The influence of scope, depth, and orientation of external technology sources on the innovative performance of Chinese firms

It is commonly accepted nowadays that external knowledge sources are important for firms’ innovative performance. However, it is still not clear, what dimensions of firms’ external knowledge search strategy are crucial in determining their innovation success and whether these search strategies are contingent on different innovation modes. In this study, we analyze how the innovative performance is affected by the scope, depth, and orientation of firms’ external search strategies. We apply this analysis to firms using STI (science, technology and innovation) and DUI (doing, using and interacting) innovation modes. Based on a survey among firms in China, we find that greater scope and depth of openness for both innovation modes improves innovative performance indicating that open innovation is also relevant beyond science and technology based innovation. Furthermore, we find that decreasing returns in external search strategies, suggested by Laursen and Salter (2006), are not always present and are contingent on the innovation modes. Next, we find that the type of external partners (we label it “orientation of openness”) is crucial in explaining innovative performance and that firms using DUI or STI innovation modes have different sets of relevant innovation partners. This shows that the orientation of openness is an important dimension – in addition to the scope and depth of openness. As respondents are located in China, this study provides evidence that open innovation is also relevant in developing countries

The influence of scope, depth, and orientation of external technology sources on the innovative performance of Chinese firms

It is commonly accepted nowadays that external knowledge sources are important for firms’ innovative performance. However, it is still not clear, what dimensions of firms’ external knowledge search strategy are crucial in determining their innovation success and whether these search strategies are contingent on different innovation modes. In this study, we analyze how the innovative performance is affected by the scope, depth, and orientation of firms’ external search strategies. We apply this analysis to firms using STI (science, technology and innovation) and DUI (doing, using and interacting) innovation modes. Based on a survey among firms in China, we find that greater scope and depth of openness for both innovation modes improves innovative performance indicating that open innovation is also relevant beyond science and technology based innovation. Furthermore, we find that decreasing returns in external search strategies, suggested by Laursen and Salter (2006), are not always present and are contingent on the innovation modes. Next, we find that the type of external partners (we label it “orientation of openness”) is crucial in explaining innovative performance and that firms using DUI or STI innovation modes have different sets of relevant innovation partners. This shows that the orientation of openness is an important dimension – in addition to the scope and depth of openness. As respondents are located in China, this study provides evidence that open innovation is also relevant in developing countries

RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients

RB1-inducible coiled-coil 1 (RB1CC1) plays a significant role in the enhancement of the retinoblastoma tumor suppressor (RB1) pathway and is involved in breast cancer development. However, RB1CC1's role in clinical progression of breast cancer has not yet been evaluated, so, as a first step, it is necessary to establish its usefulness as a tool to evaluate breast cancer patients. In this report, we have analyzed the correlation between abnormalities in the RB1CC1 pathway and long-term prognosis, because disease-specific death in later periods (>5 years) of the disease is a serious problem in breast cancer. Breast cancer tissues from a large cohort in Japan were evaluated by conventional immunohistochemical methods for the presence of the molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and other well-known prognostic markers for breast cancer, such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The correlation between the immunohistochemical results and clinical outcomes of 323 breast cancer patients was analyzed using a Kaplan-Meier log-rank test and a multivariate Cox proportional hazards regression analysis. Absence of nuclear RB1CC1 expression was associated with the worst prognosis (Log-rank test, Chi-Square value = 17.462, p<0.0001). Dysfunction of either one of RB1CC1, RB1, or p53 was associated with the highest risk for cancer-specific death, especially related to survival lasting more than 5 years (multivariate Cox proportional hazard ratio = 3.951, 95% Confidence Interval = 1.566–9.967, p = 0.0036). Our present data demonstrate that the combined evaluation of RB1CC1, RB1 and p53 by conventional immunohistochemical analysis provides an accurate prediction of the long-term prognoses of breast cancer patients, which can be carried out as a routine clinical examination

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Financing selection method in discipline evaluation using a weighted induced model

The selection of a suitable fi nancing alternative involves multifarious attributes that should be assessed to provide a basis foundation for decision-making. As an effective generation of intuitionistic fuzzy set and linguistic term, the intuitionistic linguistic set (ILS) has greater power for processing uncertain information during decision-making process. Keep this feature in mind, the main purpose of this paper is to investigate a weighted induced aggregation approach for decisionmaking problem concerning fi nancing selection with complex uncertainty in term of intuitionistic linguistic (IL) information. For this, a new intuitionistic linguistic aggregation operator based on the weighted induced approach, namely the IL weighted induced ordered average-weighted averaging (ILWIOWAWA) operator, is proposed to integrate intuitionistic linguistic information. The special advantage of this operator is that it can integrate the subjective information with the particular attitudinal characters in form of order-induced variables in the same expression during information fusion. Moreover, it is able to deal with uncertain information represented by intuitionistic linguistic set very effectively. Some of its properties and particular cases are mathematically explored. We have proved that it has the properties of monotonicity, boundedness, idempotency, nonnegativity and refl exivity. A further extension of the proposed operator is also represented in term of quasiarithmetic means, then we get the quasi-arithmetic ILWIOWAWA (QILWIOWAWA) operator, which encompasses a very broad class of IL aggregation operators. In addition, based on the developed operator, a procedure for multiple attribute group decision-making (MAGDM) problems has been discussed. Finally, a numerical application related to the discipline evaluation in university is used to show the validity and practicability of the proposed method

Early child development in low- and middle-income countries: Is it what mothers have or what they do that makes a difference to child outcomes?

Child developmental theories and a large body of literature underscore the importance of both home and preschool influences on early childhood outcomes. We leveraged data from UNICEF'S Multiple Indicator Cluster Surveys, a nationally representative international household survey that has collected cohort comparable information on children's early development in over 118 low- and middle-income countries since 1995. We focused on data from 216,052 3- to 4-year-olds (106,037 girls) from 28 countries that had undertaken at least two surveys from 2010 to 2018. We considered the impact of maternal education and household wealth (what mothers/caregivers have) on home learning activities and sending children to early childhood programs (what mothers/caregivers do), on early child development. Our results indicated that maternal education, household wealth, home learning activities, participation in early childhood education (ECE) and scores on the early childhood development index (ECDI) generally increased over time and were significantly related to each other. Multilevel structural equation modeling revealed the mechanism through which maternal education and household wealth were associated with child outcomes. More wealthy and more educated mothers were more likely to send their child to an ECE program, which was in turn, associated with a higher ECDI score. Caregiver-reported participation in ECE had a large effect on the ECDI score while maternal education had a small effect on it. In comparison the effects of the home learning environment were much smaller. Taken together, findings suggest that education and wealth (what parents have) influence what they do (providing opportunities for learning), which in turn influences early child development. Furthermore, exposure to ECE services was particularly important for children's development. We conclude by discussing the policy implications of our findings and providing suggestions for future research

Diagnosis of Xinmo (China) Landslide Based on Interferometric Synthetic Aperture Radar Observation and Modeling

The Xinmo landslide occurred on 24 June 2017 and caused huge casualties and property losses. As characteristics of spatiotemporal pre-collapse deformation are a prerequisite for further understanding the collapse mechanism, in this study we applied the interferometric synthetic aperture radar (InSAR) technique to recover the pre-collapse deformation, which was further modeled to reveal the mechanism of the Xinmo landslide. Archived SAR data, including 44 Sentinel-1 A/B data and 20 Envisat/ASAR data, were used to acquire the pre-collapse deformation of the Xinmo landslide. Our results indicated that the deformation of the source area occurred as early as 10 years before the landslide collapsed. The deformation rate of source area accelerated about a month before the collapse, and the deformation rate in the week before the collapse reached 40 times the average before the acceleration. Furthermore, the pre-collapse deformation was modeled with a distributed set of rectangular dislocation sources. The characteristics of the pre-collapse movement of the slip surface were acquired, which further confirmed that a locked section formed at the bottom of the slope. In addition, the spatial-temporal characteristics of the deformation was found to have changed significantly with the development of the landslide. We suggested that this phenomenon indicated the expansion of the slip surface and cracks of the landslide. Due to the expansion of the slip surface, the locked section became a key area that held the stability of the slope. The locked section sheared at the last stage of the development, which triggered the final run-out. Our study has provided new insights into the mechanism of the Xinmo landslide

Copper-Catalyzed Aerobic Oxidative Intramolecular C-H Amination Leading to Imidazobenzimidazole Derivatives

National Natural Science Foundation of China [20972083, 21172128]; Ministry of Science and Technology of China [2012CB722600]A highly efficient copper-catalyzed aerobic oxidative intramolecular C-H amination has been developed using substituted 2-(1H-imidazol-1-yl)-N-alkylbenzenamines as the starting materials, and the corresponding imidazobenzimidazole derivatives were obtained in excellent yields. This is an economical and practical method for the construction of N-heterocycles