Java-based digital library portal for geography education

AbstractG-Portal is a Java-based digital library system for managing the metadata of geography related resources on the Web. In addition to providing a flexible repository subsystem to accommodate metadata of different formats using XML and XML Schemas, G-Portal organizes metadata into projects and layers, and supports an integrated and synchronized classification and map-based interfaces over the stored metadata. G-Portal also includes a classification subsystem that creates category structures and classifies metadata resources into categories based on user-specified classification schemas. Furthermore, G-Portal users can annotate resources and make their annotations available to others. In this paper, we describe the design and implementation of G-Portal and elaborate how Java is used to implement its features. G-Portal has been designed to be modular and some of the modules can be used as stand-alone tools. In this paper, we use UML notation to describe the detailed design of G-Portal and highlight some of the design decisions

Genetic diversity and population structure of terapon jarbua (Forskål, 1775) (teleostei, terapontidae) in malaysian waters

A background study is important for the conservation and stock management of a species. Terapon jarbua is a coastal Indo-Pacific species, sourced for human consumption. This study examined 134 samples from the central west and east coasts of Peninsular (West) Malaysia and East Malaysia. A 1446-bp concatenated dataset of mtDNA COI and Cyt b sequences was used in this study and 83 haplotypes were identified, of which 79 are unique haplotypes and four are shared haplotypes. Populations of T. jarbua in Malaysia are genetically heterogenous as shown by the high level of haplotype diversity ranging from 0.9167–0.9952, low nucleotide diversity ranging from 0.0288–0.3434, and high FST values (within population genetic variation). Population genetic structuring is not distinct as shown by the shared haplotypes between geographic populations and mixtures of haplotypes from different populations within the same genetic cluster. The gene flow patterns and population structuring observed among these regions are likely attributed to geographical distance, past historical events, allopatric speciation, dispersal ability and water currents. For instance, the mixture of haplotypes revealed an extraordinary migration ability of T. jarbua (>1200 km) via ancient river connectivity. The negative overall value of the neutrality test and a non-significant mismatch distribution are consistent with demographic expansion(s) in the past. The median-joining network concurred with the maximum likelihood haplotype tree with three major clades resolved. The scarcity of information on this species is an obstacle for future management and conservation purposes. Hence, this study aims to contribute information on the population structure, genetic diversity, and historical demography of T. jarbua in Malaysia

Multifunctional Compounds for Activation of the p53‐Y220C Mutant in Cancer

The p53 protein plays a major role in cancer prevention, and over 50 % of cancer diagnoses can be attributed to p53 malfunction. The common p53 mutation Y220C causes local protein unfolding, aggregation, and can result in a loss of Zn in the DNA‐binding domain. Structural analysis has shown that this mutant creates a surface site that can be stabilized using small molecules, and herein a multifunctional approach to restore function to p53‐Y220C is reported. A series of compounds has been designed that contain iodinated phenols aimed for interaction and stabilization of the p53‐Y220C surface cavity, and Zn‐binding fragments for metallochaperone activity. Their Zn‐binding affinity was characterized using spectroscopic methods and demonstrate the ability of compounds L4 and L5 to increase intracellular levels of Zn2+ in a p53‐Y220C‐mutant cell line. The in vitro cytotoxicity of our compounds was initially screened by the National Cancer Institute (NCI‐60), followed by testing in three stomach cancer cell lines with varying p53 status’, including AGS (WTp53), MKN1 (V143A), and NUGC3 (Y220C). Our most promising ligand, L5, is nearly 3‐fold more cytotoxic than cisplatin in a large number of cell lines. The impressive cytotoxicity of L5 is further maintained in a NUGC3 3D spheroid model. L5 also induces Y220C‐specific apoptosis in a cleaved caspase‐3 assay, reduces levels of unfolded mutant p53, and recovers p53 transcriptional function in the NUGC3 cell line. These results show that these multifunctional scaffolds have the potential to restore wild‐type function in mutant p53‐Y220C

Morbidity And Mortality in Patients After Skull Base Osteomyelitis. A Report of 3 Cases and Review of the Literature. (.pdf)

Skull base osteomyelitis (SBO) is an uncommon but life threatening condition, most commonly secondary to otitis externa (1). We report 3 cases of SBO which presented with neuro-ophthalmic manifestations without aural pathology. Knowledge of SBO by the neuro-ophthalmologist is essential

Early interventions for tentorial dural arteriovenous fistula

Dural arteriovenous fistulae (DAVF) constitute 10–15% of all intracranial vascular malformations. As a subtype of DAVF, tentorial DAVF are even rarer, but their aggressive nature warrants early intervention. With regards to symptoms, 70–88% of the cases present with bruits or tinnitus, 60–74% with intracranial haemorrhages, 23–42% with central nerve deficits, 14–17% with cranial nerve deficits, and finally 8–25 % with headaches. Here we report three cases of tentorial DAVF with a primary manifestation of headaches: the first patient is a 44-year-old woman who presented with a severe, persistent sharp occipital headache for 1 day. She deteriorated quickly after admission and required emergency posterior fossa decompression for evacuation of an acute right cerebellar haematoma. Intra-operative and pathological findings suggested a cerebellar arteriovenous malformation. She subsequently underwent transarterial embolisation and surgical excision of the lesion. A review of the histopathological features will be presented. The second case is a 61-year-old male with a 3–4-day history of headache and vomiting prior to presenting to the emergency department with acute delirium secondary to subarachnoid haemorrhage in the posterior fossa. The third case is a 55-year-old woman with moderate, recurrent generalised headaches for 4–5 years. She was managed expediently with transarterial embolisation and had a good outcome. In view of the poor prognosis associated with DAVF rupture, early diagnosis and treatment is warranted to achieve favourable outcomes

Long-term follow-up after percutaneous coronary intervention in patients with systemic lupus erythematosus

International Journal of Cardiology1263430-43

Chasing dead ends《尋》

Veteran tomb hunter Raymond Goh and his companions, Peter Pak and Ah Beng, routinely comb Bukit Brown and its surrounding cemeteries in search of ancestry in hidden headstones and traces of life in overgrown landscapes. Animated by their affection for history and discovery, Chasing Dead Ends is a roving eye documentary short that follows a trio of intrepid explorers as they unearth human heritage from the grave and behold the unfiltered beauty of our forgotten monuments.Bachelor of Communication Studie

Low Grade Glioma of the Pituitary Stalk

"In adults, thickening of the pituitary stalk can be the result of primary or secondary tumours, inflammatory or vascular lesions.1 Glioma of the pituitary stalk is rare. Only two other cases have been reported in the English literature.2,3. Clinical, imaging and pathological features of this rare tumour will be presented.