Increased lung volume in infants and toddlers at high compared to low altitude

Children and adults residing at high altitude (HA) compared to low altitude (LA) have larger lung volumes; however, it is unknown whether this response to chronic hypoxia begins early in life. Our objective was to determine whether infants and toddlers at HA have larger lung volumes compared to infants and toddlers at LA. Oxygen saturation (SaO2 ), functional residual capacity (FRC), as well as serum levels of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) were measured in infants and toddlers from HA (N = 50; 3,440 m) and LA (N = 35; 440 m). There were no significant differences in somatic size for HA and LA subjects; however, HA subjects had significantly lower SaO2 (88.5% vs. 96.7%; P < 0.0001). Subjects at HA had significantly greater FRC compared to subjects at LA (group mean: 209 and 157 ml; P < 0.0001), adjusting for body length. Male infants at HA had a significantly greater FRC compared to males at LA (57 ml; P-value < 0.001); however, the increase in FRC for females at HA compared to LA was not significant (20 ml; P-value = 0.101). VEGF and EPO were significantly higher for subjects at HA compared to LA with no gender differences. In summary, infants and toddlers at HA have lower oxygen saturations, higher serum levels of VEGF and EPO, and higher FRC compared to subjects at LA; however, chronic hypoxia appears to generate a more robust response in lung growth in male compared to female infants early in life

CD100 up-Regulation Induced by Interferon-α on B Cells Is Related to Hepatitis C Virus Infection

Objectives: CD100, also known as Sema4D, is a member of the semaphorin family and has important regulatory functions that promote immune cell activation and responses. The role of CD100 expression on B cells in immune regulation during chronic hepatitis C virus (HCV) infection remains unclear. Materials and Methods: We longitudinally investigated the altered expression of CD100, its receptor CD72, and other activation markers CD69 and CD86 on B cells in 20 chronic HCV-infected patients before and after treatment with pegylated interferon-alpha (Peg-IFN-α) and ribavirin (RBV) by flow cytometry. Results: The frequency of CD5+ B cells as well as the expression levels of CD100, CD69 and CD86 was significantly increased in chronic HCV patients and returned to normal in patients with sustained virological response after discontinuation of IFN-α/RBV therapy. Upon IFN-α treatment, CD100 expression on B cells and the two subsets was further up-regulated in patients who achieved early virological response, and this was confirmed by in vitro experiments. Moreover, the increased CD100 expression via IFN-α was inversely correlated with the decline of the HCV-RNA titer during early-phase treatment. Conclusions: Peripheral B cells show an activated phenotype during chronic HCV infection. Moreover, IFN-α therapy facilitates the reversion of disrupted B cell homeostasis, and up-regulated expression of CD100 may be indirectly related to HCV clearance

State funded places in independent day schools before 1976

Transfection efficiency of Ad-A20 and Ad-ABIN1. Transfection efficiencies were determined using signals of GFP co-expression from Ad-A20 and Ad-ABIN1 vectors. The efficiencies were approximately > 90 %. (TIFF 2031 kb

Coping Mediates the Association Between Type D Personality and Perceived Health in Chinese Patients with Coronary Heart Disease

Background: Increasing evidence show that Type D personality is a risk factor for morbidity, mortality, and quality of life of patients with coronary vascular disease. Few studies examined coping as a potential behavioral mechanism to explain the harmful effect of Type D personality. Purpose: This study examined the association between Type D personality, coping, and perceived health among Chinese patients with coronary heart disease (CHD). Methods: One hundred seventeen CHD patients completed the assessments on Type D personality, coping, perceived severity of CHD, and morale. Results: There was no difference on severity of coronary artery stenosis between Type D and non-Type D patients. Compared to the non-Type D patients, the Type D patients perceived higher severity of CHD (5.31±2.41 versus 4.45±2.17, p<0.05) and lower morale (12.67±4.71 versus 15.00±4.43, p<0.05), and used less confrontation (16.90±5.39 versus 20.88±4.95, p<0.001) and more acceptance-resignation coping (10.16±3.50 versus 8.35±3.48, p<0.05). Mediation analyses showed that confrontation coping mediated the association between Type D personality and perceived severity of disease, and acceptance-resignation coping mediated the association between Type D personality and morale after controlling for age, gender, and clinical variables. Conclusion: The Type D patients used maladaptive coping in response to disease. These coping strategies fully mediated the association between Type D personality and perceived health. Implications for integrating coping training into the intervention for patients with a Type D personality are discussed. © 2010 The Author(s).published_or_final_versionSpringer Open Choice, 21 Feb 201

Influence of the axial position of the external load on the mechanical behavior of the bolted lap joint with different materials

The axial mechanical behaviors of the bolted joint are a primary concern of the bolted joint structures. The axial load position has obvious influence on the axial mechanical behaviors of the bolted joint with different materials, while it can not be considered by the analytical method yet. The objective of this work is to fill this gap. With the pressure cone assumption, the axial resilience of the stress zones is derived, and the detailed formulation of the load introduction factor is proposed. The mechanical behavior of the bolted joint subjected to external axial load is formulated and compared with finite element analysis. Results show that the distance between load planes has apparent influence on the axial mechanical behaviors of the bolted joint. In particular for the bolted joint with different materials, the axial positions of the external load have obvious effect on the mechanical behavior. Comparisons with the finite element results indicate that with the proposed formulation of load introduction factor, the analytical formulations could predict the mechanical behavior of the bolted joint with different materials accurately. The proposed formulation of load introduction factor in this work could be an effective supplement of the heavy duty bolt design guideline

Establishment of Approximate Analytical Model of Oil Film Force for Finite Length Tilting Pad Journal Bearings

Tilting pad bearings offer unique dynamic stability enabling successful deployment of high-speed rotating machinery. The model of dynamic stiffness, damping, and added mass coefficients is often used for rotordynamic analyses, and this method does not suffice to describe the dynamic behaviour due to the nonlinear effects of oil film force under larger shaft vibration or vertical rotor conditions. The objective of this paper is to present a nonlinear oil force model for finite length tilting pad journal bearings. An approximate analytic oil film force model was established by analysing the dynamic characteristic of oil film of a single pad journal bearing using variable separation method under the dynamic π oil film boundary condition. And an oil film force model of a four-tilting-pad journal bearing was established by using the pad assembly technique and considering pad tilting angle. The validity of the model established was proved by analyzing the distribution of oil film pressure and the locus of journal centre for tilting pad journal bearings and by comparing the model established in this paper with the model established using finite difference method

A Numerical Study for Flow Excitation and Performance of Rampressor Inlet considering Rotor Motion

A unique supersonic compressor rotor with high pressure ratio, termed the Rampressor, is presented by Ramgen Power Systems, Inc. (RPS). In order to obtain the excitation characteristic and performance of Rampressor inlet flow field under external excitation, compression inlet flow of Rampressor is studied with considering Rampressor rotor whirling. Flow excitation characteristics and performance of Rampressor inlet are analyzed under different frequency and amplitude of Rampressor rotor whirling. The results indicate that the rotor whirling has a significant effect for flow excitation characteristics and performance of Rampressor inlet. The effect of rotor whirling on the different inlet location excitation has a definite phase difference. Inlet excitation becomes more complex along with the inlet flow path. More frequency components appear in the excitation spectrum of Rampressor inlet with considering Rampressor rotor whirling. The main frequency component is the fundamental frequency, which is caused by the rotor whirling. Besides the fundamental frequency, the double frequency components are generated due to the coupling between inlet compression flow of Rampressor rotor and rotor whirling, especially in the subsonic diffuser of Rampressor rotor inlet. With the increment of rotor whirling frequency and whirling amplitude, the complexity of Rampressor inlet excitation increases, and the stability of Rampressor inlet performance deteriorates

Experimental Study on Fault Caused by Partial Arc Steam Forces and Its Economic Solution

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