Introspectiveness of Higher Education Students: Study and Development

The change in strategic guidelines in Russian education is associated with a revision of the goals of teaching and upbringing. However, the emphasis of reforms has shifted towards the formation of the required professional competences at this stage in the development of the education system of the Russian Federation. We think that it is possible to achieve the set goal of higher education through the development of the introspectiveness as a quality of the personality of students. The formation of the introspectiveness in a future specialist will have an effect on the successful mastery, expansion and transformation of social experience, as well as the internal plan of action. Thus, demonstrating the formed introspectiveness as a personality trait, the student is able to organize his educational activities independently, activities to cognize the surrounding reality and his inner world, as well as self-determine in various life situations, including the development of general cultural and professional competences. In this regard, the emphasis in the issue of developing the introspectiveness of students is made on specifying the conditions that must be created at a higher education institution for the manifestation and formation of this personality quality. The purpose of the article is to study the level of the introspectiveness of university students and develop psychological and pedagogical conditions that develop this personality quality. The leading techniques for the study of this problem were the following: Q-sort Technique; the technique for diagnostics of an individual measure of the introspectiveness degree. At the stage of the ascertaining experiment, the levels of the introspectiveness of university students were revealed. The results of the ascertaining experiment convincingly demonstrated the need to organize special work to develop the introspectiveness of students. The authors substantiated that the success of developing students’ introspectiveness is ensured by the created psychological and pedagogical conditions. A model of developing the introspectiveness as a personality quality of a future professional has been developed and tested. The results of this study create opportunities for further development of the problem in the context of the organization of lectures in the learning process for students of different courses and types of specialization. The article is intended for psychologists, tutors, education managers

Introspectiveness of Higher Education Students: Study and Development

The change in strategic guidelines in Russian education is associated with a revision of the goals of teaching and upbringing. However, the emphasis of reforms has shifted towards the formation of the required professional competences at this stage in the development of the education system of the Russian Federation. We think that it is possible to achieve the set goal of higher education through the development of the introspectiveness as a quality of the personality of students. The formation of the introspectiveness in a future specialist will have an effect on the successful mastery, expansion and transformation of social experience, as well as the internal plan of action. Thus, demonstrating the formed introspectiveness as a personality trait, the student is able to organize his educational activities independently, activities to cognize the surrounding reality and his inner world, as well as self-determine in various life situations, including the development of general cultural and professional competences. In this regard, the emphasis in the issue of developing the introspectiveness of students is made on specifying the conditions that must be created at a higher education institution for the manifestation and formation of this personality quality. The purpose of the article is to study the level of the introspectiveness of university students and develop psychological and pedagogical conditions that develop this personality quality. The leading techniques for the study of this problem were the following: Q-sort Technique; the technique for diagnostics of an individual measure of the introspectiveness degree. At the stage of the ascertaining experiment, the levels of the introspectiveness of university students were revealed. The results of the ascertaining experiment convincingly demonstrated the need to organize special work to develop the introspectiveness of students. The authors substantiated that the success of developing students’ introspectiveness is ensured by the created psychological and pedagogical conditions. A model of developing the introspectiveness as a personality quality of a future professional has been developed and tested. The results of this study create opportunities for further development of the problem in the context of the organization of lectures in the learning process for students of different courses and types of specialization. The article is intended for psychologists, tutors, education managers.El cambio en las pautas estratégicas en la educación rusa está asociado con una revisión de los objetivos de la enseñanza y la educación. Sin embargo, el énfasis de las reformas se ha desplazado hacia la formación de las competencias profesionales necesarias en esta etapa del desarrollo del sistema educativo de la Federación de Rusia. Pensamos que es posible lograr el objetivo planteado de la educación superior a través del desarrollo de la introspectividad como una cualidad de la personalidad de los estudiantes. La formación de la introspectividad en un futuro especialista tendrá un efecto en el dominio, expansión y transformación exitosa de la experiencia social, así como en el plan de acción interno. Así, demostrando la introspectividad formada como un rasgo de personalidad, el estudiante es capaz de organizar sus actividades educativas de forma independiente, actividades para conocer la realidad circundante y su mundo interior, así como autodeterminarse en diversas situaciones de la vida, incluido el desarrollo de la cultura general. y competencias profesionales. En este sentido, el énfasis en el tema del desarrollo de la introspectividad de los estudiantes se hace en especificar las condiciones que deben crearse en una institución de educación superior para la manifestación y formación de esta cualidad de personalidad. El propósito del artículo es estudiar el nivel de introspectividad de los estudiantes universitarios y desarrollar las condiciones psicológicas y pedagógicas que desarrollan esta cualidad de personalidad. Las principales técnicas para el estudio de este problema fueron las siguientes: técnica de Q-sort; la técnica para el diagnóstico de una medida individual del grado de introspectividad. En la etapa del experimento de determinación, se revelaron los niveles de introspectividad de los estudiantes universitarios. Los resultados del experimento de comprobación demostraron de manera convincente la necesidad de organizar un trabajo especial para desarrollar la introspectividad de los estudiantes. Los autores corroboraron que el éxito en el desarrollo de la introspectividad de los estudiantes está garantizado por las condiciones psicológicas y pedagógicas creadas. Se ha desarrollado y probado un modelo de desarrollo de la introspectividad como cualidad de personalidad de un futuro profesional. Los resultados de este estudio crean oportunidades para un mayor desarrollo del problema en el contexto de la organización de conferencias en el proceso de aprendizaje para estudiantes de diferentes cursos y tipos de especialización. El artículo está dirigido a psicólogos, tutores, gestores educativos

Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401

Ten new diterpene glycosides virescenosides Z9-Z18 (1–10) together with three known analogues (11–13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassium bromide. Structures of the isolated metabolites were established based on spectroscopic methods. The effects of some isolated glycosides and aglycons 15–18 on urease activity and regulation of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) production in macrophages stimulated with lipopolysaccharide (LPC) were evaluated

Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668

Six new carotane sesquiterpenoids piltunines A–F (1–6) together with known compounds (7–9) were isolated from the marine-derived fungus Penicillium piltunense KMM 4668. Their structures were established using spectroscopic methods. The absolute configurations of 1–7 were determined based on circular dichroism (CD) and nuclear Overhauser spectroscopy (NOESY) data as well as biogenetic considerations. The cytotoxic activity of some of the isolated compounds and their effects on regulation of reactive oxygen species (ROS) and nitric oxide (NO) production in lipopolysaccharide-stimulated macrophages were examined

New Marine Fungal Deoxy-14,15-Dehydroisoaustamide Resensitizes Prostate Cancer Cells to Enzalutamide

Marine fungi serve as a valuable source for new bioactive molecules bearing various biological activities. In this study, we report on the isolation of a new indole diketopiperazine alkaloid deoxy-14,15-dehydroisoaustamide (1) from the marine-derived fungus Penicillium dimorphosporum KMM 4689 associated with a soft coral. The structure of this metabolite, including its absolute configuration, was determined by HR-MS, 1D and 2D NMR as well as CD data. Compound 1 is a very first deoxyisoaustamide alkaloid possessing two double bonds in the proline ring. The isolated compound was noncytotoxic to a panel of human normal and cancer cell lines up to 100 µM. At the same time, compound 1 resensitized prostate cancer 22Rv1 cells to androgen receptor (AR) blocker enzalutamide. The mechanism of this phenomenon was identified as specific drug-induced degradation of androgen receptor transcription variant V7 (AR-V7), which also resulted in general suppression of AR signaling. Our data suggest that the isolated alkaloid is a promising candidate for combinational therapy of castration resistant prostate cancer, including drug-resistant subtypes

Cytotoxic Drimane-Type Sesquiterpenes from Co-Culture of the Marine-Derived Fungi <i>Aspergillus carneus</i> KMM 4638 and <i>Beauveria felina</i> (=<i>Isaria felina</i>) KMM 4639

Chemical investigation of a coculture of the marine-derived fungi Beauveria felina KMM 4639 and Aspergillus carneus KMM 4638 led to the identification of three new drimane-type sesquiterpenes, asperflavinoids B, D and E (2, 4, 5), and nine previously reported related compounds. The structures of these compounds were established using spectroscopic methods and by comparison with known analogues. We also investigated the cytotoxic activity of the isolated compounds against several cancer and normal cell lines. Asperflavinoid C (3) and ustusolate E (9) exerted a significant effect on human breast cancer MCF-7 cell viability, with IC50 values of 10 µM, and induced in caspase-dependent apoptosis and arrest of the MCF-7 cell cycle in the G2/M phase in these cells