Psikolojik beceri kıstası olarak özgüvenin, sporcuların başarı algısına katkısı ; güreş milli takım örneği

Bu tezin amacı; güreş milli takımlarında çeşitli dönemlerde yer almış ve halen güreş milli takımında bulunan 18 yaş üstü erkek güreşçilerin özgüven seviyelerinin başarı algılarına etkisinin incelenmesidir. Araştırmada; 18 yaş üstü erkek Güreş milli Takımı sporcularına yapılacak Özgüven Ölçeği ve Başarı Algısı envanteri yardımıyla, Türkiye Güreş Milli Takımlarında farklı zamanlarda bulunmuş ve halen güreş milli takımında olan 18 yaş üstü erkek güreşçilerin, spor hayatlarındaki kazanımlarında psikolojik yeteneklerden özgüvenin performanslarına ve başarılarına sağladığı yardımı belirlemektir.--------------------The aim of this thesis is to research the self confidence level of sportsmen who took part in national wrestling teams. By the help of this study the self confidence scale and success perception inventory of a sportsmen who took part in national wrestling team is measured through the psychological ability in their sports career and the contribution of their self confidence to their performance

Natrix tessellata’nın (Squamata: Colubridae) Duvernoy bezinde histolojik ve histokimyasal incelemeler

Temporal bölgede konumlanan ve oral bir bez olan Duvernoy bezi sadece colubrid yılanlarda bulunur. Bu çalışma Natrix tessellata (Laurenti, 1768)’da Duvernoy beziyle ilgili ilk morfolojik ve histolojik çalışmadır. Bez bağ dokusu tarafından kuşatılır. Bağ dokusu bezin iç kısımlarına uzanarak asinuslar ve iç salgı kanallarını da kuşatarak lobulleri oluşturur. Duvernoy bezi seromukoz hücrelerden oluşan seromukoz asinuslar ve mukoz hücrelerden oluşan mukoz asinuslardan oluşur. Asinuslar histokimyasal özelliklerine göre karakterize edilirler. Bez temel olarak seromukoz asinuslardan oluşurken, mukoz hücreler bezin merkezi ve iç salgı kanalı etrafı ile sınırlı kalır.Duvernoy’s gland, an oral gland located in temporal region, is only found in Colubrid snakes. This is the first report describing morphological and histological structure of Duvernoy’s gland in Natrix tessellata (Laurenti, 1768). It is surrounded by a connective tissue layer which penetrates into the gland by forming many septa, dividing the glandular body into lobules and including the acini and the inner ducts. Duvernoy’s gland is formed by seromucous acini composed of seromucous cells, and mucous acini composed of mucous cells and they are recognized by their histochemical characteristics. The gland is mainly organized in seromucous acini, mucous cells are restricted to the gland center region and to the inner secretion duct lining epithelium

The effect of HBB:c.*+96T>C (3'UTR +1570 T>C) on the mild β-thalassemia intermedia phenotype

Abstract Hemoglobin beta (HBB):c.*+96T>C substitution is very rare among β-globin gene mutations and its clinical significance remains to be clarified. The present study aimed to investigate the role of HBB:c.*+96T>C in the β-thalassemia intermedia phenotype in a Turkish family. The proband and parents were screened for β-globin gene mutations via direct sequencing. Hematological and physical examination results were recorded, and correlated according to genotype. The proband was compound heterozygous for Cod 8 (-AA) and HBB:c.*+96T>C, whereas his mother and father were heterozygous for Cod 8 (-AA) and HBB:c.*+96T>C, respectively. The father had almost normal hematological findings, whereas the mother had the typical β-thalassemia trait phenotype. The proband was diagnosed as mild β-thalassemia intermedia based on hepatosplenomegaly and hematological findings. To the best of our knowledge this is the first report of HBB:c.*+96T>C mutation in a Turkish family. HBB:c.* 96T>C substitution is a very rare, but clinically relevant β-globin gene mutation. Additionally, we think that if 1 spouse is a carrier for β-globin gene mutation the other should be screened for silent mutations, such as HBB:c.*+96T>C mutation of the β-globin gene, even if she/he does not have any clinical or hematological signs of the β-thalassemia trait phenotype. (Turk J Hematol 2011; 28: 219-22) Key words: Mild β-thalassemia intermedia, β-globin gene, HBB:c.*+96T>

FMR1 Gene Mutation Analysis and CGG Repeat Number Distribution from a Single Center

Background: Mutation occurring in fragile X mental retardation 1 (FMR1) gene is acknowledged as the most common cause for X chromosome linked intellectual disability/mental retardation (XLID/XLMR). This gene harbors unstable CGG triplet repeats within its 5'UTR (untranslated region). Loss of function of the FMR1, which is mostly due to the hypermethylation of the CpG islands on its promoter region, causes fragile X syndrome (FXS). Displaying different frequencies, the FXS is a common phenomenon all over the world, the studies focus mostly on the Caucasian population. Purpose: We aimed to reveal the CGG repeat number distribution and the mutation profile of the FMR1 gene in clinically pre-diagnosed FXS patients and in family members of the patients who were diagnosed as full mutation. Methods: We evaluated the copy number of the CGG triplets in 767 FXS patients and their family members in Antalya province by employing fragment analysis molecular technique. We also assessed, by segregation analysis, whether there is unusual genetic transmission pattern of CGGs. Results: The molecular analysis shows the most common copy numbers of CGGs are thirty, twenty-nine and thirty-one. Present study is the first report concerning Antalya city of Turkey about the frequencies of the normal CGG repeats number, grey-zone, pre-mutation and full mutations, we updated our molecular test results with two unusual transmittance patterns of the CGG repeats. Conclusion: Since the potential of CGG repeat properties may cause differential intergenerational transmission patterns, its' population specific evaluation can contribute to provide a better genetic diagnosis and genetic counseling services for the related clinical entities

Investigation of Alpha Globin Gene Mutations byComplementary Methods in Antalya

Alpha (?) thalassemia is one of the hemoglobinopaties that is inherited by autosomal recessive mode. It is caused by mutations on alpha-1 and alpha-2 globin genes. Deletional type mutations of globin genes have commonly been seen in alpha thalassemias. While small deletional mutations such as -3.7 cause ?+-thalassemia, large deletions such as -26.5 -20.5 cause ?0-thalassemia. The objective of our study was to determine the profile of deletional and non-deletional ?-globin gene mutations in the Antalya population, Turkey.In present study, the presence of ?-thalassemia mutations were investigated by RDBH (reverse dot blot hybridization) among 250 patients with microcytic anemia and beta globin normal. Some positive and negative cases were confirmed by MLPA (multiplex ligation dependent probe amplification) and at the latest DNA sequencing. Eight different mutations were determined in 112 (44.8%) of patients in our study. The -??3.7 deletion was the most common mutation(73.3%). Others common mutations were the – ? 20.5 (13.0%) and –MED (6.5%), --FIL (2.4%), Hb Adana (2.4%). The 97.5 % of total mutations consisted of these five mutations. Three patients with Hb H disease were found related with - ? 3.7 /-(?) -20.5 genotype. One patient (2.04%) had the ??? anti-3.7 gene triplication. Two rare mutations, ?2 codon 64 (G>C) (Hb Fontainebleau) and ?2 codon 193 (G>A) (Hb G- Waimanalo), were determined by DNA sequencing firstly in Antalya Province, Turkey.Our results may be valuable to give accurate premarital genetic counseling and to apply classical prenatal and preimplantation genetic diagnosis by the complementary methods such as RDBH, MLPA and DNA sequencing for the screening of alpha thalassemia carriers