular endothelial growth factor (VEGF) and TNF-alfa. MATERIAL AND METHODS Tissue samples from urinary tract obstruction were collected and immunohistochemistry was performed in 14 patients (average age: 7.1+/-4.1 years). The control histology group consisted of ureteropelvic junction tissue from 10 fetuses after midtrimester artificial abortion. The fetuses did not have any failure at ultrasound screening and pathological examination. The mean gestational age was 20.6 weeks of gestation (+/-2.2SD). Expression of VEGF was detected with immunohistochemistry method. RESULTS Expression of VEGF was found in varying intensity in the submucosa and subserosa layers, but only in the test tissue (placental tissue). The tissue of the patients with urinary obstruction and the tissue of the fetal ureteropelvic junction without urinary obstruction were negative for expression of VEGF. The repeated examination showed negative cells and no color staining. CONCLUSIONS The pressure due to congenital urogenital obstruction resulting in mechanical stress in cells did not increase the expression of VEGF in young children in our study. To find a correlation between urogenital tract obstruction and increased expression of VEGF, we need to perform more examinations because the connection may be of therapeutic significance

Inflammation and oxidative stress caused by nitric oxide synthase uncoupling might lead to left ventricular diastolic and systolic dysfunction in patients with hypertension

Objective: To investigate the role of oxidative stress, inflammation, hypercoagulability and neuroendocrine activation in the transition of hypertensive heart disease to heart failure with preserved ejection fraction (HFPEF). Methods: We performed echocardiography for 112 patients (≥ 60 years old) with normal EF (18 controls and 94 with hypertension), and determined protein carbonylation (PC), and tetrahydrobiopterin (BH4), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), fibrinogen, plasminogen activator inhibitor type-I (PAI-I), von Willebrand factor, chromogranin A (cGA) and B-type natriuretic peptide (BNP) levels from their blood samples. Results: We found that 40% (38/94) of the patients with hypertension (HT) had no diastolic dysfunction (HTDD-), and 60% (56/94) had diastolic dysfunction (HTDD+). Compared to the controls, both patient groups had increased PC and BH4, TNF-α, PAI-I and BNP levels, while the HTDD+ group had elevated cGA and CRP levels. Decreased atrial and longitudinal left ventricular (LV) systolic and diastolic myocardial deformation (strain and strain rate) was demonstrated in both patient groups versus the control. Patients whose LV diastolic function deteriorated during the follow-up had elevated PC and IL-6 level compared to their own baseline values, and to the respective values of patients whose LV diastolic function remained unchanged. Oxidative stress, inflammation, BNP and PAI-I levels inversely correlated with LV systolic, diastolic and atrial function. Conclusions: In patients with HT and normal EF, the most common HFPEF precursor condition, oxidative stress and inflammation may be responsible for LV systolic, diastolic and atrial dysfunction, which are important determinants of the transition of HT to HFPEF

Zeros of the i.i.d. Gaussian power series: a conformally invariant determinantal process

Consider the zero set of the random power series f(z)=sum a_n z^n with i.i.d. complex Gaussian coefficients a_n. We show that these zeros form a determinantal process: more precisely, their joint intensity can be written as a minor of the Bergman kernel. We show that the number of zeros of f in a disk of radius r about the origin has the same distribution as the sum of independent {0,1}-valued random variables X_k, where P(X_k=1)=r^{2k}. Moreover, the set of absolute values of the zeros of f has the same distribution as the set {U_k^{1/2k}} where the U_k are i.i.d. random variables uniform in [0,1]. The repulsion between zeros can be studied via a dynamic version where the coefficients perform Brownian motion; we show that this dynamics is conformally invariant.Comment: 37 pages, 2 figures, updated proof