catena-Poly[[dimethyl­tin(IV)]-μ-cis-cyclo­hexane-1,2-dicarboxyl­ato]

The title complex, [Sn(CH3)2(C8H10O4)]n, was synthesized from cis-cyclo­hexane-1,2-dicarboxylic acid and dimethyl­tin dichloride. The complex has a bridging bis-bidentate carboxyl­ate group resulting in a zig-zag chain structure parallel to [001]. The Sn atom is six-coordinated and displays a distorted octa­hedral geometry

Neighbourhood satisfaction in rural resettlement residential communities: the case of Suqian, China

Against the background of large-scale urbanisation and rural land expropriation, rural resettlement residential housing has been built to accommodate local rural residents in the peripheral areas of China. To explore the context-specific policy implications for improving neighbourhood satisfaction (NS) of residents in rural resettlement residential communities (RRRCs), this paper examines the determinants of NS, and their spatial effects, in rural resettlement residential neighbourhoods using Suqian, in Jiangsu Province, as a case study. This study contributes to the current literature in two ways: it constitutes the first attempt to examine NS among RRRCs; second, our spatial model helps to gain further understanding of horizontal and vertical spatial dependence effects. Our results indicate that income, gender, age, family structure, number of years living in a community, transport and architectural age all have significant effects on NS in RRRCs

The predictive value of T-cell chimerism for disease relapse after allogeneic hematopoietic stem cell transplantation

IntroductionChimerism is closely correlated with disease relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, chimerism rate is dynamic changes, and the sensitivity of different chimerism requires further research.MethodsTo investigate the predictive value of distinct chimerism for relapse, we measured bone marrow (BM), peripheral blood (PB), and T-cell (isolated from BM) chimerism in 178 patients after allo-HSCT.ResultsReceiver operating characteristic (ROC) curve showed that T-cell chimerism was more suitable to predict relapse after allo-HSCT compared with PB and BM chimerism. The cutoff value of T-cell chimerism for predicting relapse was 99.45%. Leukemia and myelodysplastic syndrome (MDS) relapse patients’ T-cell chimerism was a gradual decline from 2 months to 9 months after allo-HSCT. Higher risk of relapse and death within 1 year after allo-HSCT. The T-cell chimerism rates in remission and relapse patients were 99.43% and 94.28% at 3 months after allo-HSCT (P = 0.009), 99.31% and 95.27% at 6 months after allo-HSCT (P = 0.013), and 99.26% and 91.32% at 9 months after allo-HSCT (P = 0.024), respectively. There was a significant difference (P = 0.036) for T-cell chimerism between early relapse (relapse within 9 months after allo-HSCT) and late relapse (relapse after 9 months after allo-HSCT) at 2 months after allo-HSCT. Every 1% increase in T-cell chimerism, the hazard ratio for disease relapse was 0.967 (95% CI: 0.948–0.987, P<0.001).DiscussionWe recommend constant monitoring T-cell chimerism at 2, 3, 6, and 9 months after allo-HSCT to predict relapse

RETRACTED: MiR-22 Inhibition Alleviates Cardiac Dysfunction in Doxorubicin-Induced Cardiomyopathy by Targeting the sirt1/PGC-1α Pathway

Doxorubicin (DOX) cardiotoxicity is a life-threatening side effect that leads to a poor prognosis in patients receiving chemotherapy. We investigated the role of miR-22 in doxorubicin-induced cardiomyopathy and the underlying mechanism in vivo and in vitro. Specifically, we designed loss-of-function and gain-of-function experiments to identify the role of miR-22 in doxorubicin-induced cardiomyopathy. Our data suggested that inhibiting miR-22 alleviated cardiac fibrosis and cardiac dysfunction induced by doxorubicin. In addition, inhibiting miR-22 mitigated mitochondrial dysfunction through the sirt1/PGC-1α pathway. Knocking out miR-22 enhanced mitochondrial biogenesis, as evidenced by increased PGC-1α, TFAM, and NRF-1 expression in vivo. Furthermore, knocking out miR-22 rescued mitophagy, which was confirmed by increased expression of PINK1 and parkin and by the colocalization of LC3 and mitochondria. These protective effects were abolished by overexpressing miR-22. In conclusion, miR-22 may represent a new target to alleviate cardiac dysfunction in doxorubicin-induced cardiomyopathy and improve prognosis in patients receiving chemotherapy

Towards sustainability: An assessment of an urbanisation bubble in China using a hierarchical - stochastic multicriteria acceptability analysis - Choquet integral method

Urbanisation bubbles have become an increasingly serious problem. Attention has been paid to the speed of urbanisation; however, the issue of quality has been neglected, particularly in the case of China. Therefore, the aim of this research is to evaluate China’s urbanisation bubbles by employing a hierarchical - stochastic multicriteria acceptability analysis (SMAA) - Choquet integral method. In order to highlight regional disparities, we measure the urbanisation bubbles at a provincial level. Our study aggregates the urbanisation bubble indices using the Choquet integral preference model, and considers the interactions between various indicators. Furthermore, robust ordinal regression and SMAA are applied to resolve the robustness issues associated with the entire set of weights assigned to the urbanisation bubble composite indicator. In addition, by employing a multiple criteria hierarchy process, the study aggregates urbanisation bubble indices not only at the comprehensive level, but also at the intermediate levels of the hierarchy. Our findings suggest that the ranking of urbanisation bubbles is positively related to the level of regional development. This study contributes to the evaluation of regional urbanisation and sustainable development

Osteryoung square wave voltammetric determination of lactose in food samples by a derivative procedure

A method for determination of lactose in food samples by Osteryoung square wave voltammetry (OSWV) was developed. It was based on the nucleophilic addition reaction between lactose and aqua ammonia. The carbonyl group of lactose can be changed into imido group, and this increases the electrochemical activity in reduction and the sensitivity. The optimal condition for the nucleophilic addition reaction was investigated and it was found that in NH4Cl–NH3 buffer of pH 10.1, the linear range between the peak current and the concentration of lactose was 0.6–8.4 mg L−1, and the detection limits was 0.44 mg L−1. The proposed method was applied to the determination of lactose in food samples and satisfactory results were obtained