34 research outputs found
Bose-Einstein condensation of magnons under incoherent pumping
Bose-Einstein condensation in a gas of magnons pumped by an incoherent
pumping source is experimentally studied at room temperature. We demonstrate
that the condensation can be achieved in a gas of bosons under conditions of
incoherent pumping. Moreover, we show the critical transition point is almost
independent of the frequency spectrum of the pumping source and is solely
determined by the density of magnons. The electromagnetic power radiated by the
magnon condensate was found to scale quadratically with the pumping power,
which is in accordance with the theory of Bose-Einstein condensation in magnon
gases
Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU
Contains fulltext :
172380.pdf (publisher's version ) (Open Access
A saturated map of common genetic variants associated with human height
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes(1). Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel(2)) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants
A saturated map of common genetic variants associated with human height.
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
High-speed optoelectronic effects arising under intensive picosecond stimulated emission in GaAs
A number of optoelectronic threshold effects arising under intensive stimulated radiative recombination of hot dense electron-hole plasma (EHP) in a thin (~1um) epitaxial layer of GaAs has been revealed. These effects' build-up and decay time intervals are of ~10 ps or less at room temperature (which makes it possible to modulate the optical and electrical properties of semiconductor heterostructures and devices with a frequency of ~ 100 GHz). These effects are observed when the stimulated recombination emission appears in picoseconds. The emission intensity can be as high as ~108 W/cm2 and the EHP concentration can change several times by magnitude. The revealed class of optoelectronic effects has its origin in strong mutual influence between the stimulated emission and dynamical processes in dense EHP. The acquired knowledge of somewhat uncommon mechanism of changes of EHP concentration and temperature, of intensity and spectrum of stimulated emission, of the gain, transparency, band-gap width, etc. can be used for successful construction of semiconductor high-speed powerful optoelectronic devices (such as semiconductor lasers and superluminescence diodes, semiconductor light-wave converters, modulators of the optical transparency and photoconductivity7