2,147 research outputs found
Neutral theory of chemical reaction networks
To what extent do the characteristic features of a chemical reaction network
reflect its purpose and function? In general, one argues that correlations
between specific features and specific functions are key to understanding a
complex structure. However, specific features may sometimes be neutral and
uncorrelated with any system-specific purpose, function or causal chain. Such
neutral features are caused by chance and randomness. Here we compare two
classes of chemical networks: one that has been subjected to biological
evolution (the chemical reaction network of metabolism in living cells) and one
that has not (the atmospheric planetary chemical reaction networks). Their
degree distributions are shown to share the very same neutral
system-independent features. The shape of the broad distributions is to a large
extent controlled by a single parameter, the network size. From this
perspective, there is little difference between atmospheric and metabolic
networks; they are just different sizes of the same random assembling network.
In other words, the shape of the degree distribution is a neutral
characteristic feature and has no functional or evolutionary implications in
itself; it is not a matter of life and death.Comment: 13 pages, 8 figure
Investigation of inversion, accumulation and junctionless mode bulk Germanium FinFETs
The characteristic performance of n-type and p-type inversion (IM) mode, accumulation (AC) mode and junctionless (JL) mode, bulk Germanium FinFET device with 3-nm gate length (LG) are demonstrated by using 3-D quantum transport device simulation. The simulated bulk Ge FinFET device exhibits favorable short channel characteristics, including drain-induced barrier lowering (DIBL<10mV/V), sub threshold slope (SS∼64mV/dec.). Electron density distributions in ON-state and OFF-state also show that the simulated devices have large ION/IOFF ratios. Homogenous source/drain doping is maintained and only the channel doping is varied among different operating modes. Also, a constant threshold voltage |VTH|∼0.31V is maintained. Moreover, the calculated quantum capacitance (CQ) values of the Ge nanowire emphasizes the importance of quantum confinement effects (QCE) on the performance of the ultra-scaled devices
Recommended from our members
\u3cem\u3ePseudomonas aeruginosa\u3c/em\u3e reverse diauxie is a multidimensionl, optimized, resource utilization strategy
Pseudomonas aeruginosa is a globally-distributed bacterium often found in medical infections. The opportunistic pathogen uses a different, carbon catabolite repression (CCR) strategy than many, model microorganisms. It does not utilize a classic diauxie phenotype, nor does it follow common systems biology assumptions including preferential consumption of glucose with an ‘overflow’ metabolism. Despite these contradictions, P. aeruginosa is competitive in many, disparate environments underscoring knowledge gaps in microbial ecology and systems biology. Physiological, omics, and in silico analyses were used to quantify the P. aeruginosa CCR strategy known as ‘reverse diauxie’. An ecological basis of reverse diauxie was identified using a genome-scale, metabolic model interrogated with in vitro omics data. Reverse diauxie preference for lower energy, nonfermentable carbon sources, such as acetate or succinate over glucose, was predicted using a multidimensional strategy which minimized resource investment into central metabolism while completely oxidizing substrates. Application of a common, in silico optimization criterion, which maximizes growth rate, did not predict the reverse diauxie phenotypes. This study quantifies P. aeruginosa metabolic strategies foundational to its wide distribution and virulence including its potentially, mutualistic interactions with microorganisms found commonly in the environment and in medical infections
Domain Walls and Flux Tubes in N=2 SQCD: D-Brane Prototypes
This paper could have been entitled "D branes and strings from flesh and
blood." We study field theoretic prototypes of D branes/strings. To this end we
consider (2+1)-dimensional domain walls in (3+1)-dimensional N=2 SQCD with
SU(2) gauge group and two quark flavors in the fundamental representation. This
theory is perturbed by a small mass term of the adjoint matter which, in the
leading order in the mass parameter, does not break N=2 supersymmetry, and
reduces to a (generalized) Fayet-Iliopoulos term in the effective low-energy
N=2 SQED. We find 1/2 BPS-saturated domain wall solution interpolating between
two quark vacua at weak coupling, and show that this domain wall localizes a
U(1) gauge field. To make contact with the brane/string picture we consider the
Abrikosov-Nielsen-Olesen magnetic flux tube in one of two quark vacua and
demonstrate that it can end on the domain wall. We find an explicit 1/4
BPS-saturated solution for the wall/flux tube junction. We verify that the end
point of the flux tube on the wall plays the role of an electric charge in the
dual (2+1)-dimensional SQED living on the wall. Flow to N=1 theory is
discussed. Our results lead us to a conjecture regarding the notorious "missing
wall" in the solution of Kaplunovsky et al.Comment: 41 pages, 5 figures, Sect. 9.3 expanded, typos correcte
Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases
The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated tissue injury, most notably systemic lupus erythematosus (SLE). Paradoxically, a complete deficiency of an early component of the CP, as evidenced by homozygous genetic deficiencies reported in human, are strongly associated with the risk of developing SLE or a lupus-like disease. Similarly, isotype deficiency attributable to a gene copy number variation, and/or the presence of autoantibodies directed against a CP component or a regulatory protein that result in an acquired deficiency are relatively common in SLE patients. Applying accurate assay methodologies with rigorous data validations, low gene copy numbers of total C4, heterozygous and homozygous deficiencies of C4A have been shown as medium to large effect size risk factors, while high copy numbers of total C4 or C4A as prevalent protective factors, of European and East-Asian SLE. Here, we summarize the current knowledge related to genetic deficiency and insufficiency, and acquired protein alterations for C1q, C1r, C1s, C4A/C4B, and C2 in disease pathogenesis and prognosis of SLE, and, briefly, for other systemic autoimmune diseases. As the complement system is increasingly found to be associated with autoimmune diseases, it has become an attractive therapeutic target. We highlight the recent developments and offer a balanced perspective concerning future investigations and therapeutic applications with a focus on early components of the CP in human systemic autoimmune diseases
Incidence and drug treatment of emotional distress after cancer diagnosis : a matched primary care case-control study
Notes This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.Peer reviewedPublisher PD
Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants
Giant nonlinear optical responses from photon avalanching nanoparticles
Avalanche phenomena leverage steeply nonlinear dynamics to generate
disproportionately high responses from small perturbations and are found in a
multitude of events and materials, enabling technologies including optical
phase-conjugate imaging, infrared quantum counting, and efficient upconverted
lasing. However, the photon avalanching (PA) mechanism underlying these optical
innovations has been observed only in bulk materials and aggregates, and
typically at cryogenic temperatures, limiting its utility and impact. Here, we
report the realization of PA at room temperature in single
nanostructures--small, Tm-doped upconverting nanocrystals--and demonstrate
their use in superresolution imaging at near-infrared (NIR) wavelengths within
spectral windows of maximal biological transparency. Avalanching nanoparticles
(ANPs) can be pumped by continuous-wave or pulsed lasers and exhibit all of the
defining features of PA. These hallmarks include excitation power thresholds,
long rise time at threshold, and a dominant excited-state absorption that is
>13,000x larger than ground-state absorption. Beyond the avalanching threshold,
ANP emission scales nonlinearly with the 26th power of pump intensity. This
enables the realization of photon-avalanche single-beam superresolution imaging
(PASSI), achieving sub-70 nm spatial resolution using only simple scanning
confocal microscopy and before any computational analysis. Pairing their steep
nonlinearity with existing superresolution techniques and computational
methods, ANPs allow for imaging with higher resolution and at ca. 100-fold
lower excitation intensities than is possible with other probes. The low PA
threshold and exceptional photostability of ANPs also suggest their utility in
a diverse array of applications including sub-wavelength bioimaging, IR
detection, temperature and pressure transduction, neuromorphic computing, and
quantum optics.Comment: 14 pages, 4 figure
- …