SUBARU Near-Infrared Multi-Color Images of Class II Young Stellar Object, RNO91

We conducted sub-arcsecond near-infrared imaging observations of RNO91 with CIAO mounted on the SUBARU 8.2 m telescope. We present our JHK band data along with optical images, which when considered together reveal a complex circumstellar structure. We examined the colors of associated nebula and compared the geometry of the outflow/disk system suggested by our data with that already proposed on the basis of previous studies. Our K-band image shows bright circumstellar nebulosity detected within 2"(300AU) around the central source while it is less conspicuous at shorter wavelengths such as J and optical. P.A. and size of this red color nebulosity in our H-K color image agree with those of the previously detected polarization disk. These data agreement indicate that this bright circumstellar nebulosity region which follows the reddening law might be attributed to a disk-like structure. At J and optical wavelengths, several blue knot-like structures are detected around and beyond the bright circumstellar nebulosity. We suggest that these knotty reflection nebulae may represent disintegrating fragments of an infalling envelope. The three-color composite image has an appearance of arc-shaped nebulosity extending to the north and to the east through the central source. On the other end of this arc-shaped structure, the nebula appears to become more extended (2."3 long) to the southwest. We interpret these structures as roots of bipolar cavities opening to the northeast and southwest. The complex distribution of reflection nebulosity seen around RNO91 appears to confirm the interpretation of this source as an object dispersing its molecular envelope while transitioning from protostar to T Tauri star.Comment: 18 pages, 6 figures, Accepted by Publications of the Astronomical Society of Japa

BIOMECHANICAL CONSIDERATIONS OF CMJ AND SQJ ON THE SAFETY MAT

The purpose of this study was to detect whether differences exist concerning the kinematic parameters of jump (SQJ and CMJ) on two different surfaces (RS and SS). Nine healthy students performed two jumps on two surfaces. Two factor repeated measure (ANOVA) was used for statistical analysis (

Effectiveness of Enteral Nutrition in Restoring on Immunocompetence Comparing with Naturl Oral Feeding in Malnourished Rats

A protocol for nutritional restoration with estimated amount of nutrients from malnourished state was set up by increasing protein intake at a week interval. Based on this protocol, recovery of hematological, biochemical and immunological parameters in rats nutritionally restored with per os natual diet (PD) and enteral tube feeding of Clinimeal (EN) was described. When these two nutrients were compared, body weight gains showed somewhat delay in EN group but Hb, Ht, and serum total protein level, C3 level, macrophage function and PPD skin reactivity were restored more rapidly and effectively in the group restored with EN than that with PD. From these points, it is preferable to restore the severe malnourished state with enteral nutrient, Clinimeal

Near-Infrared Coronagraphic Observations of the T Tauri Binary System UY Aur

We present a near-infrared image of UY Aur, a 0.9" separated binary system, using the Coronagraphic Imager with Adaptive Optics on the Subaru Telescope. Thanks to adaptive optics, the spatial resolution of our image was ~0.1" in the full width at half maximum of the point spread function, the highest achieved. By comparison with previous measurements, we estimated that the orbital period is ~1640 yrs and the total mass of the binary is ~1.73 solar mass. The observed H-band magnitude of the secondary varies by as much as 1.3 mag within a decade, while that of the primary is rather stable. This inconstancy may arise from photospheric variability caused by an uneven accretion rate or from the rotation of the secondary. We detected a half-ring shaped circumbinary disk around the binary with a bright southwest part but a barely detectable northeast portion. The brightness ratio is ~57. Its inner radius and inclination are about 520 AU and 42, respectively. The disk is not uniform but has remarkable features, including a clumpy structure along the disk, circumstellar material inside the inner cavity, and an extended armlike structure. The circumstellar material inside the cavity probably corresponds to a clump or material accreting from the disk onto the binary. The armlike structure is a part of the disk, created by the accretion from the outer region of the disk or encounters with other stellar systems.Comment: 16 pages, 6 figures; accepted for publication in A

RNA Modification in Inflammatory Bowel Diseases

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some populations with IBD show a cancer-prone phenotype. Recent studies have provided insight into the involvement of RNA modifications in the specific pathogenesis of IBD through regulation of RNA biology in epithelial and immune cells. Studies of several RNA modification-targeting reagents have shown preferable outcomes in patients with colitis. Here, we note a new awareness of RNA modification in the targeting of IBD and related diseases, which will contribute to early diagnosis, disease monitoring, and possible control by innovative therapeutic approaches

EEG resting-state networks in Alzheimer’s disease associated with clinical symptoms

Alzheimer’s disease (AD) is a progressive neuropsychiatric disease affecting many elderly people and is characterized by progressive cognitive impairment of memory, visuospatial, and executive functions. As the elderly population is growing, the number of AD patients is increasing considerably. There is currently growing interest in determining AD’s cognitive dysfunction markers. We used exact low-resolution-brain-electromagnetic-tomography independent-component-analysis (eLORETA-ICA) to assess activities of five electroencephalography resting-state-networks (EEG-RSNs) in 90 drug-free AD patients and 11 drug-free patients with mild-cognitive-impairment due to AD (ADMCI). Compared to 147 healthy subjects, the AD/ADMCI patients showed significantly decreased activities in the memory network and occipital alpha activity, where the age difference between the AD/ADMCI and healthy groups was corrected by linear regression analysis. Furthermore, the age-corrected EEG-RSN activities showed correlations with cognitive function test scores in AD/ADMCI. In particular, decreased memory network activity showed correlations with worse total cognitive scores for both Mini-Mental-State-Examination (MMSE) and Alzheimer’s Disease-Assessment-Scale-cognitive-component-Japanese version (ADAS-J cog) including worse sub-scores for orientation, registration, repetition, word recognition and ideational praxis. Our results indicate that AD affects specific EEG-RSNs and deteriorated network activity causes symptoms. Overall, eLORETA-ICA is a useful, non-invasive tool for assessing EEG-functional-network activities and provides better understanding of the neurophysiological mechanisms underlying the disease

Chronic Orofacial Pain in Dental Patients: Retrospective Investigation over 12 years

Orofacial pain is often difficult to diagnose and treat. However, there have been few reports on the clinical observation of dental patients with orofacial pain. We retrospectively investigated the characteristics of 221 dental patients who had suffered from persistent orofacial pain. Data were collected from the outpatient medical records in our clinic over the past 12 years. More than half of the patients (53.8%) had suffered with pain for more than 6 months from pain onset until the first visit to our clinic. The main diagnoses were neuropathic pain (30.3%), myofascial pain (23.5%), psychogenic pain (20.4%), odontogenic toothache (17.2%), and others (7.7%) such as temporomandibular disorders and glossitis. The treatments included pharmacotherapy, splint therapy, and others such as nerve block, dental treatment, physiotherapy, and/or psychotherapy. Excluding the patients (52 of 221 initially enrolled patients) with unknown responses to treatment, 65.7% showed remission or a significant improvement in pain in response to treatment. Although only a small group of patients had odontogenic toothache, the rate of improvement was highest for this disorder. In conclusion, early consultation with a dentist is useful to prevent chronicity of odontogenic pain and to make a differential diagnosis in patients with orofacial pain

Pancreatic Cancer Research beyond DNA Mutations

Pancreatic ductal adenocarcinoma (PDAC) is caused by genetic mutations in four genes: KRAS proto-oncogene and GTPase (KRAS), tumor protein P53 (TP53), cyclin-dependent kinase inhibitor 2A (CDKN2A), and mothers against decapentaplegic homolog 4 (SMAD4), also called the big 4. The changes in tumors are very complex, making their characterization in the early stages challenging. Therefore, the development of innovative therapeutic approaches is desirable. The key to overcoming PDAC is diagnosing it in the early stages. Therefore, recent studies have investigated the multifaced characteristics of PDAC, which includes cancer cell metabolism, mesenchymal cells including cancer-associated fibroblasts and immune cells, and metagenomics, which extend to characterize various biomolecules including RNAs and volatile organic compounds. Various alterations in the KRAS-dependent as well as KRAS-independent pathways are involved in the refractoriness of PDAC. The optimal combination of these new technologies is expected to help treat intractable pancreatic cancer