188 research outputs found
Comparative Study on the Spatial Layout of Buddhist and Taoist Temples in Chengdu
Buddhism and Taoism have enjoyed a flourishing development in Chengdu with many famous Buddhist and Taoist temples. This research takes typical Buddhist temple buildings and Taoist temple buildings in Chengdu as the research object. Through architectural surveying and mapping, the height and area data of temple buildings are quantized and counted, and their components and axial spatial plane and vertical layout characteristics are analyzed and compared. The results show that both Buddhist temples and Taoist temples are composed of two elements, including figure worship and non-figure worship. In the plane layout, they are mostly used in the south and straight line layout. The hierarchy of the halls in Buddhist temples is clear, while Taoist temples are more open. By clarifying their respective characteristics, the study achieved a comprehensive and systematic understanding of the spatial layout of Buddhist and Taoist temples in Chengdu, which is of great significance to enrich the connotation of religious architecture culture and improve the local culture of Sichuan
Predictive Model Degrees of Freedom in Linear Regression
Overparametrized interpolating models have drawn increasing attention from
machine learning. Some recent studies suggest that regularized interpolating
models can generalize well. This phenomenon seemingly contradicts the
conventional wisdom that interpolation tends to overfit the data and performs
poorly on test data. Further, it appears to defy the bias-variance trade-off.
As one of the shortcomings of the existing theory, the classical notion of
model degrees of freedom fails to explain the intrinsic difference among the
interpolating models since it focuses on estimation of in-sample prediction
error. This motivates an alternative measure of model complexity which can
differentiate those interpolating models and take different test points into
account. In particular, we propose a measure with a proper adjustment based on
the squared covariance between the predictions and observations. Our analysis
with least squares method reveals some interesting properties of the measure,
which can reconcile the "double descent" phenomenon with the classical theory.
This opens doors to an extended definition of model degrees of freedom in
modern predictive settings.Comment: 47 pages, 18 figure
Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance
Acknowledgements: The computations and data handling were enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC) at UPPMAX, Uppsala University, partially funded by the Swedish Research Council through grant agreement no. 2018-05973. This research has been conducted using the UK Biobank Resource under Application Number 22224. Funding: Open Access funding provided by Karolinska Institute. Open Access funding provided by Karolinska Institute. This work was financed by the Swedish Research Council (Grant 2018-02547, 2015-03255, 2019-01272, 2018-02077), the Swedish Cancer Society (Grants CAN 2016/684), the Stockholm County Council (Grant no. 20170088), the Karolinska Institutetâs Research Foundation (Grant 2018-02146), Karolinska Institutetâs Strategic Research Program in Epidemiology, King Gustaf V:s and Queen Victoria's Foundation of Freemasons, and the Ă
ke Wibergs Foundation (M19-0294). FG was a Leopoldina Postdoctoral Fellow (Grant no. LPDS 2018-06) funded by the Academy of Sciences Leopoldina. Correction to: Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance (Human Genetics, (2020), 10.1007/s00439-020-02249-w) The data were exclusively retrieved from the UK Biobank and can be accessed upon request from the UK Biobank. The mitochondrial DNA abundance as computed in this manuscript will be reported back to the UK Biobank upon publication. The scripts to compute the weights and the weighted mtDNA abundance in the UKB dataset will be published at https://github.com/GrassmannLab/MT_UKB.Peer reviewedPublisher PD
Beneficial roles of nutrients as immunostimulants in aquaculture: A review
Protein deficiency is a major difficulty for human needs in the past few decades, while different types of aquatic
species are rich in high quality protein. Therefore, aquaculture is considered as the main developing food production sector globally. Bacterial infections are the main problem for aquaculture, and their outbreaks have a
great impact on productivity, and previously indiscriminate use of antibiotics to control them. However, the
emergence of multidrug-resistant pathogens might lead to sudden infectious disease outbreaks resulting in
serious economic loss. Immunostimulants application is an effective technique to protect and enhance the immune system of aquatic animals and therefore improve aquaculture production. Nutrient immunostimulants such
as essential fatty acids, amino acids, vitamins, and minerals are the most important responsibility to improve
aquaculture production, as well as the cost of this method, which is effective, non-toxic, and environment
friendly. These nutrient immunostimulants are supportive to increase the immune system, antioxidant, antiinflammatory, and infection resistance of aquatic animals. In addition, nutritional feed additives improved
feed palatability and the excellence of aquatic products and also enhance gut functions. Some information is
available on nutrient immunostimulants in aquaculture applications, and this review provides information on
different kinds of nutritional administration used in aquaculture to enhance positive impacts on aquatic animalsâ
health as well as feed quality development. This review will provide theoretical references for the application of
nutrient immunostimulants in aquatic feeds
A Defect-Correction Method for Time-Dependent Viscoelastic Fluid Flow Based on SUPG Formulation
A defect-correction mixed finite element method for solving the time-dependent
Johnson-Segalman viscoelastic equations in two dimensions is given. In
the defect step, the constitutive equation is computed with the artificially
reduced Weissenberg parameter for stability, and the resulting residual is
corrected in the correction step on the same grid. A streamline upwind
Petrov-Galerkin (SUPG) approximation is used to stabilize the hyperbolic
character of the constitutive equation for the stress. We establish a priori
error estimates for the defect step and the first correction step of the defect
correction method. The derived theoretical results are supported by
numerical tests
Metformin attenuates lipid accumulation in hepatocytes of blunt snout bream (Megalobrama amblycephala) via activation of AMP-activated protein kinase
Currently, there is a trend to use high-fat diets in intensive aquaculture that is accompanied with incidence of fatty liver when dietary lipid level surpasses an upper limit. So, it is necessary to develop appropriate strategies to reduce the risk of fatty liver in commercial fish farming. Studies in mammals have revealed a correlation between fatty liver and AMP-activated protein kinase (AMPK) activity, which has been recognized as a key modulator of lipid metabolism. Considering the frequent occurrence of fatty liver in blunt snout bream farming, an in-vitro study was designed to evaluate the efficiency of metformin, as a stimulator of AMPK, in activation of AMPK and its subsequent effects on lipid metabolism in primary hepatocytes. Fish hepatocytes were seeded at a density of 1âŻĂâŻ106âŻmlâ1 in 6-well tissue culture plates and treated with three different media including: 1) Leibovitz's L-15 medium [L15] as control, 2) high-fat medium [L15âŻ+âŻ400âŻÎźM oleic acid], and 3) metformin medium [L15âŻ+âŻ400âŻÎźM oleic acid+200âŻÎźM metformin]. After 48âŻh of culture, the cells and supernatant were collected for analysis. The results showed significant (P
Comparison of generation 3 polyamidoamine dendrimer and generation 4 polypropylenimine dendrimer on drug loading, complex structure, release behavior, and cytotoxicity
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