Cell transcriptomic atlas of the non-human primate Macaca fascicularis.

Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.We thank W. Liu and L. Xu from the Huazhen Laboratory Animal Breeding Centre for helping in the collection of monkey tissues, D. Zhu and H. Li from the Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) for technical help, G. Guo and H. Sun from Zhejiang University for providing HCL and MCA gene expression data matrices, G. Dong and C. Liu from BGI Research, and X. Zhang, P. Li and C. Qi from the Guangzhou Institutes of Biomedicine and Health for experimental advice or providing reagents. This work was supported by the Shenzhen Basic Research Project for Excellent Young Scholars (RCYX20200714114644191), Shenzhen Key Laboratory of Single-Cell Omics (ZDSYS20190902093613831), Shenzhen Bay Laboratory (SZBL2019062801012) and Guangdong Provincial Key Laboratory of Genome Read and Write (2017B030301011). In addition, L.L. was supported by the National Natural Science Foundation of China (31900466), Y. Hou was supported by the Natural Science Foundation of Guangdong Province (2018A030313379) and M.A.E. was supported by a Changbai Mountain Scholar award (419020201252), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030502), a Chinese Academy of Sciences–Japan Society for the Promotion of Science joint research project (GJHZ2093), the National Natural Science Foundation of China (92068106, U20A2015) and the Guangdong Basic and Applied Basic Research Foundation (2021B1515120075). M.L. was supported by the National Key Research and Development Program of China (2021YFC2600200).S

Cucullitingis Du & Yao 2018, gen. nov.

Genus Cucullitingis gen. nov. Type species. Cucullitingis biacantha sp. nov. (Fig. 1) General description. Macropterous. Head slightly produced in front of the compound eyes, with four spines, two dorsomedial and two frontals, bucculae extended half-length of head. Antenna four-segmented, length of third segment the longest. Pronotum short, without posterior projection; Apex of the paranota forming a spine. Scutellum reduced but visible; collar three areolae wide, forming a spheroid hood, cover up the posterior of head. Hemelytra areolate, subcostal area narrower and higher than costal area and discoidal area; no stenocostal area. Legs long and slender, tarsi two-segmented. Etymology. The generic name is a combinated a Latin word “ cucull- ” (meaning hood) and the stem name of family Tingidae. The gender is feminine.Published as part of Du, Sile & Yao, Yunzhi, 2018, A new genus and species of Tingidae (Heteroptera: Cimicomorpha) from Myanmar, with the analysis of the evolution of hood, carinae and paranota, pp. 283-293 in Zoological Systematics 43 (3) on page 284, DOI: 10.11865/zs.201828, http://zenodo.org/record/536050

New Cretaceous Bugs from Northeastern China Imply the Systematic Position of Pachymeridiidae (Hemiptera: Heteroptera)

Varicapitatus sinuolatus gen. et sp. nov. is described from the Yixian Formation of Northeastern China. Based on the new specimens, this study discusses the morphological characteristics and taxonomic position of Pachymeridiidae: Pachymeridiidae belongs to Pentatomomorpha and is more closely related to Lygaeoidea. In Heteroptera, the costal fracture of the forewing is a homoplastic characteristic, already evolved independently several times among most taxa before the Early Cretaceous. The pulvillus under the claw in Pentatomomorpha is also a homoplastic characteristic. In Pachymeridiidae, the forewing costal fracture and absence of pulvillus can be recognized as an independent evolution or convergence, implying that pachymeridiids may have different flight and crawling behaviors distinct from other Pentatomomorpha groups

A new genus and species of burrower bugs (Heteroptera: Cydnidae) from the mid-Cretaceous Burmese amber

Wang, Yijia, Du, Sile, Yao, Yunzhi, Ren, Dong (2019): A new genus and species of burrower bugs (Heteroptera: Cydnidae) from the mid-Cretaceous Burmese amber. Zootaxa 4585 (2): 351-359, DOI: https://doi.org/10.11646/zootaxa.4585.2.

Punctacorona Wang, Du, Yao & Ren 2019, gen. nov.

Genus Punctacorona Wang, Du, Yao & Ren gen. nov. urn:lsid:zoobank.org:act: F9969495-7B8E-4551-9177-6DE01E17DFCC Type species. Punctacorona triplosticha sp. nov. Diagnosis. Clypeus longer than paraclypei, with 4 peg-like setae marginally, paraclypei with 6 peg-like setae marginally, all marginal setigerous punctures arising from its own well-developed tubercle; ocelli present (Fig. 2A, B). Pronotum trapezoidal, almost parallel-sided, anterior angles expanded, coxal combs scale-like. Scutellum triangular, about 2 times longer than claval commissure. Clavus with 3 rows of coarse punctures (Fig. 3); claval commissure present; evaporatorium on metapleuron extensive, covering most of segment, very large, with mycoid micro sculpture (Fig. 4 D, I), metapleuron neighboring to posterior margin of evaporatorium carinate (Fig. 2B; Fig. 4D); R+M separated from C+Sc at 1/5 of corium, anterior margin of forewing angulated. Etymology. The generic name is a combination of the Latin Punct - (“Little dot”) and corona (referring its clypeus longer than paraclypei, with peg-like setae), gender feminine. Distribution. Myanmar.Published as part of Wang, Yijia, Du, Sile, Yao, Yunzhi & Ren, Dong, 2019, A new genus and species of burrower bugs (Heteroptera: Cydnidae) from the mid-Cretaceous Burmese amber, pp. 351-359 in Zootaxa 4585 (2) on page 353, DOI: 10.11646/zootaxa.4585.2.8, http://zenodo.org/record/263739

TamForen: A tamper-proof cloud forensic framework

Cloud forensics has become increasingly critical in cloud computing security in recent years. A fundamental problem in cloud forensics is how to safely and effectively obtain, preserve, and analyze evidence. With massive cloud forensic systems and tools having been proposed over the years, we identify one challenge that is not adequately addressed in the current literature. The problem is “credibility of cloud evidence”; this is where the evidence collected in the cloud is unreliable due to its multitenancy and the multiple participants in the forensic process. In this paper, we develop a new Cloud Forensics Tamper-Proof Framework (TamForen) for cloud forensics, which can be used in an untrusted and multitenancy cloud environment. This framework relies on the cloud forensics system independent of the daily cloud activities and is implemented based on the Multilayer Compressed Counting Bloom Filter. Unlike existing cloud forensics methods that depend on the support and trust of cloud service providers, TamForen takes into account the untrustworthiness of participants in the forensics process and conducts tamper-proof protection of data in a decentralized way without violating users' privacy. We simulate a cloud forensics environment to evaluate TamForen, and the results show that TamForen is feasible

Dehiscensicoridae fam. nov. (Insecta: Heteroptera: Pentatomomorpha) from the Upper Mesozoic of Northeast China

<p>A new family of insects is described from the Lower Cretaceous Yixian Formation in western Liaoning Province, China. Dehiscensicoridae Du, Yao & Ren fam. nov. comprises five new genera and five new species: <i>Dehiscensicoris sanctus</i> Du, Yao & Ren gen. et sp. nov., <i>Pingquanicoris punctatus</i> Du, Yao & Ren gen. et sp. nov., <i>Changirostrus maculatus</i> Du, Yao & Ren gen. et sp. nov., <i>Crassiantenninus minutus</i> Du, Yao & Ren gen. et sp. nov. and <i>Minuticoris brunneus</i> Du, Yao & Ren gen. et sp. nov. A cladistic analysis based on a combination of fossil and extant morphological characters is used to hypothesize the phylogenetic status of the new family, allowing the reconstruction of the interfamily relationships within the Coreoidea (<i>sensu lato</i>) which were found to be: Pyrrhocoroidea + (Dehiscensicoridae fam. nov. + (Coreoidea + (Idiostoloidea + Lygaeoidea))).</p> <p><a href="http://zoobank.org/urn:lsid:zoobank.org:pub:" target="_blank">http://zoobank.org/urn:lsid:zoobank.org:pub:</a>E501B670-AF36-408C-8B9D-466B330BA775</p

T-SPOT with CT image analysis based on deep learning for early differential diagnosis of nontuberculous mycobacteria pulmonary disease and pulmonary tuberculosis

Objectives: This study aimed to establish a diagnostic algorithm combining T-SPOT with computed tomography image analysis based on deep learning (DL) for early differential diagnosis of nontuberculous mycobacteria pulmonary disease (NTM-PD) and pulmonary tuberculosis (PTB). Methods: A total of 1049 cases were enrolled, including 467 NTM-PD and 582 PTB cases. A total of 320 cases (160 NTM-PD and 160 PTB) were randomized as the testing set and were analyzed using T-SPOT combined with the DL model. The testing cases were first divided into T-SPOT-positive and -negative groups, and the DL model was then used to separate the cases into four subgroups further. Results: The precision was found to be 91.7% for the subgroup of T-SPOT-negative and DL classified as NTM-PD, and 89.8% for T-SPOT-positive and DL classified as PTB, which covered 66.9% of the total cases, compared with the accuracy rate of 80.3% of T-SPOT alone. In the other two remaining groups, where the T-SPOT prediction was inconsistent with the DL model, the accuracy was 73.0% and 52.2%, separately. Conclusion: Our study shows that the new diagnostic system combining T-SPOT with DL based computed tomography image analysis can greatly improve the classification precision of NTM-PD and PTB when the two methods of prediction are consistent

Rapid Prediction of the Open-Circuit-Voltage of Lithium Ion Batteries Based on an Effective Voltage Relaxation Model

The open circuit voltage of lithium ion batteries in equilibrium state, as a vital thermodynamic characteristic parameter, is extensively studied for battery state estimation and management. However, the time-consuming relaxation process, usually for several hours or more, seriously hinders the widespread application of open circuit voltage. In this paper, a novel voltage relaxation model is proposed to predict the final open circuit voltage when the lithium ion batteries are in equilibrium state with a small amount of sample data in the first few minutes, based on the concentration polarization theory. The Nernst equation is introduced to describe the evolution of relaxation voltage. The accuracy and effectiveness of the model are verified using experimental data on lithium ion batteries with different kinds of electrodes (LiCoO2/mesocarbon-microbead and LiFePO4/graphite) under different working conditions. The validation results show that the presented model can fit the experimental results very well and the predicted values are quite accurate by taking only 5 min or less. The satisfying results suggest that the introduction of concentration polarization theory might provide researchers an alternative model form to establish voltage relaxation models