Lepton flavor violation via four-Fermi contact interactions at the International Linear Collider

Lepton flavor violating (LFV) process $e^+ e^- \to e^+ \tau^-$ induced by the four-Fermi contact interactions at the International Linear Collider (ILC) is studied. Taking account of the event selection conditions, it is shown that the ILC is sensitive to smaller LFV couplings as compared to the measurement of $\tau\to 3e$ process at the B-factory experiment. The upper bounds on some of the LFV couplings are improved by several factors using polarized $e^-/e^+$ beams at $\sqrt{s}=250~\mathrm{GeV}$ and by an order of magnitude at $\sqrt{s}=1~\mathrm{TeV}$.Comment: 14 pages, 6 figures. Version to appear in Phys.Lett.

Insight into single cell cloning in serum-free media

Chinese hamster ovary (CHO) cells have been used as host cells for the manufacturing of therapeutic recombinant proteins over the past decade. It is thought that the development of high performance cell lines, which satisfy both productivity and regulatory expectations, is one of the key success drivers to establish good manufacturing processes. The cell line for the clinical and commercial productions should be derived from a single progenitor or clone, and so the single cell cloning is an essential step during the cell line development. Recently serum-free media have been widely applied for this step. But under such conditions, the cloning efficiency varies significantly among the clones. This might be because the serum-free conditions can be stressful for the CHO cells exposed to such an unexpected cloning process. In this study, we performed re-cloning from two pre-cloned cell lines to evaluate the impact of serum-free cloning on the resulting cell line characteristics; various parameters such as cell growth, productivity, fed-batch culture performance, product quality and cell stability were evaluated. As a result, most of the clones showed exactly the same performance before and after the cloning process, but some clones did not. The detail of these results will be presented and also the proper evaluation to be needed during cell line development, especially after the single cell isolation, will be discusse

Physiological variation among Tricholoma matsutake isolates generated from basidiospores obtained from one basidioma

ArticleMycoscience. 60(2): 102-109. (2019)journal articl

Sibling spore isolates of Tricholoma matsutake vary significantly in their ectomycorrhizal colonization abilities on pine hosts in vitro and form multiple intimate associations in single ectomycorrhizal roots

ArticleFungal Ecology. 43: 100874. (2020)journal articl

Attitudes and behaviors relating to theme parks (2) : the psychological functions of unreality feelings caused by Tokyo Disneyland.

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Colors of a Second Earth II: Effects of Clouds on Photometric Characterization of Earth-like Exoplanets

As a test-bed for future investigations of directly imaged terrestrial exoplanets, we present the recovery of the surface components of the Earth from multi-band diurnal light curves obtained with the EPOXI spacecraft. We find that the presence and longitudinal distribution of ocean, soil and vegetation are reasonably well reproduced by fitting the observed color variations with a simplified model composed of a priori known albedo spectra of ocean, soil, vegetation, snow and clouds. The effect of atmosphere, including clouds, on light scattered from surface components is modeled using a radiative transfer code. The required noise levels for future observations of exoplanets are also determined. Our model-dependent approach allows us to infer the presence of major elements of the planet (in the case of the Earth, clouds and ocean) with observations having S/N $\gtrsim 10$ in most cases and with high confidence if S/N $\gtrsim 20$. In addition, S/N $\gtrsim 100$ enables us to detect the presence of components other than ocean and clouds in a fairly model-independent way. Degradation of our inversion procedure produced by cloud cover is also quantified. While cloud cover significantly dilutes the magnitude of color variations compared to the cloudless case, the pattern of color changes remains. Therefore, the possibility of investigating surface features through light curve fitting remains even for exoplanets with cloud cover similar to the Earth's.Comment: 33 pages, 16 figures, accepted for publication in ApJ (discussion, references, and description of data reduction added, typo fixed

Integrated analysis of the oral and intestinal microbiome and metabolome of elderly people with more than 26 original teeth: a pilot study

Elderly subjects with more than 20 natural teeth have a higher healthy life expectancy than those with few or no teeth. The oral microbiome and its metabolome are associated with oral health, and they are also associated with systemic health via the oral-gut axis. Here, we analyzed the oral and gut microbiome and metabolome profiles of elderly subjects with more than 26 natural teeth. Salivary samples collected as mouth-rinsed water and fecal samples were obtained from 22 healthy individuals, 10 elderly individuals with more than 26 natural teeth and 24 subjects with periodontal disease. The oral microbiome and metabolome profiles of elderly individuals resembled those of subjects with periodontal disease, with the metabolome showing a more substantial differential abundance of components. Despite the distinct oral metabolome profiles, there was no differential abundance of components in the gut microbiome and metabolomes, except for enrichment of short-chain fatty acids in elderly subjects. Finally, to investigate the relationship between the oral and gut microbiome and metabolome, we analyzed bacterial coexistence in the oral cavity and gut and analyzed the correlation of metabolite levels between the oral cavity and gut. However, there were few associations between oral and gut for bacteria and metabolites in either elderly or healthy subjects. Overall, these results indicate distinct oral microbiome and metabolome profiles, as well as the lack of an oral-gut axis in elderly subjects with a high number of natural teeth