Organic–Inorganic Hybrid Nanosystems for Photodynamic Therapy

The purpose of this study is to investigate the possibility of improving the efficiency of a photosensitizer utilizing colloidal semiconductor quantum dots as light-harvesting nanoantenna and reveal the mechanism of this enhancement. Keywords: quantum dots, photosensitizer, photodynamic therapy, FRET, charge transfe

A preliminary factor analytic investigation into the first-order factor structure of the Fifteen Factor Plus (15FQ+) on a sample of Black South African managers

The original publication is available at http://www.sajip.co.zaMoyo, S. & Theron, C. 2011. A preliminary factor analytic investigation into the first-order factor structure of the Fifteen Factor Plus (15FQ+) on a sample of Black South African managers. SA Journal of Industrial Psychology, 37(1), 1-22, doi: 10.4102/sajip.v37i1.934.Orientation: The Fifteen Factor Questionnaire Plus (15FQ+) is a prominent personality questionnaire that organisations frequently use in personnel selection in South Africa. Research purpose: The primary objective of this study was to undertake a factor analytic investigation of the first-order factor structure of the 15FQ+. Motivation for the study: The construct validity of the 15FQ+, as a measure of personality, is necessary even though it is insufficient to justify its use in personnel selection. Research design, approach and method: The researchers evaluated the fit of the measurement model, which the structure and scoring key of the 15FQ+ implies, in a quantitative study that used an ex post facto correlation design through structural equation modelling. They conducted a secondary data analysis. They selected a sample of 241 Black South African managers from a large 15FQ+ database. Main findings: The researchers found good measurement model fit. The measurement model parameter estimates were worrying. The magnitude of the estimated model parameters suggests that the items generally do not reflect the latent personality dimensions the designers intended them to with a great degree of precision. The items are reasonably noisy measures of the latent variables they represent. Practical/managerial implications: Organisations should use the 15FQ+ carefully on Black South African managers until further local research evidence becomes available. Contribution/value-add: The study is a catalyst to trigger the necessary additional research we need to establish convincingly the psychometric credentials of the 15FQ+ as a valuable assessment tool in South Africa.Publisher's versio

CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy

We have studied the photodynamic properties of novel CdTe quantum dots—methylene blue hybrid photosensitizer. Absorption spectroscopy, photoluminescence spectroscopy, and fluorescence lifetime imaging of this system reveal efficient charge transfer between nanocrystals and the methylene blue dye. Near-infrared photoluminescence measurements provide evidence for an increased efficiency of singlet oxygen production by the methylene blue dye. In vitro studies on the growth of HepG2 and HeLa cancerous cells were also performed, they point toward an improvement in the cell kill efficiency for the methylene blue-semiconductor nanocrystals hybrid system

Electron-phonon interaction effects in semiconductor quantum dots: a non-perturbative approach

Multiphonon processes in a model quantum dot (QD) containing two electronic states and several optical phonon modes are considered by taking into account both intra- and nterlevel terms. The Hamiltonian is exactly diagonalized, including a finite number of multiphonon processes large enough to guarantee that the result can be considered exact in the physically important energy region. The physical properties are studied by calculating the electronic Green’s function and the QD dielectric function. When both the intra- and interlevel interactions are included, the calculated spectra allow several previously published experimental results obtained for spherical and self-assembled QD’s, such as enhanced two-LO-phonon replica in absorption spectra and up-converted photoluminescence to be explained. An explicit calculation of the spectral line shape due to intralevel interaction with a continuum of acoustic phonons is presented, where the multiphonon processes also are shown to be important. It is pointed out that such an interaction, under certain conditions, can lead to relaxation in the otherwise stationary polaron system.Fundação para a Ciência e a Tecnologia (FCT

Induction of protein citrullination and auto-antibodies production in murine exposed to nickel

Abstract Citrullination, or the post-translational deimination of polypeptide-bound arginine, is involved in several pathological processes in the body, including autoimmunity and tumorigenesis. Recent studies have shown that nanomaterials can trigger protein citrullination, which might constitute a common pathogenic link to disease development. Here we demonstrated auto-antibody production in serum of nanomaterials-treated mice. Citrullination-associated phenomena and PAD levels were found to be elevated in nanomaterials -treated cell lines as well as in the spleen, kidneys and lymph nodes of mice, suggesting a systemic response to nanomaterials injection, and validated in human pleural and pericardial malignant mesothelioma (MM) samples. The observed systemic responses in mice exposed to nanomaterials support the evidence linking exposure to environmental factors with the development of autoimmunity responses and reinforces the need for comprehensive safety screening of nanomaterials. Furthermore, these nanomaterials induce pathological processes that mimic those observed in Pleural MM, and therefore require further investigations into their carcinogenicity

Luminescence Spectra of Quantum-Sized CdS and PbI2\text{}_{2} Particles in Static Electric Field

The influence of external electric field was studied on the luminescence behavior of quantum-sized CdS and PbI$\text{}_{2}$ nanocrystals, embedded in various polymeric films. The clear increase in the photoluminescence intensity from the quantum-sized particles was observed, as well as the spectral shift of photoluminescence bands. The mechanism proposed is based on the field-induced oxygen desorption from the nanocrystal surface which is the good photoluminescence inhibitor