High-Responsivity Graphene-Boron Nitride Photodetector and Autocorrelator in a Silicon Photonic Integrated Circuit

Graphene and other two-dimensional (2D) materials have emerged as promising materials for broadband and ultrafast photodetection and optical modulation. These optoelectronic capabilities can augment complementary metal-oxide-semiconductor (CMOS) devices for high-speed and low-power optical interconnects. Here, we demonstrate an on-chip ultrafast photodetector based on a two-dimensional heterostructure consisting of high-quality graphene encapsulated in hexagonal boron nitride. Coupled to the optical mode of a silicon waveguide, this 2D heterostructure-based photodetector exhibits a maximum responsivity of 0.36 A/W and high-speed operation with a 3 dB cut-off at 42 GHz. From photocurrent measurements as a function of the top-gate and source-drain voltages, we conclude that the photoresponse is consistent with hot electron mediated effects. At moderate peak powers above 50 mW, we observe a saturating photocurrent consistent with the mechanisms of electron-phonon supercollision cooling. This nonlinear photoresponse enables optical on-chip autocorrelation measurements with picosecond-scale timing resolution and exceptionally low peak powers

Electrical 2{\pi} phase control of infrared light in a 350nm footprint using graphene plasmons

Modulating the amplitude and phase of light is at the heart of many applications such as wavefront shaping, transformation optics, phased arrays, modulators and sensors. Performing this task with high efficiency and small footprint is a formidable challenge. Metasurfaces and plasmonics are promising , but metals exhibit weak electro-optic effects. Two-dimensional materials, such as graphene, have shown great performance as modulators with small drive voltages. Here we show a graphene plasmonic phase modulator which is capable of tuning the phase between 0 and 2{\pi} in situ. With a footprint of 350nm it is more than 30 times smaller than the 10.6$\mu$m free space wavelength. The modulation is achieved by spatially controlling the plasmon phase velocity in a device where the spatial carrier density profile is tunable. We provide a scattering theory for plasmons propagating through spatial density profiles. This work constitutes a first step towards two-dimensional transformation optics for ultra-compact modulators and biosensing

Tuning quantum non-local effects in graphene plasmonics

The response of an electron system to electromagnetic fields with sharp spatial variations is strongly dependent on quantum electronic properties, even in ambient conditions, but difficult to access experimentally. We use propagating graphene plasmons, together with an engineered dielectric-metallic environment, to probe the graphene electron liquid and unveil its detailed electronic response at short wavelengths.The near-field imaging experiments reveal a parameter-free match with the full theoretical quantum description of the massless Dirac electron gas, in which we identify three types of quantum effects as keys to understanding the experimental response of graphene to short-ranged terahertz electric fields. The first type is of single-particle nature and is related to shape deformations of the Fermi surface during a plasmon oscillations. The second and third types are a many-body effect controlled by the inertia and compressibility of the interacting electron liquid in graphene. We demonstrate how, in principle, our experimental approach can determine the full spatiotemporal response of an electron system.Comment: 8 pages, 4 figure

Thermoelectric detection and imaging of 1 propagating graphene plasmons

Controlling, detecting and generating propagating plasmons by all-electrical means is at the heart of on-chip nano-optical processing1, 2, 3. Graphene carries long-lived plasmons that are extremely confined and controllable by electrostatic fields4, 5, 6, 7; however, electrical detection of propagating plasmons in graphene has not yet been realized. Here, we present an all-graphene mid-infrared plasmon detector operating at room temperature, where a single graphene sheet serves simultaneously as the plasmonic medium and detector. Rather than achieving detection via added optoelectronic materials, as is typically done in other plasmonic systems8, 9, 10, 11, 12, 13, 14, 15, our device converts the natural decay product of the plasmon—electronic heat—directly into a voltage through the thermoelectric effect16, 17. We employ two local gates to fully tune the thermoelectric and plasmonic behaviour of the graphene. High-resolution real-space photocurrent maps are used to investigate the plasmon propagation and interference, decay, thermal diffusion, and thermoelectric generation.Peer ReviewedPostprint (author's final draft

High-Speed Electro-Optic Modulator Integrated with Graphene-Boron Nitride Heterostructure and Photonic Crystal Nanocavity

Nanoscale and power-efficient electro-optic (EO) modulators are essential components for optical interconnects that are beginning to replace electrical wiring for intra- and inter-chip communications. Silicon-based EO modulators show sufficient figures of merits regarding device footprint, speed, power consumption and modulation depth. However, the weak electro-optic effect of silicon still sets a technical bottleneck for these devices, motivating the development of modulators based on new materials. Graphene, a two-dimensional carbon allotrope, has emerged as an alternative active material for optoelectronic applications owing to its exceptional optical and electronic properties. Here, we demonstrate a high-speed graphene electro-optic modulator based on a graphene-boron nitride (BN) heterostructure integrated with a silicon photonic crystal nanocavity. Strongly enhanced light-matter interaction of graphene in a submicron cavity enables efficient electrical tuning of the cavity reflection. We observe a modulation depth of 3.2 dB and a cut-off frequency of 1.2 GHz

MicroRNA-361-3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC

BACKGROUND: Lung cancer is the most common malignancies worldwide. However, the detailed molecular mechanisms underlying lung cancer progression are still not completely clear. MicroRNAs are small noncoding RNAs which occupy a crucial role of cancer metastasis. Accumulating evidence suggests that miR-361 plays important roles in human carcinogenesis. However, its precise biological role remains largely elusive, especially in lung cancer. This study examined the role of miR-361-3p in non-small cell lung cancer (NSCLC). METHODS: Real-time quantitative PCR (qRT-PCR) was used to analyze the expression of miR-361-3p in NSCLC tissue and in compared adjacent non-cancerous tissues. The effect of miR-361-3p on proliferation was evaluated by CCK8 and colony formation assays. The effect of miR-361-3p on migration and invasion was evaluated by transwell assays. Western blotting and immunohistochemical staining were applied to analyze the expression of target proteins and downstream molecule, and the luciferase reporter assay to assess the target genes of miR-361-3p in non-small cell lung cancer cells. RESULTS: miR-361-3p was significantly decreased in NSCLC tissue and cell lines, and its expression levels were highly correlated with lymph node metastasis (P < 0.01) and TNM stages (P < 0.05). Down-regulation of miR-361-3p promoted cell growth, proliferation, colony formation, invasion and migration in vitro, and promoted proliferation and metastasis in vivo (P < 0.01); whereas up-regulation of miR-361-3p had the contrary effects. The luciferase reporter assay showed that SH2B1 was a direct target gene of miR-361-3p. Enforced expression of miR-361-3p inhibited the expression of SH2B1 significantly and the restoration of SH2B1 expression reversed the inhibitory effects of miR-361-3p on NSCLC cell proliferation and metastasis. CONCLUSIONS: miR-361-3p functions as a novel tumor suppressor in NSCLC and the anti-oncogenic activity may involve its inhibition of the target gene SH2B1. These findings suggest the possibility for miR-361-3p as a therapeutic target in NSCLC

Operational performance of a novel fast-responsive heat storage/exchanging unit (HSEU) for solar heating systems

In order for a solar heating system to provide heat immediately after sunrise, a fast response is needed to the heat demand of a serviced space. The majority of existing solar heating systems have a slow response time due to the large volume of water stored in the heat storage/exchanger unit (HSEU). This leads to a slow heat delivery cycle, which results in discomfort for the occupants and thus creates a huge barrier to the wide deployment of solar heating systems. To overcome this critical issue, a novel interactive heat storage/exchanging unit (HSEU) employing a double-tank configuration was developed. Unlike conventional HSEUs, which have a single tank acting as the heat storage and exchanging unit, the new HSEU is comprised of a small tank for heat exchange combined with a large tank for heat storage. The small tank enables fast transfer of solar heat to the heating loop fluid without having to heat up the large volume of water in the entire HSEU tank, whilst the large tank is used to store and exchange heat between itself and the small tank using a temperature-oriented control mechanism. To test the proposed design, the heat transfer between the first (solar loop) and second (heating loop) fluids, the heat and mass transfer between the small and large tank and the associated operational strategy were investigated experimentally and theoretically for comparison. A conventional single tank HSEU requires around 120 min to deliver heat to a served space, whilst the new interactive double-tank HSEU can provide heat to the served space in around 20 min, thus creating a heating system which can respond significantly faster than traditional systems. The investigation of the heat exchange effect between the solar and heating loop fluids showed that the new HSEU achieved a convective heat transfer coefficient of as high as 391 W/m2·K, which is 551% higher than that of a conventional tank. As a result, the solar thermal efficiency of the solar panel-array in the new HSEU based system was increased by 7.5% compared to conventional HSEU based systems

Advances of Treatment about Elderly Clinical Stage I Non-small Cell Lung Cancer

With the aging of the population, the proportion of elderly lung cancer is increasing. More than ten years, lobectomy with mediastinal lymph node dissection has been the standard surgery for stage I non-small cell lung cancer (NSCLC). However, recent studies found that sublobectomy could get the same long-term outcome with the lobectomy for elderly clinical stage I NSCLC and more normal lung tissue could be retained. It becomes controversial again about the standard surgery of stage I NSCLC at present. Elderly stage I NSCLC is a special group, who often can not tolerate thoracotomy because of the poor body function and some comorbidities, but the thoracoscopic surgery and the stereotactic radiotherapy technology (STRT) supply them more options. The treatment of eldly stage I NSCLC is developing towards to the individualization and diversification