14,730 research outputs found
Click-aware purchase prediction with push at the top
Eliciting user preferences from purchase records for performing purchase
prediction is challenging because negative feedback is not explicitly observed,
and because treating all non-purchased items equally as negative feedback is
unrealistic. Therefore, in this study, we present a framework that leverages
the past click records of users to compensate for the missing user-item
interactions of purchase records, i.e., non-purchased items. We begin by
formulating various model assumptions, each one assuming a different order of
user preferences among purchased, clicked-but-not-purchased, and non-clicked
items, to study the usefulness of leveraging click records. We implement the
model assumptions using the Bayesian personalized ranking model, which
maximizes the area under the curve for bipartite ranking. However, we argue
that using click records for bipartite ranking needs a meticulously designed
model because of the relative unreliableness of click records compared with
that of purchase records. Therefore, we ultimately propose a novel
learning-to-rank method, called P3Stop, for performing purchase prediction. The
proposed model is customized to be robust to relatively unreliable click
records by particularly focusing on the accuracy of top-ranked items.
Experimental results on two real-world e-commerce datasets demonstrate that
P3STop considerably outperforms the state-of-the-art implicit-feedback-based
recommendation methods, especially for top-ranked items.Comment: For the final published journal version, see
https://doi.org/10.1016/j.ins.2020.02.06
rMAPS: RNA map analysis and plotting server for alternative exon regulation.
RNA-binding proteins (RBPs) play a critical role in the regulation of alternative splicing (AS), a prevalent mechanism for generating transcriptomic and proteomic diversity in eukaryotic cells. Studies have shown that AS can be regulated by RBPs in a binding-site-position dependent manner. Depending on where RBPs bind, splicing of an alternative exon can be enhanced or suppressed. Therefore, spatial analyses of RBP motifs and binding sites around alternative exons will help elucidate splicing regulation by RBPs. The development of high-throughput sequencing technologies has allowed transcriptome-wide analyses of AS and RBP-RNA interactions. Given a set of differentially regulated alternative exons obtained from RNA sequencing (RNA-seq) experiments, the rMAPS web server (http://rmaps.cecsresearch.org) performs motif analyses of RBPs in the vicinity of alternatively spliced exons and creates RNA maps that depict the spatial patterns of RBP motifs. Similarly, rMAPS can also perform spatial analyses of RBP-RNA binding sites identified by cross-linking immunoprecipitation sequencing (CLIP-seq) experiments. We anticipate rMAPS will be a useful tool for elucidating RBP regulation of alternative exon splicing using high-throughput sequencing data
Biodiv: Business approach to protect biodiversity in agriculture
To make biodiversity as a standard for selection (purchase), Biodiv Inc. aims at balancing between biodiversity conservation and agricultural productivity that allows farmers to have economic profits
Real-Time Robot Software Platform for Industrial Application
In this study, we present the requirements of a real-time robot software (SW) platform that can be used for industrial robots and examine whether various kinds of existing middleware satisfy them. Moreover, we propose a real-time robot SW platform that extends RTMIA to various industrial applications, which is implemented on Xenomai real-time operating system and Linux. The proposed SW platform utilizes the timer-interrupt based approach to keep strict period and the shared memory for convenient usage, on which the shared variable is designed and used. We verify the proposed platform by showing that the robot task and the Programmable Logic Controller (PLC) program are performing with interlocking each other on the presented platform
Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation
Cinchonine (C19H22N2O) is a natural compound of Cinchona bark. Although cinchonine's antiplatelet effect has been reported in the previous study, antiobesity effect of cinchonine has never been studied. The main objective of this study was to investigate whether cinchonine reduces high-fat-diet- (HFD-) induced adipogenesis and inflammation in the epididymal fat tissues of mice and to explore the underlying mechanisms involved in these reductions. HFD-fed mice treated with 0.05% dietary cinchonine for 10 weeks had reduced body weight gain (−38%), visceral fat-pad weights (−26%), and plasma levels of triglyceride, free fatty acids, total cholesterol, and glucose compared with mice fed with the HFD. Moreover, cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice. Cinchonine also attenuated the HFD-induced upregulation of proinflammatory cytokines by inhibiting toll-like-receptor-2- (TLR2-) and TLR4-mediated signaling cascades in the adipose tissue of mice. Our findings suggest that dietary cinchonine with its effects on adipogenesis and inflammation may have a potential benefit in preventing obesity
Moisture-triggered physically transient electronics
Physically transient electronics, a form of electronics that can physically disappear in a controllable manner, is very promising for emerging applications. Most of the transient processes reported so far only occur in aqueous solutions or biofluids, offering limited control over the triggering and degradation processes. We report novel moisture-triggered physically transient electronics, which exempt the needs of resorption solutions and can completely disappear within well-controlled time frames. The triggered transient process starts with the hydrolysis of the polyanhydride substrate in the presence of trace amounts of moisture in the air, a process that can generate products of corrosive organic acids to digest various inorganic electronic materials and components. Polyanhydride is the only example of polymer that undergoes surface erosion, a distinct feature that enables stable operation of the functional devices over a predefined time frame. Clear advantages of this novel triggered transience mode include that the lifetime of the devices can be precisely controlled by varying the moisture levels and changing the composition of the polymer substrate. The transience time scale can be tuned from days to weeks. Various transient devices, ranging from passive electronics (such as antenna, resistor, and capacitor) to active electronics ( such as transistor, diodes, optoelectronics, and memories), and an integrated system as a platform demonstration have been developed to illustrate the concept and verify the feasibility of this design strategy
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