Highly efficient synthesis of LTA-type aluminophosphate molecular sieve by improved ionothermal method

This work was supported by the National Natural Science Foundation of China (Grant No. 21306072, 21203081) and Development Program of Lanzhou University of Technology for excellent teachers (Grant No. Q201113). WZ thanks EPSRC for financial support to upgrade the SEM facilities (No. EP/F019580/1). We cordially thank the Reviewers and Editors for providing us with valuable comments and suggestions.LTA-type aluminophosphate molecular sieve has been successfully synthesized by improvedionothermal method from a gel containing low-dosage ionic liquids. The optimum syntheticconditions of this material are refined. The resultant LTA molecular sieves were characterized byXRD, SEM, TG-DTA, CHN elemental analysis, solution 13C NMR, EDX, TEM and N2physisorption. The composition of the resulting LTA-type molecular sieves is determined to be(Al12P12O48)(C4H9NO)2(C8H15N2+)2(F-)2, for which morpholine together with1-butyl-3-methylimidazolium cations act as the structure-directing agent. The high zeolite yield, as well as the high specific surface area and micropore volume for the calcined LTA-type materials imply that these zeolitic materials have a high potential in applications.PostprintPeer reviewe

Fast determination of polybrominated diphenyl ethers residues in milk by dispersive solid phase extraction and isotope labeled internal standard-gas chromatography-tandem mass spectrometry

Objective A 13C isotope labeled internal standard-gas chromatography-tandem mass spectrometric (GC-MS/MS) with dispersive solid phase extraction (d-SPE) method was developed for the simultaneous determination of 7 polybrominated diphenyl ethers (PBDEs) residues in milk. Methods After adding13C12 isotope internal standard and extracted with 1% acetic acid acetonitrile, purified with the new Z-Sep+C18 dispersive agent, the analytes in the sample solutions were seperated by DB-5 column (30 m×0.25 mm, 0.25 μm). Operated by electron impact ion source (EI) with multiple reactions monitoring (MRM) mode, the samples were analyzed by gas chromatography-tandem mass spectrometer. The quantifications were performed by the isotope internal standard method with matrix-matched calibration standards. Results Good linearity was obtained for 7 PBDEs in the concentration range of 0.500-100 ng/mL with correlation coefficients (r) above 0.999. Recoveries for 7 PBDEs at three spiked levels of 0.1, 1.0, and 10 μg/kg were in the range of 89.7%-102.9% with relative standard deviations (RSDs, n = 6) of 3.8%-8.3%. The limits of detection and the limits of quantification were in the ranges of 2.4-9.8 and 7.5-30 ng/kg, respectively. Conclusion The established method was simple, efficient and sensitive, and could be applied in the determination of 7 PBDEs in milk

Contents of Organochlorine Pesticides in Water , Pore Water and Sediment in Minjiang River Estuary of China

[摘要]：利用GC2ECD 和GC2MSD 对1999 年11 月闽江口水、间隙水和沉积物中的有机氯农药进行了研究. 结果显 示,闽江口水中有机氯农药的含量范围是01532～1182μg/ L ,间隙水中有机氯农药的含量为4154～1317μg/ L ,沉 积物(干重,以下讨论到的沉积物,无特别说明都是干重表示) :28179～52107μg/ kg ;与其他河口如珠江口、九龙江 口相比,闽江口的污染水平居中. 间隙水的污染物浓度普遍高于其上覆水的浓度,而沉积物中的浓度大于间隙水、 表层水,是由于有机污染物在水体中倾向于吸附在沉积物颗粒,并且通过再悬浮从底层向上迁移. 对水体中有机 氯农药各组分的含量及特征进行了分析,发现有机氯农药的主成分为:β2HCH ,DDE ,Heptachlor (七氯) ,Endosulfan Ⅱ(硫丹) ,Methoxychlor (甲氧滴涕) . DDE、β2HCH、Endosulfan Ⅱ分别占DDTs、HCHs 和硫丹的主要部分;有机氯 农药各组分间有正相关性,表明其河口有机氯农药陆源的土壤输入与相似的环境行为;对该河口的污染水平进行 了初步的评价,HCHs 符合国家海水水质一级标准,DDTs 则超过该标准.[Abstract]:The concentrations of 18 organochlorine pesticedes in water , pore water and surface sediment from Minjiang River Estuary were analyzed by GC2ECD , and confirmed by GC2MSD. The range of organochlorine pesticides was 01532～1182μg/ L at water , 4154～1317μg/ L at pore water , and 28179～52107μg/ kg at sediment . Compared with the results of other estuaries and gulfs (Pearl River Estuary , Jiulong River Estuary and so on) , it showed that the pollu2 tion of organochlorines in Minjiang was some moderate. The concentration difference in surface water , middle water , bottom water , pore water and sediment , due to the higher affinity of these hydrophobic compound for sedimentary phase than to water and a potential flux of pollutants from sediment to overlying water. The predominance ofβ2HCH ,DDE , Heptachlor , Endosulfan Ⅱand Methoxychlor in all water , pore water and sediment were clearly observed. On average , DDE、β2HCH、Endosulfan Ⅱoccupied the most part of total DDTs , HCHs and Endosulfans respectively , indicated the fate of these parent compounds or congeners. At the same time , it was found that thepositive relationship among the in2 dividual organochlorine components (HCHs , DDTs and Endosulfans) , which indicated that the similar of the source and behavior for organochlorine pesticides.海洋环境科学教育部重点实验室开放基金与教育 部重点基金联合资

Effectiveness of intravenous r-tPA versus UK for acute ischaemic stroke: a nationwide prospective Chinese registry study

BACKGROUND Intravenous recombinant tissue plasminogen activator (r-tPA) and urokinase (UK) are both recommended for the treatment of acute ischaemic stroke (AIS) in China, but with few comparative outcome data being available. We aimed to compare the outcomes of these two thrombolytic agents for the treatment of patients within 4.5 hours of onset of AIS in routine clinical practice in China. METHODS A pre-planned, prospective, nationwide, multicentre, real-world registry of consecutive patients with AIS (age ≥18 years) who received r-tPA or UK within 4.5 hours of symptom onset according to local decision-making and guideline recommendations during 2017-2019. The primary effectiveness outcome was the proportion of patients with an excellent functional outcome (defined by modified Rankin scale scores 0 to 1) at 90 days. The key safety endpoint was symptomatic intracranial haemorrhage according to standard definitions. Multivariable logistic regression was used for comparative analysis, with adjustment according to propensity scores to ensure balance in baseline characteristics. RESULTS Overall, 4130 patients with AIS were registered but 320 had incomplete or missing data, leaving 3810 with available data for analysis of whom 2666 received r-tPA (median dose 0.88 (IQR 0.78-0.90) mg/kg) and 1144 received UK (1.71 (1.43-2.00)×10 international unit per kilogram). There were several significant intergroup differences in patient characteristics: r-tPA patients were more educated, had less history of stroke, lower systolic blood pressure, greater neurological impairment and shorter treatment times from symptom onset than UK patients. However, in adjusted analysis, the frequency of excellent outcome (OR 1.18, 95% CI 1.00 to 1.40, p=0.052) and symptomatic intracranial haemorrhage (OR 0.70, 95% CI 0.33 to 1.47, p=0.344) were similar between groups. CONCLUSIONS UK may be as effective and carry a similar safety profile as r-tPA in treating mild to moderate AIS within guidelines in China. REGISTRATION: http://www.clinicaltrials.gov. unique identifier: NCT02854592