Regulation of Inwardly Rectifying K Channels in Retinal Pigment Epithelial Cells by Intracellular pH

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66255/1/jphysiol.2003.042341.pd

Quantum Computing Quantum Monte Carlo

Quantum computing and quantum Monte Carlo (QMC) are respectively the state-of-the-art quantum and classical computing methods for understanding many-body quantum systems. Here, we propose a hybrid quantum-classical algorithm that integrates these two methods, inheriting their distinct features in efficient representation and manipulation of quantum states and overcoming their limitations. We first introduce non-stoquasticity indicators (NSIs) and their upper bounds, which measure the sign problem, the most notable limitation of QMC. We show that our algorithm could greatly mitigate the sign problem, which decreases NSIs with the assistance of quantum computing. Meanwhile, the use of quantum Monte Carlo also increases the expressivity of shallow quantum circuits, allowing more accurate computation that is conventionally achievable only with much deeper circuits. We numerically test and verify the method for the N$_2$ molecule (12 qubits) and the Hubbard model (16 qubits). Our work paves the way to solving practical problems with intermediate-scale and early-fault tolerant quantum computers, with potential applications in chemistry, condensed matter physics, materials, high energy physics, etc

A survey on human performance capture and animation

With the rapid development of computing technology, three-dimensional (3D) human body models and their dynamic motions are widely used in the digital entertainment industry. Human perfor- mance mainly involves human body shapes and motions. Key research problems include how to capture and analyze static geometric appearance and dynamic movement of human bodies, and how to simulate human body motions with physical e�ects. In this survey, according to main research directions of human body performance capture and animation, we summarize recent advances in key research topics, namely human body surface reconstruction, motion capture and synthesis, as well as physics-based motion sim- ulation, and further discuss future research problems and directions. We hope this will be helpful for readers to have a comprehensive understanding of human performance capture and animatio

Data-driven weight optimization for real-time mesh deformation

3D model deformation has been an active research topic in geometric processing. Due to its efficiency, linear blend skinning (LBS) and its follow-up methods are widely used in practical applications as an efficient method for deforming vector images, geometric models and animated characters. LBS needs to determine the control handles and specify their influence weights, which requires expertise and is time-consuming. Further studies have proposed a method for efficiently calculating bounded biharmonic weights of given control handles which reduces user effort and produces smooth deformation results. The algorithm defines a high-order shape-aware smoothness function which tends to produce smooth deformation results, but fails to generate locally rigid deformations. To address this, we propose a novel data-driven approach to producing improved weights for handles that makes full use of available 3D model data by optimizing an energy consisting of data-driven, rigidity and sparsity terms, while maintaining its advantage of allowing handles of various forms. We further devise an efficient iterative optimization scheme. Through contrast experiments, it clearly shows that linear blend skinning based on our optimized weights better reflects the deformation characteristics of the model, leading to more accurate deformation results, outperforming existing methods. The method also retains real-time performance even with a large number of deformation examples. Our ablation experiments also show that each energy term is essential

Decoupling Control for Dual-Winding Bearingless Switched Reluctance Motor Based on Improved Inverse System Method

Dual-winding bearingless switched reluctance motor (BSRM) is a multivariable high-nonlinear system characterized by strong coupling, and it is not completely reversible. In this paper, a new decoupling control strategy based on improved inverse system method is proposed. Robust servo regulator is adopted for the decoupled plants to guarantee control performances and robustness. A phase dynamic compensation filter is also designed to improve system stability at high-speed. In order to explain the advantages of the proposed method, traditional methods are compared. The tracking and decoupling characteristics as well as disturbance rejection and robustness are deeply analyzed. Simulation and experiments results show that the decoupling control of dual-winding BSRM in both reversible and irreversible domains can be successfully resolved with the improved inverse system method. The stability and robustness problems induced by inverse controller can be effectively solved by introducing robust servo regulator and dynamic compensation filter

Tensor-network-assisted variational quantum algorithm

Near-term quantum devices generally suffer from shallow circuit depth and hence limited expressivity due to noise and decoherence. To address this, we propose tensor-network-assisted parametrized quantum circuits, which concatenate a classical tensor-network operator with a quantum circuit to effectively increase the circuit's expressivity without requiring a physically deeper circuit. We present a framework for tensor-network-assisted variational quantum algorithms that can solve quantum many-body problems using shallower quantum circuits. We demonstrate the efficiency of this approach by considering two examples of unitary matrix-product operators and unitary tree tensor networks, showing that they can both be implemented efficiently. Through numerical simulations, we show that the expressivity of these circuits is greatly enhanced with the assistance of tensor networks. We apply our method to two-dimensional Ising models and one-dimensional time-crystal Hamiltonian models with up to 16 qubits and demonstrate that our approach consistently outperforms conventional methods using shallow quantum circuits.Comment: 12 pages, 8 figures, 37 reference

An elastic-viscoplastic creep model for describing creep behavior of layered rock

To describe the full-stage creep behavior of layered rock accurately, a new elastic-viscoplastic creep model is proposed based on fractional order theory in this manuscript, which consists of a Hooke elastomer, a fractional Abel dashpot, a Kelvin body, and a new non-linear visco-plastic component. The non-linear creep model can not only describe the changes in three creep stages (primary creep, steady-state creep and accelerating creep) but also reflect the influence of different bedding angles of rock. The constitutive equations of the non-linear creep model are deduced by the empirical model method and plastic theory method, respectively. The parameters of the non-linear creep model are identified using the Levenberg-Marquardt algorithm from Origin. It shows that the creep model in this paper are highly consistent with the experimental data under different load levels, creep stages and bedding angles, and the accuracy and rationality of the model are verified. Moreover, the creep constitutive equations for layered rock derived by the two methods have the same fitting effect on the same set of experimental data

Sequence homolog-based molecular engineering for shifting the enzymatic pH optimum

AbstractCell-free synthetic biology system organizes multiple enzymes (parts) from different sources to implement unnatural catalytic functions. Highly adaption between the catalytic parts is crucial for building up efficient artificial biosynthetic systems. Protein engineering is a powerful technology to tailor various enzymatic properties including catalytic efficiency, substrate specificity, temperature adaptation and even achieve new catalytic functions. However, altering enzymatic pH optimum still remains a challenging task. In this study, we proposed a novel sequence homolog-based protein engineering strategy for shifting the enzymatic pH optimum based on statistical analyses of sequence-function relationship data of enzyme family. By two statistical procedures, artificial neural networks (ANNs) and least absolute shrinkage and selection operator (Lasso), five amino acids in GH11 xylanase family were identified to be related to the evolution of enzymatic pH optimum. Site-directed mutagenesis of a thermophilic xylanase from Caldicellulosiruptor bescii revealed that four out of five mutations could alter the enzymatic pH optima toward acidic condition without compromising the catalytic activity and thermostability. Combination of the positive mutants resulted in the best mutant M31 that decreased its pH optimum for 1.5 units and showed increased catalytic activity at pH < 5.0 compared to the wild-type enzyme. Structure analysis revealed that all the mutations are distant from the active center, which may be difficult to be identified by conventional rational design strategy. Interestingly, the four mutation sites are clustered at a certain region of the enzyme, suggesting a potential “hot zone” for regulating the pH optima of xylanases. This study provides an efficient method of modulating enzymatic pH optima based on statistical sequence analyses, which can facilitate the design and optimization of suitable catalytic parts for the construction of complicated cell-free synthetic biology systems