OCI-Based Group Communication Support in CORBA

Group communication is a useful mechanism guaranteeing consistency among replicated objects. The existing approaches do not allow transparent plug-in of group communication protocols into CORBA. They either require modification of CORBA or OS, or provide no room for incorporating group communication transport protocols into CORBA. We thus propose a generic group communication framework that allows transparent plug-in of various group communication protocols with no modification of existing CORBA. We extend the open communications interface (OCI) to support interoperability, reusability of existing group communication, and independency on ORB and OS. We also define the group communication inter-ORB protocol (GCIOP) as a group communication instantiation of the general inter-ORB protocol (GIOP) that encapsulates underlying group communication protocols. The proposed scheme can be exploited for fault-tolerant CORBA (FT CORBA)

OCI-Based Group Communication Support in CORBA

Group communication is a useful mechanism guaranteeing consistency among replicated objects. The existing approaches do not allow transparent plug-in of group communication protocols into CORBA. They either require modification of CORBA or OS, or provide no room for incorporating group communication transport protocols into CORBA. We thus propose a generic group communication framework that allows transparent plug-in of various group communication protocols with no modification of existing CORBA. We extend the open communications interface (OCI) to support interoperability, reusability of existing group communication, and independency on ORB and OS. We also define the group communication inter-ORB protocol (GCIOP) as a group communication instantiation of the general inter-ORB protocol (GIOP) that encapsulates underlying group communication protocols. The proposed scheme can be exploited for fault-tolerant CORBA (FT CORBA)

BRL1 and BRL3 are novel brassinosteroid receptors that function in vascular differentiation in Arabidopsis

Plant steroid hormones, brassinosteroids (BRs), are perceived by the plasma membrane-localized leucine-rich-repeat-receptor kinase BRI1. Based on sequence similarity, we have identified three members of the BRI1 family, named BRL1, BRL2 and BRL3. BRL1 and BRL3, but not BRL2, encode functional BR receptors that bind brassinolide, the most active BR, with high affinity. In agreement, only BRL1 and BRL3 can rescue bri1 mutants when expressed under the control of the BRI1 promoter. While BRI1 is ubiquitously expressed in growing cells, the expression of BRL1 and BRL3 is restricted to non-overlapping subsets of vascular cells. Loss-of-function of brl1 causes abnormal phloem:xylem differentiation ratios and enhances the vascular defects of a weak bri1 mutant. bri1 brl1 brl3 triple mutants enhance bri1 dwarfism and also exhibit abnormal vascular differentiation. Thus, Arabidopsis contains a small number of BR receptors that have specific functions in cell growth and vascular differentiation.Fil: Caño Delgado, Ana. Salk Institute. Plant Biology Laboratory; Estados Unidos. Howard Hughes Medical Institute; Estados UnidosFil: Yin, Yanhai. Howard Hughes Medical Institute; Estados Unidos. Salk Institute. Plant Biology Laboratory; Estados UnidosFil: Yu, Cong. University of Michigan; Estados UnidosFil: Vafeados, Dionne. Howard Hughes Medical Institute; Estados Unidos. Salk Institute. Plant Biology Laboratory; Estados UnidosFil: Mora Garcia, Santiago. Howard Hughes Medical Institute; Estados Unidos. Salk Institute. Plant Biology Laboratory; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Cheng, Jin Chen. University of Michigan; Estados UnidosFil: Nam, Kyoung Hee. University of Michigan; Estados UnidosFil: Li, Jianming. University of Michigan; Estados UnidosFil: Chory, Joanne. Salk Institute. Plant Biology Laboratory; Estados Unidos. Howard Hughes Medical Institute; Estados Unido

17β-Estradiol strongly inhibits azoxymethane/dextran sulfate sodium-induced colorectal cancer development in Nrf2 knockout male mice

© 2020 The Author(s)Nuclear factor erythroid 2-related factor 2 (Nrf2) has dual effects on inflammation and cancer progression depending on the microenvironment. Estrogens have a protective effect on colorectal cancer (CRC) development. The aim of this study was to investigate CRC development in Nrf2 knockout (KO) mice. Azoxymethane (AOM) and dextran sulfate sodium (DSS)-treated wild-type (WT) and Nrf2 KO male mice were sacrificed at weeks 2 and 16 after AOM injection with/without 17β-estradiol (E2) treatment during week 1. Disease activity index and colon tissue damage at week 2 showed strong attenuation following E2 administration in WT mice but to a lesser extent in Nrf2 KO male mice. At week 16, E2 significantly diminished AOM/DSS-induced adenoma/cancer incidence at distal colon in the Nrf2 KO group, but not in the WT. Furthermore, mRNA or protein levels of NF-κB-related mediators (i.e., iNOS, TNF-α, and IL-1β) and Nrf2-related antioxidants (i.e., NQO1 and HO-1) were significantly lower in the Nrf2 KO group regardless of E2 treatment compared to the WT. The expression of estrogen receptor beta (ERβ) was higher in the Nrf2 KO group than in the WT. In conclusion, estrogen further inhibits CRC by upregulating ERβ-related alternate pathways in the absence of Nrf2.

Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex.

Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required