The Synthesis and Initial Evaluation of MerTK Targeted PET Agents

MerTK (Mer tyrosine kinase), a receptor tyrosine kinase, is ectopically or aberrantly expressed in numerous human hematologic and solid malignancies. Although a variety of MerTK targeting therapies are being developed to enhance outcomes for patients with various cancers, the sensitivity of tumors to MerTK suppression may not be uniform due to the heterogeneity of solid tumors and different tumor stages. In this report, we develop a series of radiolabeled agents as potential MerTK PET (positron emission tomography) agents. In our initial in vivo evaluation, [18F]-MerTK-6 showed prominent uptake rate (4.79 ± 0.24%ID/g) in B16F10 tumor-bearing mice. The tumor to muscle ratio reached 1.86 and 3.09 at 0.5 and 2 h post-injection, respectively. In summary, [18F]-MerTK-6 is a promising PET agent for MerTK imaging and is worth further evaluation in future studies

The Tribological Behaviors in Zr-Based Bulk Metallic Glass with High Heterogeneous Microstructure

Microstructural inhomogeneity of bulk metallic glasses (BMGs) plays a significant role in their mechanical properties. However, there is hardly ant research concerning the influence of heterogeneous microstructures on tribological behaviors. Hence, in this research, the tribological behaviors of different microstructural-heterogeneity BMGs sliding in-air were systematically investigated, and the corresponding wear mechanisms were disclosed via analyzing the chemical composition and morphology of the wear track. Higher microstructural-heterogeneity BMGs can possess a better wear resistance both under dry sliding and a 3.5% NaCl solution. The results suggest that microstructural heterogeneity enhancement is a valid strategy to improve the tribological performance of BMGs

The Synthesis and Initial Evaluation of MerTK Targeted PET Agents

MerTK (Mer tyrosine kinase), a receptor tyrosine kinase, is ectopically or aberrantly expressed in numerous human hematologic and solid malignancies. Although a variety of MerTK targeting therapies are being developed to enhance outcomes for patients with various cancers, the sensitivity of tumors to MerTK suppression may not be uniform due to the heterogeneity of solid tumors and different tumor stages. In this report, we develop a series of radiolabeled agents as potential MerTK PET (positron emission tomography) agents. In our initial in vivo evaluation, [18F]-MerTK-6 showed prominent uptake rate (4.79 ± 0.24%ID/g) in B16F10 tumor-bearing mice. The tumor to muscle ratio reached 1.86 and 3.09 at 0.5 and 2 h post-injection, respectively. In summary, [18F]-MerTK-6 is a promising PET agent for MerTK imaging and is worth further evaluation in future studies

Effect of boron doping gradient on cemented carbide diamond coatings

To improve the binding properties of diamond coating on carbide tools, three micrometer crystal diamond coatings were successfully deposited on YG8 carbide substrate via hot-filament chemical vapor deposition, whose boron gradient ranged from high (HGBMCD) to low (LGBMCD) and zero (MCD). The effect of the gradient size of the decreasing concentration of boron doping method on the nucleation and growth properties of diamond coatings during deposition was investigated. The results showed that the nucleation density of diamond increased with the doping of boron and that the diamond grains became smaller and more uniform after six-hour growth. Among them, the grain size of LGBMCD was mostly in the range of 2 to 3 μm. In addition, the graphite phase in the gradient boron-doped diamond coating was inhibited throughout the growth process, and IDia/IG was up to 14.65 in HGBMCD. The concentrations of the boron and cobalt compounds (i.e., Co2B and CoB) increased as the boron doping gradient decreased. Meanwhile, the residual stress in the diamond coatings gradually changed from compressive stress to tensile stress due to the doping of gradient boron, and the calculated residual stress decreased first and then increased, with the minimum residual stress of –0.255 GPa. Rockwell indentation showed that the gradient doping of boron improved the binding properties of diamond coatings, and that the optimal binding properties were observed at the LGBMCD, which was up to HF2 level at 1 470 N. Therefore, a proper boron doping gradient was demonstrated to improve the quality and binding performance of diamond coatings