3,480 research outputs found
1-{2-[(2-hydroxybenzylidene)-amino]-ethyl}-3-methyl-3H-imidazolium hexafluorophosphate
The title Schiff base compound, C13H16N3O+·PF6
−, was derived from the condensation of 2-hydroxybenaldehyde with the ionic liquid 1-(2-aminoethyl)-3-methylimidazolium hexafluorophosphate in an ethanol solution. The asymmetric unit comprises one cation and two PF6
− anions. The dihedral angle between the aromatic and imidazole rings is 15.2 (2)°. An intramolecular O—H⋯N hydrogen bond is found which generates an S(6) ring motif
On the Nonexistence of a Strong Minimal Pair
Two nonzero recursively enumerable (r.e.) degrees and
form a strong minimal pair if and for any
nonzero r.e. degree . We prove that there is no
strong minimal pair in the r.e. degrees. Our construction goes beyond the usual
-priority arguments and we give some evidence to show that it
needs -priority arguments
3,3′-Dibromo-5,5′-bis[(S)-l-menthyloxy]-4,4′-(hexane-1,6-diyldiimino)difuran-2(5H)-one
The title compound, C34H54Br2N2O6, was obtained by the Michael addition–elimination reaction of (5S)-5-(l-menthyloxy)-3,4-dibromofuran-2(5H)-one with 1,6-hexanediamine in the presence of triethylamine. The crystal structure contains two chiral five-membered furanone rings, in twist and envelope conformations, and two six-membered cyclohexane rings in chair conformations
Poly[[tetraaquadi-μ3-oxalato-μ2-oxalato-diprasedymium(III)] dihydrate]
In the title compound, {[Pr2(C2O4)3(H2O)4]·2H2O}n, the three-dimensional network structure has the PrIII ion coordinated by nine O atoms in a distorted tricapped trigonal-prismatic geometry. The coordinated and uncoordinated water molecules interact with the carboxylate O atoms to consolidate the network via O—H⋯O hydrogen bonds
8-(Carboxymethoxy)quinolinium nitrate monohydrate
In the title compound, C11H10NO3
+·NO3
−·H2O, the planar 8-carboxymethoxyquinolinium cation, the nitrate anion and the water molecule are dimerized by hydrogen bonds into square building-block units, and then further assembled into two-dimensional gently undulating supramolecular layers
Tetraspanins: Novel Molecular Regulators of Gastric Cancer
Gastric cancer is the fourth and fifth most common cancer worldwide in men and women, respectively. However, patients with an advanced stage of gastric cancer still have a poor prognosis and low overall survival rate. The tetraspanins belong to a protein superfamily with four hydrophobic transmembrane domains and 33 mammalian tetraspanins are ubiquitously distributed in various cells and tissues. They interact with other membrane proteins to form tetraspanin-enriched microdomains and serve a variety of functions including cell adhesion, invasion, motility, cell fusion, virus infection, and signal transduction. In this review, we summarize multiple utilities of tetraspanins in the progression of gastric cancer and the underlying molecular mechanisms. In general, the expression of TSPAN8, CD151, TSPAN1, and TSPAN4 is increased in gastric cancer tissues and enhance the proliferation and invasion of gastric cancer cells, while CD81, CD82, TSPAN5, TSPAN9, and TSPAN21 are downregulated and suppress gastric cancer cell growth. In terms of cell motility regulation, CD9, CD63 and CD82 are metastasis suppressors and the expression level is inversely associated with lymph node metastasis. We also review the clinicopathological significance of tetraspanins in gastric cancer including therapeutic targets, the development of drug resistance and prognosis prediction. Finally, we discuss the potential clinical value and current limitations of tetraspanins in gastric cancer treatments, and provide some guidance for future research
Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling.
BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury. However, whether Hsp70 interacts with p38 MAPK signaling is unclear. Therefore, this study investigated the regulation of p38 MAPK by Hsp70 in I/R-induced cardiac injury.MethodsNeonatal rat cardiomyocytes were subjected to oxygen-glucose deprivation for 6 h followed by 2 h reoxygenation (OGD/R), and rats underwent left anterior artery ligation for 30 min followed by 30 min of reperfusion. The p38 MAPK inhibitor (SB203580), Hsp70 inhibitor (Quercetin), and Hsp70 short hairpin RNA (shRNA) were used prior to OGD/R or I/R. Cell viability, lactate dehydrogenase (LDH) release, serum cardiac troponin I (cTnI), [Ca2+]i levels, cell apoptosis, myocardial infarct size, mRNA level of IL-1β and IL-6, and protein expression of Hsp70, phosphorylated p38 MAPK (p-p38 MAPK), sarcoplasmic/endoplasmic reticulum Ca2+-ATPase2 (SERCA2), phosphorylated signal transducer and activator of transcription3 (p-STAT3), and cleaved caspase3 were assessed.ResultsPretreatment with a p38 MAPK inhibitor, SB203580, significantly attenuated OGD/R-induced cell injury or I/R-induced myocardial injury, as evidenced by improved cell viability and lower LDH release, resulted in lower serum cTnI and myocardial infarct size, alleviation of [Ca2+]i overload and cell apoptosis, inhibition of IL-1β and IL-6, and modulation of protein expressions of p-p38 MAPK, SERCA2, p-STAT3, and cleaved-caspase3. Knockdown of Hsp70 by shRNA exacerbated OGD/R-induced cell injury, which was effectively abolished by SB203580. Moreover, inhibition of Hsp70 by quercetin enhanced I/R-induced myocardial injury, while SB203580 pretreatment reversed the harmful effects caused by quercetin.ConclusionsInhibition of Hsp70 aggravates [Ca2+]i overload, inflammation, and apoptosis through regulating p38 MAPK signaling during cardiac I/R injury, which may help provide novel insight into cardioprotective strategies
Isomorphic Cd(II)/Zn(II)-MOFs as Bifunctional Chemosensors for Anion (Cr2O72–) and Cation (Fe3+) detection in Aqueous Solution
Two isomorphic 3D MOFs [Cd(2-bpeb)(sdba)] (1) and [Zn(2-bpeb)(sdba)] derived from the π-conjugated pro-ligand 2-(4-((E)-2-(pyridine-2-yl)vinyl)styryl)pyridine (2-bpeb) and 4,4’-sulfonyldibenzoate (H2sdba) were synthesized and characterized. Complexes 1 and 2 exhibit striking fluorescence properties and can function as chemical sensors via rapid luminescence quenching in the presence of Fe3+and Cr2O72- in aqueous media with high sensitivity and selectivity
Field test of a practical secure communication network with decoy-state quantum cryptography
We present a secure network communication system that operated with
decoy-state quantum cryptography in a real-world application scenario. The full
key exchange and application protocols were performed in real time among three
nodes, in which two adjacent nodes were connected by approximate 20 km of
commercial telecom optical fiber. The generated quantum keys were immediately
employed and demonstrated for communication applications, including unbreakable
real-time voice telephone between any two of the three communication nodes, or
a broadcast from one node to the other two nodes by using one-time pad
encryption.Comment: 10 pages, 2 figures, 2 tables, typos correcte
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