Inverting the model of genomics data sharing with the NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space

The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL; https://anvilproject.org) was developed to address a widespread community need for a unified computing environment for genomics data storage, management, and analysis. In this perspective, we present AnVIL, describe its ecosystem and interoperability with other platforms, and highlight how this platform and associated initiatives contribute to improved genomic data sharing efforts. The AnVIL is a federated cloud platform designed to manage and store genomics and related data, enable population-scale analysis, and facilitate collaboration through the sharing of data, code, and analysis results. By inverting the traditional model of data sharing, the AnVIL eliminates the need for data movement while also adding security measures for active threat detection and monitoring and provides scalable, shared computing resources for any researcher. We describe the core data management and analysis components of the AnVIL, which currently consists of Terra, Gen3, Galaxy, RStudio/Bioconductor, Dockstore, and Jupyter, and describe several flagship genomics datasets available within the AnVIL. We continue to extend and innovate the AnVIL ecosystem by implementing new capabilities, including mechanisms for interoperability and responsible data sharing, while streamlining access management. The AnVIL opens many new opportunities for analysis, collaboration, and data sharing that are needed to drive research and to make discoveries through the joint analysis of hundreds of thousands to millions of genomes along with associated clinical and molecular data types

Universal Hashing for Ultra-Low-Power Cryptographic Hardware Applications

Message Authentication Codes (MACs) are valuable tools for ensuring the integrity of messages. MACs may be built around a keyed hash function. Our main motivation was to prove that universal hash functions can be employed as underlying primitives of MACs in order to provide provable security in ultra-low-power applications such as the next generation self-powered sensor networks. The idea of using a universal hash function (NH) was explored in the construction of UMAC. This work presents three variations on NH, namely PH, PR and WH. The first hash function we propose, PH, produces a hash of length 2w and is shown to be 2^(-w)-almost universal. The other two hash functions, i.e. PR and WH, reach optimality and are proven to be universal hash functions with half the hash length of w. In addition, these schemes are simple enough to allow for efficient constructions. To the best of our knowledge the proposed hash functions are the first ones specifically designed for low-power hardware implementations. We achieve drastic power savings of up to 59% and speedup of up to 7.4 times over NH. Note that the speed improvement and the power reduction are accomplished simultaneously. Moreover, we show how the technique of multi- hashing and the Toeplitz approach can be combined to reduce the power and energy consumption even further while maintaining the same security level with a very slight increase in the amount of key material. At low frequencies the power and energy reductions are achieved simultaneously while keeping the hashing time constant. We develope formulae for estimation of leakage and dynamic power consumptions as well as energy consumption based on the frequency and the Toeplitz parameter t. We introduce a powerful method for scaling WH according to specific energy and power consumption requirements. This enables us to optimize the hash function implementation for use in ultra-low-power applications such as ""Smart Dust"" motes, RFIDs, and Piconet nodes. Our simulation results indicate that the implementation of WH-16 consumes only 2.95 ìW 500 kHz. It can therefore be integrated into a self- powered device. By virtue of their security and implementation features mentioned above, we believe that the proposed universal hash functions fill an important gap in cryptographic hardware applications

TURKISH ATYPICAL HEMOLYTIC UREMIC SYNDROME REGISTRY: ECULIZUMAB TREATMENT IN AHUS PATIENTS

WOS: 000443998400089

Identification and Properties of Isolated Field Elliptical Galaxies from CFHTLS-W1

We present a catalogue of isolated field elliptical (IfE) galaxies drawn from the W1 field of the Canada-France-Hawaii Telescope Legacy Survey (CFHTLS). 228 IfEs were identified from a flux-limited (r<21.8) galaxy catalogue which corresponds to a density of 3 IfE/sq.deg. For comparison we consider a sample of elliptical galaxies living in dense environments, based on identification of the brightest cluster galaxies (BGCs) in the same survey. Using the same dataset for the comparison sample ensures a uniform selection, including in the redshift range as IfEs (i.e. 0.1 < z < 0.9). A comparison of elliptical galaxies in different environments reveals that IfEs and BCGs have similar behaviours in their colours, star formation activities, and scaling relations of mass-size and size-luminosity. IfEs and BCGs have similar slopes in the scaling relations with respect to cluster ellipticals within the $-24 \leq M_{r} \leq -22$ magnitude and $10.2< \textrm{log}( \textrm M_{*}/ \textrm M_\odot)\leq12.0$ mass ranges. Three IfEs identified in this study can be associated with fossil groups found in the same survey area which gives clues for future studies.Comment: 23 pages, 18 figures, 10 tables, accepted for publication in PAS

Are isolated anti-HBc blood donors in high risk group? The detection of HBV DNA in isolated anti-HBc cases with nucleic acid amplification test (NAT) based on transcription-mediated amplification (TMA) and HBV discrimination

Aim: Hepatitis B virus (HBV) can be transmitted by blood transfusions even so using serological tests having high sensitivity and specificity. We aimed to detect HBV DNA in isolated Anti-HBc donors and show if they have transfusion risk or not

The Effect of Reduction Mammaplasty on the Vertebral Column: A Radiologic Study

Some studies emphasized that anatomic mechanisms of vertebral aberrations could be associated with large breasts. The effect of mammaplasty operation on the vertebral column and body posture seems to be beneficial; in this trial, it was planned to investigate the objective radiologic effect of reduction mammaplasty on the posture of the vertebral column in a group of patients operated due to the large breasts. Thirty-four white women with large breasts were enrolled in this study. The patients were divided into three groups according to their breast cup sizes. Anteroposterior and lateral radiographs of the lumbosacral and thoracic spine were taken at baseline preoperatively, and the same radiographic images were taken in an average of 12 months later than the reduction mammaplasty operation. All were evaluated and compared for thoracic kyphosis angle and lumbar lordosis angle both preoperatively and postoperatively. The mean thoracic kyphosis angle was 40,53 preoperatively and 39,38 postoperatively. However, there was no statistically significant difference between the preoperative and postoperative measurements in all groups (P>0,05). The mean lumbar lordosis angle was 54,71 preoperatively and 53,18 postoperatively. Regarding the preoperative and postoperative measurements of lumbar lordosis angles, no statistically significant difference was found between the groups (P>0,05). Although breast size may be an important factor that affects body posture, reduction mammaplasty operations have little or no radiologic effect on the vertebral column

Can the nucleic acid amplification test (NAT) be an alternative to the serologic tests? A prospective study, the results of 18,200 blood donors from the Turkish Red Crescent

Aim: Serologic tests having high sensitivity and specificity are used in order to prevent contamination with infectious agents from blood and blood products for transfusion safety. The present serologic tests have problems such as low sensitivity and weak detection capacity of infectious agents in the "window period". We aimed to test the use of NAT (Nucleic Acid Amplification Test) in routine blood screening in the Blood Bank