Phoebe's orbit from ground-based and space-based observations

The ephemeris of Phoebe, the ninth satellite of Saturn, is not very accurate. Previous dynamical models were usually too simplified, the astrometry is heterogeneous and, the Saturn's ephemeris itself is an additionnal source of error. The aim is to improve Phoebe's ephemeris by using a large set of observations, correcting some systematic errors and updating the dynamical model. The dynamical model makes use of the most recent ephemeris of planets and Saturnian satellites. The astrometry of Phoebe is improved by using a compilation of ground-based and space-based observations and by correcting the bias in stellar catalogues used for the reduction. We present an accurate ephemeris of Phoebe with residuals of 0.45 arcsec and with an estimated accuracy of Phoebe's position of less that 100 km on 1990-2020 period.Comment: 10 pages, 9 figures, accepted by A&

(S)-Benzyl 2-amino-3-(4-hydroxy­phen­yl)propanoate

The title compound, C16H17NO3, adopts a folded conformation in the crystal structure. The crystal packing is stabilized by inter­molecular O—H⋯O and N—H⋯O hydrogen-bonding inter­actions. The absolute configuration was assigned assuming that the absolute configuration of the starting material l-tyrosine was retained during the synthesis

Measurements of Rayleigh Ratios in Linear Alkylbenzene

In present work an experiment has been designed to measure the Rayleigh ratio directly at $405$ nm and $432$ nm for linear alkylbenzene which is a common solvent used in liquid scintillator detectors of neutrino experiments. The perpendicularly polarized Rayleigh ratio is determined to be $(4.52\pm 0.28)\times 10^{-6}$ m$^{-1}\cdot$ sr$^{-1}$ at $405$ nm and $(3.82\pm 0.24)\times 10^{-6}$ m$^{-1}\cdot$ sr$^{-1}$ at $432$ nm, and the corresponding Rayleigh scattering length is $L_{Ray} = 22.9\pm 0.3(\mathrm{stat.})\pm 1.7(\mathrm{sys.})$ m at $405$ nm and $L_{Ray}= 27.0\pm 0.9(\mathrm{stat.})\pm 1.8(\mathrm{sys.})$ m at $432$ nm.Comment: 16 pages, 7 figure

Increased Methylation of the MOR Gene Proximal Promoter in Primary Sensory Neurons Plays a Crucial Role in the Decreased Analgesic Effect of Opioids in Neuropathic Pain

BACKGROUND: The analgesic potency of opioids is reduced in neuropathic pain. However, the molecular mechanism is not well understood. RESULTS: The present study demonstrated that increased methylation of the Mu opioid receptor (MOR) gene proximal promoter (PP) in dorsal root ganglion (DRG) plays a crucial role in the decreased morphine analgesia. Subcutaneous (s.c.), intrathecal (i.t.) and intraplantar (i.pl.), not intracerebroventricular (i.c.v.) injection of morphine, the potency of morphine analgesia was significantly reduced in nerve-injured mice compared with control sham-operated mice. After peripheral nerve injury, we observed a decreased expression of MOR protein and mRNA, accompanied by an increased methylation status of MOR gene PP, in DRG. However, peripheral nerve injury could not induce a decreased expression of MOR mRNA in the spinal cord. Treatment with 5-aza-2′-deoxycytidine (5-aza-dC), inhibited the increased methylation of MOR gene PP and prevented the decreased expression of MOR in DRG, thereby improved systemic, spinal and periphery morphine analgesia. CONCLUSIONS: Altogether, our results demonstrate that increased methylation of the MOR gene PP in DRG is required for the decreased morphine analgesia in neuropathic pain

Correlation between diopters and refractive parameters among 5 to 12 years old school-age children of Lanzhou city

AIM: To investigate the epidemiological status of refractive state among school-age children of 5 to 12 years in Chengguan district of Lanzhou city, and to analyze the correlation with axial length(AL), horizontal and vertical corneal refractive power(K1, K2), anterior chamber depth(ACD)and corneal diameter(W-W). <p>METHODS: The value of AL, K1, K2, ACD and W-W of 813 school-age children(1626 eyes)aged 8.46±2.30 years old(5-12 years)were measured by IOL-Master, refractive error was measured by computer refractor. The eyes were divided into 5 groups according to different mean spherical equivalent(SE)diopter: high myopia, moderate myopia, low myopia, emmetropia and hyperopia. The correlation between diopter and different refractive parameters of different ages and different diopter groups were analyzed respectively, the SPSS 19.0 was used for the statistical analysis.<p>RESULTS: There were statistically significant difference(<i>P</i><0.05)in uncorrected visual acuity and refractive state among the different groups of 5-12 years school-age children, the prevalence of myopia tended to increase with the age. There were statistically significant difference in AL and ACD among the different age groups(<i>P</i><0.05), AL and ACD increased with the age. There were statistically significant difference in AL among three myopic groups(<i>P</i><0.05). There were statistically significant difference in ACD between low myopia and moderate myopia, low myopia and high myopia(<i>P</i><0.05). There were statistically significant difference in corneal refractive power and corneal diameter between low myopia and high myopia, moderate myopia and high myopia(<i>P</i><0.05). SE was negatively correlated with AL(<i>r</i>=-0.764, <i>P</i><0.01)and ACD(<i>r</i>=-0.498, <i>P</i><0.01), but had week correlation with corneal refractive power or corneal diameter.<p>CONCLUSION: The increase of AL plays an important role in the changes of refractive among school-age children of 5-12 years, AL is the main morphological variable related to myopia. Meanwhile, refractive changes may be affected by corneal refractive power(K1, K2), ACD and corneal diameter(W-W). 7-8 years old can be regarded as the main phase from emmetropization to myopization of school-age children

(E)-2-Hydroxy­naphthalene-1-carb­al­de­hyde semicarbazone

The title compound, C12H11N3O2, adopts an E or trans configuration with respect to the C=N bond. There is an intra­molecular O—H⋯N hydrogen bond involving the hydroxyl H atom and an N atom of the hydrazine group. In the crystal structure, mol­ecules are connected via N—H⋯O hydrogen bonds, forming a three-dimensional network

Therapeutic Effects of Water Extract of Arisaema Erubescens Tubers on Type II Collagen-induced Arthritis in Rats

Purpose: To investigate the anti-arthritic activity of the water extract of Rhizoma Arisaematis (WERA) using collagen II (CII)-induced arthritis (CIA) rat model.Methods: CIA was induced in male Sprague-Dawley rat by intra dermal injection of bovine collagen type II (C II) in Freund’s complete adjuvant (cFA). The rats were treated daily for 21 consecutive days with WERA at doses of 100, 200, and 400 mg/kg. Methotrexate (MTX) was used as positive control, and administered at a dose of 3 mg/kg intraperitoneally in two-weekly cycles for 3 weeks. Severity of arthritis was evaluated by arthritic scores, including paw swelling, arthritic score, body weight, thymus index and spleen index. The levels of IL-1β, IL-6, IL-10 and TNF-α in serum were also measured.Results: The results revealed that WERA significantly inhibited paw edema (p-value &lt; 0.01), decreased arthritis scores (p-value &lt; 0.01) and spleen index (p-value &lt; 0.05), and alleviated the weight loss of CIA rats. Furthermore, the pro-inflammatory cytokines of TNF-α (19.3%, 60.5% and 73.9%, respectively), IL- 1β (7.9%, 41.1% and 52.7%, respectively) and IL-6 (26.6%, 48.0% and 72.2%, respectively) were remarkably attenuated in serum of all WERA treated rats, however, IL-10 (72.4% and 39.1%, respectively) was markedly increased at doses of 200 and 400 mg/kg of WERA.Conclusion: The results demonstrate that WERA exerts therapeutic effects in collagen--induced arthritis of rats by decreasing the levels of TNF-α, IL-1β, IL-6 and IL-10 in serum, and therefore may be an effective candidate drug for the treatment of human rheumatoid arthritis.Keywords: Rhizoma Arisaematis, Rheumatoid arthritis, Inflammatory, Cytokines, Freund’s complete adjuvan

Effect of Arisaema erubescens (Wall) Schott rhizome extract on rheumatoid arthritis

Purpose: To investigate the anti-arthritic activity of the water extract of Rhizoma Arisaematis (WERA) using a collagen II -induced arthritis (CIA) rat model.Methods: CIA was induced in male Sprague-Dawley rats by intradermal injection of bovine collagen II in Complete Freund’s Adjuvant. The rats were treated with daily oral doses of WERA (100, 200, and 400 mg/kg) for 21 consecutive days. Methotrexate (MTX, 3 mg/kg), used as a positive control, was administered orally 2 times/week for 3 weeks. The severity of arthritis was evaluated using indices of paw swelling, arthritic score, body weight, thymus index, and spleen index. In addition, the serum levels of IL-1β, IL-6, IL-10, and TNF-α were measured.Results: All doses of WERA significantly inhibited paw edema (p &lt; 0.01), decreased arthritis scores (p &lt; 0.01) and spleen index (p &lt; 0.05), and alleviated the weight loss associated with CIA in rats. Furthermore, TNF-α, IL-1β, and IL-6 serum levels were significantly decreased (p &lt; 0.05) by all doses of WERA. By contrast, IL-10 serum levels were markedly increased (p &lt; 0.05).Conclusion: WERA exerts therapeutic effects in CIA in rats by decreasing the serum levels of TNF-α, IL-1β, IL-6 and IL-10, suggesting WERA may be an effective candidate drug for treating human rheumatoid arthritis.Keywords: Rhizoma Arisaematis, Rheumatoid arthritis, Inflammatory, Cytokines, Freund’s complete adjuvan