3-(2-Amino­ethyl)-2-anilinoquinazolin-4(3H)-one methanol hemisolvate

The title methanol hemisolvated quinazolin-(3H)-one, C16H16N4O·0.5CH3OH, has an anilino substituent in the 2-position and an amino­ethyl substituent in the 3-position of the planar fused-ring system (r.m.s. deviation = 0.019 Å). The anilino N atom donates an intramolecular hydrogen bond to the amino­ethyl N atom. The mol­ecule and the solvent methanol mol­ecule are linked by N—H⋯N, N—H⋯O and O—H⋯O hydrogen bonds. The methanol mol­ecule is disordered over two equally occupied positions about a twofold rotation axis

Acceleration of on-axis and ring-shaped electron beams in wakefields driven by Laguerre-Gaussian pulses

The acceleration of electron beams with multiple transverse structures in wakefields driven by Laguerre-Gaussian pulses has been studied through three-dimensional (3D) particle-in-cell simulations. Under different laser-plasma conditions, the wakefield shows different transverse structures. In general cases, the wakefield shows a donut-like structure and it accelerates the ring-shaped hollow electron beam. When a lower plasma density or a smaller laser spot size is used, besides the donut-like wakefield, a central bell-like wakefield can also be excited. The wake sets in the center of the donut-like wake. In this case, both a central on-axis electron beam and a ring-shaped electron beam are simultaneously accelerated. Further, reducing the plasma density or laser spot size leads to an on-axis electron beam acceleration only. The research is beneficial for some potential applications requiring special pulse beam structures, such as positron acceleration and collimation

High throughput 16SrRNA gene sequencing reveals the correlation between Propionibacterium acnes and sarcoidosis

Sequences of the unique OTUs. (XLS 3616 kb

Interannual variability of the onset of the South China Sea summer monsoon

This article investigates the year-to-year variability of the onset of the South China Sea summer monsoon (SCSSM) and the possible influences exerted by the surface temperature anomalies over land and sea. Early and late monsoon onsets are related to the temperature anomalies in different regions. It is found that an early onset follows negative sea surface temperature (SST) anomalies in the central tropical Pacific (CP) Ocean during the preceding winter and spring, corresponding to a CP La Niña. In contrast, a late onset is preceded by the negative surface air temperature anomalies over land in the central Asian continent. Negative SST anomalies in the central-eastern equatorial Pacific Ocean and the associated warming in the western Pacific induce an anomalously enhanced Walker circulation. This anomalous Walker cell leads to an increase in convection, causing more latent heat release and a subsequent decrease of surface pressure. The anomalous Walker cell and the enhanced latent heat release weaken the Western North Pacific subtropical high and the Philippine Sea anticyclone, favouring a westerly flow from the Indian Ocean, resulting in an early SCSSM onset. On the other hand, negative land surface temperature anomalies cool the atmosphere over land, and locally modify the Hadley circulation, accompanied by the anomalous divergence in the low-level atmosphere over the western equatorial Pacific. This divergence anomaly reduces the latent heat release and strengthens the anticyclone in the Philippine Sea, thus preventing the westward extension of the westerlies from the Indian Ocean and causing a late SCSSM onset.This research was jointly supported by the Geographical Modeling and Geocomputation Program under the Focused Investment Scheme of The Chinese University of Hong Kong, the National Basic Research Program (973 Program) of China (No. 2012CB955800), and the National Natural Science Foundation of China (No. 41401052).This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1002/joc.436

Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

SummarySomatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors. However, the low efficiency and slow kinetics of the reprogramming process have hampered progress with this technology. Here we report that a natural compound, vitamin C (Vc), enhances iPSC generation from both mouse and human somatic cells. Vc acts at least in part by alleviating cell senescence, a recently identified roadblock for reprogramming. In addition, Vc accelerates gene expression changes and promotes the transition of pre-iPSC colonies to a fully reprogrammed state. Our results therefore highlight a straightforward method for improving the speed and efficiency of iPSC generation and provide additional insights into the mechanistic basis of the reprogramming process

Secrets of RLHF in Large Language Models Part I: PPO

Large language models (LLMs) have formulated a blueprint for the advancement of artificial general intelligence. Its primary objective is to function as a human-centric (helpful, honest, and harmless) assistant. Alignment with humans assumes paramount significance, and reinforcement learning with human feedback (RLHF) emerges as the pivotal technological paradigm underpinning this pursuit. Current technical routes usually include \textbf{reward models} to measure human preferences, \textbf{Proximal Policy Optimization} (PPO) to optimize policy model outputs, and \textbf{process supervision} to improve step-by-step reasoning capabilities. However, due to the challenges of reward design, environment interaction, and agent training, coupled with huge trial and error cost of large language models, there is a significant barrier for AI researchers to motivate the development of technical alignment and safe landing of LLMs. The stable training of RLHF has still been a puzzle. In the first report, we dissect the framework of RLHF, re-evaluate the inner workings of PPO, and explore how the parts comprising PPO algorithms impact policy agent training. We identify policy constraints being the key factor for the effective implementation of the PPO algorithm. Therefore, we explore the PPO-max, an advanced version of PPO algorithm, to efficiently improve the training stability of the policy model. Based on our main results, we perform a comprehensive analysis of RLHF abilities compared with SFT models and ChatGPT. The absence of open-source implementations has posed significant challenges to the investigation of LLMs alignment. Therefore, we are eager to release technical reports, reward models and PPO code

Pairing symmetry and properties of iron-based high temperature superconductors

Pairing symmetry is important to indentify the pairing mechanism. The analysis becomes particularly timely and important for the newly discovered iron-based multi-orbital superconductors. From group theory point of view we classified all pairing matrices (in the orbital space) that carry irreducible representations of the system. The quasiparticle gap falls into three categories: full, nodal and gapless. The nodal-gap states show conventional Volovik effect even for on-site pairing. The gapless states are odd in orbital space, have a negative superfluid density and are therefore unstable. In connection to experiments we proposed possible pairing states and implications for the pairing mechanism.Comment: 4 pages, 1 table, 2 figures, polished versio