Consequences of AphanizomenonFlos-aquae(AFA) extract (StemtechTM) on metabolic profile of patients with type 2 diabetes

Background: Blue- green algae is one of the most nutrient dense foods which is rich in substances that have useful effects on human health. The purpose of this study was to evaluate the effectiveness of a water- soluble extract of the cyanophyta Aphanizomenon Flos-aquae (StemtechTM) as a functional supplement on CD markers, lipid profile, glucose levels as well as its side effects in Iranian patients with type 2 diabetes. Methods: During this randomized, double-blind, placebo-controlled trial 49 type 2 diabetic patients, aged between 20 and 60years with a HbA1C�7.5, were allocated. Patients were divided into two groups of placebo and treated with an equal ratio 1:1. The subjects in StemtechTM group received one capsule of StemFlo (508mg) before breakfast and two capsules of StemEnhance (500mg) after each meal for a period of 12weeks, and placebo group was instructed to take placebo with the same pattern. During the intervention period, subjects were asked to keep usual diet and prohibited to take any functional foods or dietary supplements. Metabolic panel has been measured as the primary outcome of study at the beginning and end of the intervention period via blood sampling. Results: StemtechTM supplementation for 12weeks decreased fasting blood glucose (FBG) and Glycatedhemoglobin (HbA1c). Mean serum chemistry parameters (Triglyceride, Total Cholesterol, LDL, HDL, CRP, AST, ALT, BUN and Creatinine) as well as CD 34+, IL-6, TNF-aα in treated and control groups before and after the study showed no considerable dissimilarities. Conclusion: StemtechTM intervention brought in positive consequence on blood glucose levels in Iranian patients with type 2 diabetes, consequently suggests the StemtechTM as a functional food for the management of diabetes. © 2015 Sanaei et al

Vestibular-balance rehabilitation in patients with whiplash-associated disorders

Background and objective: Whiplash associated syndrome is one of the neck disorders that is accompanied by several chronic symptoms. Balancing problems arising from common disorders and dizziness are considered as manifestations that are time-consuming to evaluate and treat. The present study aims to investigate the effect of vestibular-balance rehabilitation using a test that can be used for differential diagnosis of these lesions by comparing dizziness handicap inventory (DHI) and Smooth Pursuit Neck Torsion (SPNT) scores. Method: This was an analytical cross-sectional study with a two-stage design. Forty patients with whiplash-associated disorders were randomly divided into control and intervention groups. SPNT test and DHI evaluation were performed for both groups. For twenty people selected randomly in the intervention group, vestibular-balance rehabilitation was performed during 12 sessions. Finally, the SPNT and DHI tests were performed again to examine and compare the results. Results: The results of this study showed that there was a statistically significant difference between the scores of smooth pursuit neck torsion gain in the SPNT test, the total score of DHI, the functional components of this questionnaire between the control and intervention groups after the implementation of the rehabilitation, and the differences in the physical, functional, and emotional components of the questionnaires of the control and intervention groups after rehabilitation exercises. Conclusion: Vestibular-balance rehabilitation exercises can be an effective treatment for dizziness and improving the quality of life of a person suffering from whiplash-associated disorder, followed by the reduction in dizziness caused by disability. © 2019 International Tinnitus Journal. All rights reserved

Understanding Hydrogen Adsorption in MIL-47-M (M = V and Fe) through Density Functional Theory

The present paper aims to investigate the role of open metal site metal-organic frameworks (MOFs) on hydrogen adsorptivity using periodic boundary condition (PBC) density functional theory (DFT). Hence, MIL-47-M (M = V and Fe) were selected and one hydrogen molecule adsorptivity was calculated in different orientations on them. Four different chemical sites were identified in every cluster section of these MOFs, and molecular hydrogen adsorption was studied in these sites. In these MOFs, V has fewer electrons than Fe in its valence layer. Results demonstrated that when dihedral angle of M-O-H-H is 0, the binding energy of hydrogen adsorption is higher than that in other orientations in both MILs (-26.16 and -19

Association between dietary intake and seasonal variations in postmenopausal women

Background: Evidence supports that increasing number of postmenopausal women are suffering from one or more chronic diseases. Dietary patterns have a pivotal role in maintaining human health. The aim of this study was to characterize the nutrients and energy intake in postmenopausal women, with the special focus on seasonal variation effect in their food intake.Methods: The study population consisted of 30 postmenopausal women referred to Dr. Shariati Hospital, Tehran (Iran). Socio-demographic characteristics and BMI were registered. Dietary assessment was performed by a 3 day food records in each season through one year, allowing the estimation of energy, protein, carbohydrate, total fat, monounsaturated fatty acid (MUFA), polyunsaturated fatty acids (PUFA) and saturated fatty acids (SFA) intake. The mean of nutrient intake in each season was adjusted for energy intake. The effect of season on energy and nutrients intake was assessed based on the General linear model (GLM).Results: The mean of daily intake of vitamin C, B, B2, B12, iron, zinc, phosphorus and chromium was significantly higher than Recommended Dietary Allowance (RDAs ) (p < 0.05). The mean of vitamin D, E, B6, B5, folate, calcium, magnesium, potassium and selenium consumption was significantly less than RDAs (p < 0.05). All the participants meet the goal for vitamins A, K and B3 from food. The mean of energy intake was not different between seasons. However, the mean intake of fat, vitamin C, vitamin K and folate was significantly different between seasons.Conclusion: These findings highlight some nutrients deficiency in postmenopausal women and therefore suggest nutritional education with emphasis on seasonal variation effect. © 2014 Mansour et al.; licensee BioMed Central Ltd

Association between dietary intake and seasonal variations in postmenopausal women

Background: Evidence supports that increasing number of postmenopausal women are suffering from one or more chronic diseases. Dietary patterns have a pivotal role in maintaining human health. The aim of this study was to characterize the nutrients and energy intake in postmenopausal women, with the special focus on seasonal variation effect in their food intake.Methods: The study population consisted of 30 postmenopausal women referred to Dr. Shariati Hospital, Tehran (Iran). Socio-demographic characteristics and BMI were registered. Dietary assessment was performed by a 3 day food records in each season through one year, allowing the estimation of energy, protein, carbohydrate, total fat, monounsaturated fatty acid (MUFA), polyunsaturated fatty acids (PUFA) and saturated fatty acids (SFA) intake. The mean of nutrient intake in each season was adjusted for energy intake. The effect of season on energy and nutrients intake was assessed based on the General linear model (GLM).Results: The mean of daily intake of vitamin C, B, B2, B12, iron, zinc, phosphorus and chromium was significantly higher than Recommended Dietary Allowance (RDAs ) (p < 0.05). The mean of vitamin D, E, B6, B5, folate, calcium, magnesium, potassium and selenium consumption was significantly less than RDAs (p < 0.05). All the participants meet the goal for vitamins A, K and B3 from food. The mean of energy intake was not different between seasons. However, the mean intake of fat, vitamin C, vitamin K and folate was significantly different between seasons.Conclusion: These findings highlight some nutrients deficiency in postmenopausal women and therefore suggest nutritional education with emphasis on seasonal variation effect. © 2014 Mansour et al.; licensee BioMed Central Ltd

Association of dietary patterns with continuous metabolic syndrome in children and adolescents; A nationwide propensity score-matched analysis: The CASPIAN-V study

Objective: This study aims to determine the association of dietary patterns with metabolic syndrome (MetS) and its components in children and adolescents. Methods: This nationwide study was conducted in 2015 among 4200 students aged 7-18 years, who lived in 30 provinces in Iran. The analysis was conducted based on the propensity score using a matched case-control study design. Three dietary patterns were obtained conducting a principal component analysis with a varimax rotation on 16 dietary groups. Continuous MetS score was computed by standardizing the residuals (z-scores) of MetS components by regressing them according to age and sex. The gold standard diagnosis of MetS was considered based on the International Diabetes Federation criteria. Moreover, for the purpose of data analysis, matched logistics analysis was used. Results: The study participants consisted of 3843 children and adolescents (response rate 91.5) with mean (SD) age of 12.45 (3.04) years. Totally 49.4 of students were girls and 71.4 lived in urban areas. Three dietary patterns were obtained: Healthy, Western, and Sweet. Prevalence of MetS was 5 (boy 5.5 and girl 4.5). Results of multivariate analysis show that students with Sweet dietary patterns were at higher risk for abdominal obesity (OR 1.29; 95 CI 1.01-1.66), elevated blood pressure (OR 1.35; 95 CI 1.01-1.81) and MetS (OR 1.33; 95 CI 1.02-1.74). The two other dietary patterns were not associated with MetS and its components. Conclusion: Sweet dietary pattern increase the risk of MetS and some its components in Iranian children and adolescents. This finding provides valuable information for effective preventive strategies of MetS based on diet rather than medication to maintain healthy lifestyle habits. © 2018 The Author(s)

Prediction of leak flow rate in plastic water distribution pipes using vibro-acoustic measurements

Leakage from water distribution systems is a worldwide issue with consequences including loss of revenue, health and environmental concerns. Leaks have typically been found through leak noise correlation by placing sensors either side of the leak and recording and analysing its vibro-acoustic emission. While this method is widely used to identify the location of the leak, the sensors also record data that could be related to the leak’s flow rate, yet no reliable method exists to predict leak flow rate in water distribution pipes using vibro-acoustic emission. The aim of this research is to predict leak flow rate in medium-density polyethylene pipe using vibro-acoustic emission signals. A novel experimental methodology is presented whereby circular holes of four sizes are tested at several leak flow rates. Following the derivation of a number of features, least squares support vector machines are used in order to predict leak flow rate. The results show a strong correlation highlighting the potential of this technique as a rapid and practical tool for water companies to assess and prioritise leak repair

A pH‐Triggered Polymer Degradation or Drug Delivery System by Light‐Mediated Cis / Trans Isomerization of o ‐Hydroxy Cinnamates

A new methodology for the pH-triggered degradation of polymers or for the release of drugs under visible light irradiation based on the cyclization of ortho-hydroxy-cinnamates (oHC) to coumarins is described. The key oHC structural motif can be readily incorporated into the rational design of novel photocleavable polymers via click chemistry. This main-chain moiety undergoes a fast photocleavage when irradiated with 455 nm light provided that a suitable base is added. A series of polyethylene glycol-alt-ortho-hydroxy cinnamate (polyethylene glycol (PEG)n-alt-oHC)-based polymers are synthesized and the time-dependent visible-light initiated cleavage of the photoactive monomer and polymer is investigated in solution by a variety of spectroscopic and chromatographic techniques. The photo-degradation behavior of the water-soluble poly(PEG2000-alt-oHC) is investigated within a broad pH range (pH = 2.1–11.8), demonstrating fast degradation at pH 11.8, while the stability of the polymer is greatly enhanced at pH 2.1. Moreover, the neat polymer shows long-term stability under daylight conditions, thus allowing its storage without special precautions. In addition, two water-soluble PEG-based drug-carrier molecules (mPEG2000-oHC-benzhydrol/phenol) are synthesized and used for drug delivery studies, monitoring the process by UV–vis spectroscopy in an ON/OFF intermittent manner

RNA delivery by extracellular vesicles in mammalian cells and its applications.

The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of cellular origin that derive either from the endosomal compartment (exosomes) or as a result of shedding from the plasma membrane (microvesicles, oncosomes and apoptotic bodies). Extracellular vesicles carry a variety of cargo, including RNAs, proteins, lipids and DNA, which can be taken up by other cells, both in the direct vicinity of the source cell and at distant sites in the body via biofluids, and elicit a variety of phenotypic responses. Owing to their unique biology and roles in cell-cell communication, extracellular vesicles have attracted strong interest, which is further enhanced by their potential clinical utility. Because extracellular vesicles derive their cargo from the contents of the cells that produce them, they are attractive sources of biomarkers for a variety of diseases. Furthermore, studies demonstrating phenotypic effects of specific extracellular vesicle-associated cargo on target cells have stoked interest in extracellular vesicles as therapeutic vehicles. There is particularly strong evidence that the RNA cargo of extracellular vesicles can alter recipient cell gene expression and function. During the past decade, extracellular vesicles and their RNA cargo have become better defined, but many aspects of extracellular vesicle biology remain to be elucidated. These include selective cargo loading resulting in substantial differences between the composition of extracellular vesicles and source cells; heterogeneity in extracellular vesicle size and composition; and undefined mechanisms for the uptake of extracellular vesicles into recipient cells and the fates of their cargo. Further progress in unravelling the basic mechanisms of extracellular vesicle biogenesis, transport, and cargo delivery and function is needed for successful clinical implementation. This Review focuses on the current state of knowledge pertaining to packaging, transport and function of RNAs in extracellular vesicles and outlines the progress made thus far towards their clinical applications

Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P &lt;.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes