A corpus-based comparative study on George Orwell’s 1984 Chinese translation strategies.

This paper adopts a corpus-based approach to compare the translation strategies employed by Dong Leshan (1979/1998) and Lau Shiuming (1984/2011) in their translation of George Orwell’s Nineteen Eighty-Four. The linguistic features are first retrieved from our translation corpora using the corpus tools, ICTCLAS 5.0 and AntConc 3.4.3, and then compared and analyzed quantitatively. Statistics show that the two translators differ significantly in their employment of four types of function word: modal particles, conjunctions, prepositions, and numerals. Equivalent textual examples from the two translations are extracted and analyzed qualitatively, to illustrate how the use of these function words embodies different translation strategies. The analysis specifically focuses on the comparison between hypotactic and paratactic features in the English-Chinese translations. The findings in this study indicate that Dong shows the tendency of aiming to achieve formal equivalence to the English source language in his Chinese translation. By contrast, Lau tends to provide a translation that conforms to the customary convention of the Chinese target language by adding modal particles and adversative conjunctions as well as adjusting the sentence order, to make the implied meaning in a sentence explicitly for the target reader

Method of fabricating thallium-containing ceramic superconductors

An improved technique for the fabrication of thallium-based superconducting oxides, and particularly Tl:Ba:Ca:Cu:O 2223 oxides, is described which allows production of very pure superconductors (\u3e95% 2223 phase) having excellent structural characteristics. The method of the invention involves first forming a self-sustaining body of starting oxides and subjecting this body to a sintering technique wherein the temperature of the body is gradually raised to a maximum level of about 850°-930° C, followed by maintaining the body at this temperature for a period of about 48 hours. The body is then slowly cooled to avoid distortion and loss of superconducting character. Most preferably, the sintering is a two-stage operation, where the body is first heated at a relatively low rate (e.g., 1°-10° C/min.) to a temperature of about 650°-750° C, followed by faster heating at a higher rate to achieve the maximum sintering temperature. Cooling is likewise staged, involving slow cooling at a rate of about 0.1°-5° C/min. until a temperature of about 600°-650° C is reached. The body is maintained at this temperature for about 5-20 hours. Final cooling is allowed to occur naturally down to ambient temperature

The Effects of Shape-taste Congruence on Product Evaluations

The background design of a product presented online is important to attract consumers’ attention and further help them make proper judgments about the product. Although many studies have investigated factors of advertising background design, few focus on the effect of shape feature in the background on product evaluations. The present research investigates the influence of congruency between the shape in the background design and product taste perception on consumer product evaluations by using a pretest and three experiments. The results show that shape-taste congruency intensifies product evaluations with an increase evaluation of sweet-taste products and a decreases evaluation of sour-taste products (study1a & 1b). We explain the effect of shape-taste congruency through positive affect (study 2). In addition, an individual’s design sensitivity moderates the effect of shape-taste congruency on product evaluations, which means the effect of shape-taste congruency will disappear for people with low design sensitivity (study 3). The research provides important implications for online retailers in product display design

Spatial and Temporal Characteristics of Snow Cover in the Tizinafu Watershed of the Western Kunlun Mountains

The Tizinafu watershed has a complex mountainous terrain in the western Kunlun Mountains; little study has been done on the spatial and temporal characteristics of snow cover in the region. Daily snow cover data of 10 hydrological years (October 2002 to September 2012) in the watershed were generated by combining MODIS Terra (MOD10A1) and Aqua (MYD10A1) snow cover products and employing a nine-day temporal filter for cloud reduction. The accuracy and window size of the temporal filter were assessed using a simulation approach. Spatial and temporal characteristics of snow cover in the watershed were then analyzed. Our results showed that snow generally starts melting in March and reaches the minimum in early August in the watershed. Snow cover percentages (SCPs) in all five elevation zones increase consistently with the rise of elevation. Slope doesn’t play a major role in snow cover distribution when it exceeds 10°. The largest SCP difference is between the south and the other aspects and occurs between mid-October and mid-November with decreasing SCP, indicating direct solar radiation may cause the reduction of snow cover. While both the mean snow cover durations (SCDs) of the hydrological years and of the snowmelt seasons share a similar spatial pattern to the topography of the watershed, the coefficient of variation of the SCDs exhibits an opposite spatial distribution. There is a significant correlation between annual mean SCP and annual total stream flow, indicating that snowmelt is a major source of stream runoff that might be predictable with SCP

3-Hydroxyisobutyryl-CoA hydrolase involved in isoleucine catabolism regulates triacylglycerol accumulation in Phaeodactylum tricornutum

Since methylmalonyl-CoA epimerase appears to be absent in the majority of photosynthetic organisms, including diatoms, (S)-methylmalonyl-CoA, the intermediate of isoleucine (Ile) catabolism, cannot be metabolized to (R)methylmalonyl-CoA then to succinyl-CoA. In this study, propionyl-CoA carboxylase (PCC) RNAi silenced strains and 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) overexpression strains were constructed to elucidate the Ile degradation pathway and its influence on lipid accumulation in Phaeodactylum tricornutum based on growth, neutral lipid content and metabolite profile analysis. Knockdown of PCC disturbed the metabolism of Ile through propionyl-CoA to methylmalonyl-CoA, as illustrated by much higher Ile content at day 6. However, Ile decreased to comparable levels to the wild-type at day 10. PCC silencing redirected propionyl-CoA to acetyl-CoA via a modified beta-oxidation pathway, and transcript levels for some branched-chain amino acid (BCAA) degradation-related genes, especially HIBCH, significantly upregulated in the PCC mutant, which enhanced the BCAA degradations and thus resulted in higher triacylglycerol (TAG) content. Overexpression of HIBCH accelerates Ile degradation and results in a lowered Ile content in the overexpression strains, thus enhancing carbon skeletons to the tricarboxylic acid cycle and giving rise to increasing TAG accumulation. Our study provides a good strategy to obtain high-lipid-yield transgenic diatoms by modifying the propionyl-CoA metabolism. This article is part of the themed issue &#39;The peculiar carbon metabolism in diatoms&#39;.</p

Extraction and Purification of a Lectin from Red Kidney Bean and Preliminary Immune Function Studies of the Lectin and Four Chinese Herbal Polysaccharides

Reversed micelles were used to extract lectin from red kidney beans and factors affecting reverse micellar systems (pH value, ionic strength and extraction time) were studied. The optimal conditions were extraction at pH 4–6, back extraction at pH 9–11, ion strength at 0.15 M NaCl, extraction for 4–6 minutes and back extraction for 8 minutes. The reverse micellar system was compared with traditional extraction methods and demonstrated to be a time-saving method for the extraction of red kidney bean lectin. Mitogenic activity of the lectin was reasonably good compared with commercial phytohemagglutinin (extracted from Phaseolus vulgaris) Mitogenic properties of the lectin were enhanced when four Chinese herbal polysaccharides were applied concurrently, among which 50 μg/mL Astragalus mongholicus polysaccharides (APS) with 12.5 μg/mL red kidney bean lectin yielded the highest mitogenic activity and 100 mg/kg/bw APS with 12.5 mg/kg/bw red kidney bean lectin elevated mouse nonspecific immunity

TRIM 16 gene expression regulates the growth and metastasis of human esophageal cancer

Purpose: To investigate the effect of tripartite membrane protein&nbsp; TRIM) 16 gene silencing on human esophageal cancer (KYSE-270) cell proliferation, invasion and metastasis.Methods: Short interfering RNA (siRNA) TRIM 16 silencing fragment was transfected into KYSE-270 cells. Transfection efficiency was determined using real-time quantitative polymerase chain reaction (qRT-PCR). Cell proliferation, invasiveness and migration were measured by 3-(4,5-dimethylthiazol2-yl)- 2,5-diphenyl tetrazolium bromide (MTT) assay, Transwell invasion assay, and scratch test, respectively. Protein expressions of bax and bcl-2 were assayed using Western blotting.Results: The gene expression of TRIM 16 was significantly upregulated in esophageal cancer cells, relative to normal human esophageal cells, but was downregulated after gene silencing. Moreover, the silencing of TRIM 16 gene led to significant reductions in KYSE-270 cell viability, migration and invasiveness, but significantly increased KYSE270 cell apoptosis (p &lt; 0.05). The silencing of TRIM 16 gene also significantly upregulated bax protein expression, while downregulating the expression of bcl-2 protein (p &lt; 0.05).Conclusion: These results suggest that TRIM 16 gene silencing inhibits KYSE-270 cell proliferation, invasion and metastasis, and thus provide a basis for its development as a therapeutic approach for the management of esophageal cancer. Keywords: Apoptosis, Cell invasion, Esophageal cancer, Gene silencing, Metastasi

Prevalence of hyperglycemia among adults with newly diagnosed HIV/AIDS in China

BACKGROUND: The prevalence of hyperglycemia among HIV-infected persons who are not receiving antiretroviral therapy is unknown. We conducted a cross-sectional survey to estimate the prevalence of hyperglycemia among Chinese adults with newly diagnosed HIV/AIDS. METHODS: Two thousand and six newly diagnosed HIV/AIDS patients from 10 provinces and municipalities in China were selected during 2009 to 2010. After an overnight fast, serum samples were collected to measure glucose concentrations. Demographics and medical histories were recorded. Factors associated with the presence of diabetes were analysed by logistic regression. RESULTS: Among the 2006 patients, 75.67% were male. Median age was 40 years (range: 18–86 years). 19.99% had hyperglycemia, 9.47% had impaired fasting glucose (IFG) and 10.52% had diabetes. The prevalences of hyperglycemia, of IFG and of diabetes were 21.54%, 10.28% and 11.27% among men and 15.16%, 6.97% and 8.20% among women, respectively. The prevalence of diabetes increased with increasing age (7.00%, 13.36% and 21.21% among patients who were 18–40, 40–60, and ≥60 years of age respectively) and with decreasing CD4 count (6.74%, 8.45%, 9.69%, and 12.66% among patients with CD4 count of ≥350, 200–350, 50–200, and < 50/mm(3) respectively). The prevalence of diabetes was higher among ethnic minority patients than among the Han patients (14.37% versus 9.24%). The logistic analysis showed that older age, lower CD4 count and minority ethnicity were significantly associated with an increased risk of diabetes. CONCLUSIONS: Hyperglycemia is highly prevalent among Chinese adults with newly diagnosed HIV/AIDS. Older age, lower CD4 count and minority ethnicity are associated with increased risk of diabetes. All newly diagnosed HIV/AIDS individuals should be routinely evaluated for hyperglycemia

Hybrid Random Regret Minimization and Random Utility Maximization in the Context of Schedule-Based Urban Rail Transit Assignment

Route choice is one of the most critical passenger behaviors in public transit research. The utility maximization theory is generally used to model passengers’ route choice behavior in a public transit network in previous research. However, researchers have found that passenger behavior is far more complicated than a single utility maximization assumption. Some passengers tend to maximize their utility while others would minimize their regrets. In this paper, a schedule-based transit assignment model based on the hybrid of utility maximization and regret minimization is proposed to study the passenger route choice behavior in an urban rail transit network. Firstly, based on the smart card data, the space-time expanded network in an urban rail transit was constructed. Then, it adapts the utility maximization (RUM) and the regret minimization theory (RRM) to analyze and model the passenger route choice behavior independently. The utility values and the regret values are calculated with the utility and the regret functions. A transit assignment model is established based on a hybrid of the random utility maximization and the random regret minimization (RURM) with two kinds of hybrid rules, namely, attribute level hybrid and decision level hybrid. The models are solved by the method of successive algorithm. Finally, the hybrid assignment models are applied to Beijing urban rail transit network for validation. The result shows that RRM and RUM make no significant difference for OD pairs with only two alternative routes. For those with more than two alternative routes, the performance of RRM and RUM is different. RRM is slightly better than RUM in some of the OD pairs, while for the other OD pairs, the results are opposite. Moreover, it shows that the crowd would only influence the regret value of OD pair with more commuters. We conclude that compared with RUM and RRM, the hybrid model RURM is more general. Document type: Articl

CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation

Antigen-induced immune suppression, like T cell activation, requires antigen-presenting cells (APCs); however, the role of APCs in mediating these opposing effects is not well understood, especially in vivo. We report that genetic inactivation of CD11b, which is a CD18 subfamily of integrin receptors that is highly expressed on APCs, abolishes orally induced peripheral immune tolerance (oral tolerance) without compromising APC maturation or antigen-specific immune activation. The defective oral tolerance in CD11b−/− mice can be restored by adoptive transfer of wild-type APCs. CD11b deficiency leads to enhanced interleukin (IL) 6 production by APCs, which subsequently promotes preferential differentiation of naive T cells to T helper 17 (Th17) cells, which are a T cell lineage characterized by their production of IL-17. Consequently, antigen feeding and immunization of CD11b−/− mice results in significant production of IL-17 within the draining lymph nodes that interferes with the establishment of oral tolerance. Together, we conclude that CD11b facilitates oral tolerance by suppressing Th17 immune differentiation