Secondary Parkinsonism in a Patient With a Cerebral Cavernous Hemangioma Treated With Stereotactic Radiosurgery

Secondary parkinsonism is defined with some symptoms similar to idiopathic Parkinson's disease, but with different etiologies. And cerebral cavernous hemangioma is one of the rare cases. A 51-year-old, male patient was consulted with tremor, rigidity and bradykinesia on the right upper extremity. The Hoehn and Yahr Parkinson's scale was Stage.. Radiological evaluations showed a deep-seated cerebral cavernous hemangioma at the left posterior insular region. The patient received stereotactic radiosurgery (CyberKnife (R), Accuray Incorporated, Sunnyvale, CA, USA). Clinical and radiological improvements revealed within follow-up, respectively. Stereotactic radiosurgery may be an alternative treatment for secondary parkinsonism by reducing the risk of re-bleeding and reducing its size

Posterior tibial slope as a risk factor for anterior cruciate ligament rupture in soccer players

WOS: 000297264400025PubMed ID: 24149571Anterior cruciate ligament (ACL) is the primary stabilizer of the knee. An impairment of any of the dynamic or static stability providing factors can lead to overload on the other factors and ultimately to deterioration of knee stability. This can result in anterior tibial translation and rupture of the ACL. The purpose of this study was to examine the influence of tibial slope on ACL injury risk on soccer players. A total of 64 elite soccer players and 45 sedentary controls were included in this longitudinal and controlled study. The angle between the tibial mid-diaphysis line and the line between the anterior and posterior edges of the medial tibial plateau was measured as the tibial slope via lateral radiographs. Individual player exposure, and injuries sustained by the participants were prospectively recorded. Eleven ACL injuries were documented during the study period. Tibial slope was not different between soccer players and sedentary controls. Tibial slope in the dominant and non-dominant legs was greater for the injured players compared to the uninjured players. The difference reached a significant level only for the dominant legs (p 0.05), a higher tibial slope was observed in dominant legs of injured players (p < 0.05). Higher tibial slope on injured soccer players compared to the uninjured ones supports the idea that the tibial slope degree might be an important risk factor for ACL injury

The First Finding of Cirrhosis: Hepatic Hydrothorax Caused by Absence of Ascites

Hepatic hydrothorax is a pleural effusion occurs in cirrhotic patients without any cardiac and pulmonary disease. Generally it shows up in acidic cases. The most of the cases show up on the right side whereas it rarely shows up on the left and on both sides. Its treatments are salt restriction, diuretic medication and therapeutic thoracentesis. In resistant cases pleurodesis, videothoracoscopic repair of defects, transjugular intrahepatic portosystemic shunt (TIPS) as well as liver transplantation in end stage hepatic cirrhosis patients can be done. In this article, we presented a 54 year old female case with hepatic cirrhosis and hydrothorax without ascites, admitting to clinic because of dyspnea. [Med-Science 2015; 4(2.000): 2276-80

Association of eNOS Gene Polymorphisms G894T and T-786C with Risk of Hepatorenal Syndrome

Background. There are no studies investigating the relationship between endothelial nitric oxide synthase (eNOS) gene polymorphisms and hepatorenal syndrome (HRS). Aim. The purpose of this study is to elucidate whether eNOS gene polymorphisms (G894T and T-786C) play a role in the development of type-2 HRS. Methods. This study was carried out in a group of 92 patients with cirrhosis (44 patients with type-2 HRS and 48 without HRS) and 50 healthy controls. Polymorphisms were determined by polymerase chain reaction (PCR) and melting curve analysis. Results. We did not find any significant difference in allele and genotype distributions of the eNOS -T-786C polymorphism among the groups ( = 0.440). However, the frequency of GT (40.9%) and TT (13.6%) genotypes and mutant allele T (34.1%) for the eNOS G894T polymorphism were significantly higher ( &lt; 0.001 and &lt; 0.001, resp.) in the HRS group than in both the stable cirrhosis (14.6%, 4.2%, and 11.5%, resp.) and the control (22.0%, 2.0%, and 13.0%, resp.) groups. Conclusion. The occurrence of mutant genotypes (GT/TT) and mutant allele T in eNOS -G894T polymorphisms should be considered as a potential risk factor in cirrhotic patients with HRS

Determining Toxoplasma high-risk autologous and allogeneic hematopoietic stem cell transplantation patients by systematic pre-transplant PCR screening of stem cell originated buffy coat

WOS: 000309376800009PubMed ID: 22609887The diagnosis of Toxoplasma infection or disease in hematopoietic stem cell transplantation (HSCT) patients is achieved mainly by PCR screening; however screening did not find wide field of use in practice due to costly expenditures of PCR. This study aimed to determine patients at high risk of Toxoplasma infection or disease before transplantation by stem cell originated buffy coat PCR and subsequently to screen them. Buffy coats collected from 12 autologous and 18 allogeneic HSCF patients' donors were investigated by PCR before transplantation. After transplantation, blood and sera collected at fixed time intervals were screened by two PCR methods and serological assays. Screening results first time assessed a toxoplasmosis incidence level as 25% in autologous HSCT patients and increased incidence level in allogeneic HSCT patients to 22%. Importantly, huffy coat PCR was first time performed before transplantation, to determine the risk of toxoplasmosis. Buffy coat PCR results showed that four patients were at high risk of toxoplasmosis before transplantation. After transplantation, these patients experienced toxoplasmosis. In conclusion, for the determination of patients at risk of toxoplasmosis, clinicians should consider buffy coat PCR in combination with serology before transplantation. After transplantation, PCR screening can be initiated in high risk patients upon clinical suspicion. (C) 2012 Elsevier Ireland Ltd. All rights reserved.Scientific Research Projects Branch Directorate of Ege University, TurkeyEge University [2005-TIP-032]The study was supported by the grant given by the Scientific Research Projects Branch Directorate of Ege University, Turkey (Grant 2005-TIP-032) to Y.G

Steatohepatitis Coexisting with Dubin Johnson Syndrome: A Case Report

Dubin-Johnson syndrome (DJS) is a benign autosomal recessive liver disorder characterised by an intermittent jaundice caused by chronic and conjugated hyperbilirubinaemia. Many mutations in multidrug resistance associated protein (MRP-2) gene have been identified in patients with DJS. Although the disease is usually asymptomatic, some patients may experience vague abdominal pain. In this report, we present a patient with steatohepatitis diagnosed as DJS through a liver biopsy. The patient, 38 years of age, male was admitted to our clinic with vague abdominal pain and jaundice. High levels of serum transaminase, triglyceride, cholesterol and bilirubin were found. Ultrasonography showed Grade II hepatosteatosis in the liver. When steatohepatitis and intracytoplasmic dPAS positive pigment which is more prominent in the perivenular region (zone 3) was observed in the liver biopsy, the patient was diagnosed as DJS coexisting with steatohepatitis. [Med-Science 2015; 4(4.000): 2884-9