Understanding tissue morphology: model repurposing using the CoSMoS process

We present CoSMoS as a way of structuring thinking on how to reuse parts of an existing model and simulation in a new model and its implementation. CoSMoS provides a lens through which to consider, post-implementation, the assumptions made during the design and implementation of a software simulation of physical interactions in the formation of vascular structures from endothelial cells. We show how the abstract physical model and its software implementation can be adapted for a different problem: the growth of cancer cells under varying environmental perturbations. We identify the changes that must be made to adapt the model to its new context, along with the gaps in our knowledge of the domain that must be filled by wet-lab experimentation when recalibrating the model. Through parameter exploration, we identify the parameters that are critical to the dynamic physical structure of the modelled tissue, and we calibrate these parameters using a series of in vitro experiments. Drawing inspiration from the CoSMoS project structure, we maintain confidence in the repurposed model, and achieve a satisfactory degree of model reuse within our in silico experimental system

Assessment of nausea and vomiting of pregnancy on antenatal clients of Addis Ababa

Background: Nausea and vomiting of pregnancy (NVP) are common symptoms experienced during pregnancy. Both mild and severe symptoms can have significant morbidities and socioeconomic impact. Despite its frequency and associated distress, its exact cause is unknown. No study was done addressing this particular important issue in our country and this study will serve as a bench mark for future work on the topic in the Ethiopian context.Objective: To assess nausea and vomiting of pregnancy on ANC (antenatal care) clients of three hospitals of Addis Ababa.Methods: A descriptive facility based cross-sectional study, done in three teaching hospitals of Addis Ababa, the capital city of Ethiopia. Semi-structured questionnaires were administered to random sample of 384 pregnant women. Descriptive statistic was used to summarize data. P-value and χ² test were used to measure associations.Results: The prevalence of nausea and vomiting of pregnancy was 74.5%, with 4.4% being admitted for severe symptoms. It was found out that 91% had symptoms in the 1st trimester, 2.1% after mid pregnancy, and 85% were triggered by smell and taste. Primigravidity, nulliparity, excessive salivation and food aversion were significantly associated with nausea and vomiting connected with pregnancy. Significant associations were also observed between admission for severity and being unmarried, loss to work, affected relationship, more frequent vomiting, and early onset of symptoms. Severe frequency of vomiting was a major factor associated with admission for severity and loss to work.Conclusion and recommendation: Nausea and vomiting of pregnancy found in this study were similar to other studies. Sensory stimuli were major trigger of symptoms and more frequent vomiting was linked with more admission. Importance of supportive measures, rest, counseling and advice on diet and life style modification needs to be underscored and early treatment of vomiting need to be considered

Deer Frozen Semen Quality in Tris Sucrose and Tris Glucose Extender with Different Glycerol Concentrations

In order to improve Timor deer (Cervus timorensis) frozen semen quality, the influence of sugar and glycerol concentration on semen characteristics of sperm was investigated. The semen was collected from five sexually mature Timor deer using an electroejaculator. The semen was evaluated and divided into six equal tubes and diluted with Tris sucrose glycerol 10% (TSG10); Tris sucrose glycerol 12% (TSG12); Tris sucrose glycerol 14% (TSG14); Tris glucose glycerol 10% (TGG10); Tris glucose glycerol 12% (TGG12); and Tris glucose glycerol 14% (TGG14). The diluted semen was packed in 0.3 ml minitub straw, equilibrated at 5 oC for 4 hours and frozen on liquid nitrogen vapor for 10 minutes. The total of forward motility, viability, acrosome integrity and membrane integrity were assessed in fresh, after equilibration and after thawing. Results demonstrated that the percentage of sperm motility in TSG10was higher (P (63.93±7.23%). The sperm in TSG10 and TSG14 extender were superior in acrosome as well as in membrane integrity. It was concluded that Tris Sucrose with 10% glycerol protected Timor deer sperm better than other combinations

Penerapan Model Pembelajaran Generatif (Mpg) Untuk Pelajaran Matematika Di Kelas X SMA Negeri 8 Palembang

Penelitian terapan ini bertujuan untuk mengetahui keefektifan penerapan MPG untuk pelajaran matematika di kelas X SMA Negeri 8 Palembang, di tinjau dari ketuntasan belajar yang dicapai setelah mengikuti pembelajaran dengan menggunakan MPG, keaktifan siswa selama di terapkan MPG, sikap terhadap penerapan MPG. Penelitian ini merupakan penelitian terapan (applied research) dengan menggunakan metode eksperimen dan survey. Pengumpulan data dengan observasi, tes, angket serta wawancara . Data yang dikumpulkan dianalisis secara deskriptif kuantitatif dan kualitatif, dengan menggunakan teknik analisa data statistik persentase skor serta tabel keefektifan penerapan model. Dari hasil penelitian disimpulkan bahwa keefektifan penerapan MPG untuk pelajaran matematika dikelas X SMA Negeri 8 Palembang yang ditinjau dari aktivitas siswa, ketuntasan belajar serta sikap siswa terhadap penerapan MPG adalah 76.32 % dengan kategori ”Efektif” , dengan rincian keaktifan siswa selama diterapkan MPG tergolong sangat tinggi dengan rata-rata persentase skor 81.8% dan ketuntasan belajar siswa secara klasikal mencapai 76.32%, serta Sikap siswa terhadap penerapan MPG tergolong positif dengan rata-rata persentase skor 76.5%

Makanan Hantaran pada Upacara Perkawinan di Desa Sungai Abu Kecamatan Hiliran Gumanti Kabupaten Solok Provinsi Sumatera Barat

The background of this research is the lack knowledge of sungai Abu citizen about the a series of delivery events, which brought indigenous food, the tools used to carry food customs and customary meaning of food brought to the delivery and implementation of events that play a role in treating food only mothers aged 60 years. The purposes of this study are (1) to describe the implementation of a series of ceremonial delivery, (2) describe the type of custom foods delivery, (3) describe the equipment used to carry the customary food delivery (4) expresses the meaning of food delivery at the ceremony. The research is a qualitative research, the research object is the customary food that is brought in delivery event in the village of sungai Abu. The instrument used in this study is the observation, interview and documentation. Data are analyzed using data reduction, data presentation, drawing conclusions and verification. The results showed that the delivery event in Sungai abu village be held in the second day of marriage ceremony, conducting a series of delivery events in the village of sungai abu has two stages: preparation before the event and conducting a series of traditional ceremonies, the type of food served at the delivery ceremony are 23 species and which as a symbol of niniak mamak and interest to both families

Analysis of Youth Interest in Work as Sheep Farmers at P4S LKP2U

An increase in the number of demands for lamb meat every year represents livestock business opportunity while the supply from smallholder farmers continues to decline, causing prices to rise yearly. Sustainability is important in the sheep farming business, which older farmer dominated. The objective of this research was to assess the inclination of the younger population towards pursuing careers as sheep farmers after participating at the Pusat Pelatihan Pertanian Pedesaan Swadaya (P4S) of Lembaga Kajian dan Pengembangan Potensi Umat (LKP2U) program in the Madiun Regency. Novelty of the research is the presentation of the latest information on youth interest in working as a farmer. Data collection was carried out in December 2022 using non-probability sampling. The data in this study were analyzed using a Likert scale to measure entrepreneurial interest and demographic factors. Furthermore, a binary logistic regression analysis was conducted to determine the relationship between the predictor and response variables. Youth interest after participating in the training program chooses an interest in working as a sheep farmer at 70%. Factors that influence youth interest after attending the training program towards employment as a sheep farmer are demographic factors namely age, marital status, duration of education, parents occupation, parents income, family members, and entrepreneurial factors (e.g personal, environmental, and social)

The Quality of Stallion Semen in Skim Milk and Dimitropoulos Extenders Preserved at 5 oC and Ambient Temperature Supplemented with Different Sugar

This study was conducted to evaluate the effects of sugars supplementation in skim milk based (SM) and dimitropoulos (DV) extenders on the sperm motility and viability in stallion semen storage at 5 oC and ambient temperature (24-29 oC). Semen samples were collected from 3 stallions; evaluate individually and each of them divided into 8 aliquots. Four out of eight aliquots were diluted 1:1 with SM, while the remaining four were diluted 1:1 with DV; all were then centrifuged at 1006 g (3000 RPM) for 15 min. The supernatants were discarded, and each pellet was re-diluted with SM (control), SM trehalose (SMT), SM-raffinose (SMR), SM-fructose (SMF), DV (control), DV-trehalose (DVT), DV-raffinose (DVR), and DV-fructose (DVF). The diluted semen were divided into 2 aliquots and stored at 5 oC or ambient temperature. The sperm motility and viability were evaluated every 3 h on chilled semen stored at ambient temperature, and every 12 h on those stored at 5 oC. Results of the experiments demonstrated that sperm motility and viability in DV extender significantly higher (P < 0.05) in both temperature. The supplementation of fructose was the best on the motility and viability of the sperm at both temperatures compare to trehalose, raffinose, or the control group. The best extender and sugar combination was DVF, which the total motile sperm stored at 5 oC for 96 h was 45.1% followed by to DVT (40.2%) and DVR (39.2%). The sperm motility in DV and SMF were 35.3% and 35.6%, respectively; these were higher than those diluted with control (28.9%); SMT (30.3%), and SMR (29.6%). The study concluded that the supplementation of fructose in DV extender (DVF) was the best combination to preserve stallion sperm motility and viability stored at 5 oC or ambient temperature

The Distribution of Favites Abdita Coral Reef (Ellis and Solander, 1786) in the Land of Coral Coast Village of Malalayang Dua, Malalayang Sub-district Manado

This study was conducted at Malalayang Dua waters (Sub-district Malalayang Dua, Manado City). The aim of study is: To know and to inform the coral of Favites abdita. The other aim was to describe the distribution of Favites abdita. This research also will contribute for the management effort of coral reef in Malalayang Dua area, and also as information and literature in doing research at the same place in the future. Data collection was done by using simple random method with 1x1 meter quadrant. Every coral found was wrote at data sheet. The pictures of those coral was taken by using underwater camera. The highest percentage cover of hard coral was found in station 3 (1.46%), while the lowest was wrote at station first (0.13%). The distributions patterns of hard coral were found in each stations are Clumped. There is no significant difference in number of colony, percentage cover and diameter for the three depths