A case of intraosseous spindle cell carcinoma of the mandible

Spindle cell carcinoma is a unique and rare biphasic tumor consisting of a squamous cell carcinoma component and a sarcomatoid component of spindle cells. We report a rare case of spindle cell carcinoma of the mandible that was considered an intraosseous carcinoma. The patient was a 67-year-old woman with a chief complaint of paresthesia of the left lower lip. There was no particular sign of the left mandibular gingiva. A panoramic radiograph showed a radiolucent area in the left premolar region of the mandible. Computed tomographic scans showed a ring-enhanced mass lesion in the same location. A biopsy was performed for a diagnosis of mandibular osteomyelitis. Because the diagnosis was granulation tissue, we performed curettage of the mandibular bone. However, the surgical specimen was histopathologically and immunohistochemically diagnosed as spindle cell carcinoma. We performed a segmental mandibulectomy with a safety margin. There has been no sign of local recurrence or metastasis during a follow-up period of 1 year 9 months.川嵜 康大, 松岡 裕大, 西野 仁, 平岡 慎一郎, 磯村 恵美子, 浜口 裕弘, 下顎に発生した顎骨中心性紡錘細胞癌の1例, 日本口腔外科学会雑誌, 2014, 60 巻, 3 号, p. 127-131, 公開日 2015/05/19, Online ISSN 2186-1579, Print ISSN 0021-5163, https://doi.org/10.5794/jjoms.60.127

Synthesis of 5′-Terminal Capped Oligonucleotides Using O–N Phosphoryl Migration of Phosphoramidite Derivatives

Trivalent phosphoramidite derivatives could be readily converted by reacting with 1-hydroxy-7-azabenzotriazole to phosphotriester intermediates; these intermediates reacted smoothly with phosphorylated compounds to give pyrophosphate derivatives. This new phosphorylation approach enabled a facile and rapid synthesis of 5′-adenylated DNA oligomers (A^5′ppDNA) on resins using a silyl-type linker. Our new approach could be applied to the synthesis of a 2′-OMe-RNA oligomer containing the 5′-terminal 2,2,7-trimethylguanosine cap structure

Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2

Ovaj završni rad govori o različitim tehnikama motivacije koje se primjenjuju radi poticanja zaposlenika na učinkovito i uspješno obavljanje zadataka unutar poduzeća. U radu su spomenute različite tehnike motivacije te pojašnjene i definirane svaka od njih. Također, rad govori i općenito o motivaciji, zašto je ona važna i kako uspješno motivirati zaposlenike. Spomenute su i različite individualne karakteristike pojedinca te kako su one povezane sa samom motivacijom pojedinca. Također, prilikom govora o motivaciji važno je spomenuti i vodstvo te kako ono utječe na poslovanje i motiviranost zaposlenika te obratiti pažnju na kvalitetnu i uspješnu suradnju između nadređenog i podređenog

Management of flying insects on expressways through an academic-industrial collaboration: evaluation of the effect of light wavelengths and meteorological factors on insect attraction

Insect outbreaks often occur in the absence of natural enemies and in the presence of excess suitable host materials. Outbreaks of gypsy moths are especially problematic in remote areas located in high-latitude regions in Japan because the majority of adults emerge during the short summer season and initiate synchronous mass flight toward artificial lights. The aggregation of moths in public facilities not only is an annoyance to visitors but also permits the establishment of new populations the following year. The aim of this study was to establish a method to reduce the numbers of large moths that are attracted to lights in the rest areas of expressways in Hokkaido based on the results of research on their behavioral ecology and physiology. First, we conducted extensive insect surveys using light traps that emit light at different wavelengths; the traps were set along the expressways in the summers of 2014-2018. The insects attracted to the light were roughly classified into those showing a preference for broadband light wavelengths (from UV-A to green) and short light wavelengths (from UV-A to blue). The former included aquatic insects and winged ants, and the latter included moths and beetles. Next, we analyzed correlations between moth emergence and daily meteorological data. When gypsy moths were abundant during an outbreak, the daily catch of gypsy moths was positively correlated with the highest ambient temperature on the catch day but not with the visibility range, wind speed, or moon phase. In contrast, the daily catch of oak silkmoths did not correlate with any of these parameters. Our results provide guidance for the management of forest insects inhabiting cool-temperate to subarctic regions based on light wavelengths with reference to weather variables