Detection of Lead in the Carbon-Rich, Very Metal-Poor Star LP625-44: A Strong Constraint on s-Process Nucleosynthesis at Low Metallicity

We report the detection of the Pb I 4057.8A line in the very metal-poor ([Fe/H]=-2.7), carbon-rich star, LP625-44. We determine the abundance of Pb ([Pb/Fe] = 2.65) and 15 other neutron-capture elements. The abundance pattern between Ba and Pb agrees well with a scaled solar system s-process component, while the lighter elements (Sr-Zr) are less abundant than Ba. The enhancement of s-process elements is interpreted as a result of mass transfer in a binary system from a previous AGB companion, an interpretation strongly supported by radial velocity variations of this system. The detection of Pb makes it possible, for the first time, to compare model predictions of s-process nucleosynthesis in AGB stars with observations of elements between Sr and Pb. The Pb abundance is significantly lower than the prediction of recent models (e.g., Gallino et al. 1998), which succeeded in explaining the metallicity dependence of the abundance ratios of light s-elements (Sr-Zr) to heavy ones (Ba-Dy) found in previously observed s-process-enhanced stars. This suggests that one should either (a) reconsider the underlying assumptions concerning the 13C-rich s-processing site (13C-pocket) in the present models, or (b) investigate alternative sites of s-process nucleosynthesis in very metal-poor AGB stars.Comment: 10 pages, 3 figures, Astrophysical Journal Letters, in pres

Immunoregulatory soluble CTLA-4 modifies effector T cell responses in systemic lupus erythematosus

Acknowledgments This work was supported by Arthritis Research UK (Grant no. 19282). We are grateful to Dr. Nick Fluck for his invaluable support in recruiting patients for the study, and Mrs. Vivien Vaughan for her invaluable expertise in recruiting study participants and maintaining ethical documentation.Peer reviewedPublisher PD

Generalized β\beta-conformal change and special Finsler spaces

In this paper, we investigate the change of Finslr metrics $$L(x,y) \to\bar{L}(x,y) = f(e^{\sigma(x)}L(x,y),\beta(x,y)),$$ which we refer to as a generalized $\beta$-conformal change. Under this change, we study some special Finsler spaces, namely, quasi C-reducible, semi C-reducible, C-reducible, $C_2$-like, $S_3$-like and $S_4$-like Finsler spaces. We also obtain the transformation of the T-tensor under this change and study some interesting special cases. We then impose a certain condition on the generalized $\beta$-conformal change, which we call the b-condition, and investigate the geometric consequences of such condition. Finally, we give the conditions under which a generalized $\beta$-conformal change is projective and generalize some known results in the literature.Comment: References added, some modifications are performed, LateX file, 24 page

Analysis of TerraSAR-X data and their sensitivity to soil surface parameters over bare agricultural fields

International audienceCette recherche a pour objectif de mettre en évidence la contribution des capteurs haute résolution pour une meilleure caractérisation de la surface du sol et pour analyser les effets de la polarisation et de l'angle d'incidence radar. L'objectif de cet article est d'analyser la sensibilité des données haute résolution Terrassar-X sur des sols sans couverture végétale et d'étudier la variabilité spatiale. Les relations entre le coefficient de rétrodiffusion et les paramètres du sol seront étudiés grâce aux images (TerraSAR, Ikonos, SPOT) ainsi que grâce aux mesures de terrain recueillies pendant plusieurs campagnes de terrain en hiver et printemps 2008-2009. Ce travail a été mené sur le bassin de l'Orgeval (France). / Our research aims to show the contribution of high resolution spatial sensors for a better characterization of soil surface, and to analyze polarization effects and radar incidence angle. The objective of this paper is to analyze the sensitivity of very high resolution TerraSAR-X radar data taken over bare soils, and to study the spatial variability. The relationship between backscattering coefficient and soil's parameters (moisture, surface roughness, and texture) will be examined by means of satellite images (TerraSAR, Ikonos, SPOT), as well as ground truth measurements, recorded during several field campaigns in the winter and spring of 2008 and 2009. This study is carried out on Orgeval catchment (France)

Optimizing the magnon-phonon cooperativity in planar geometries

Optimizing the cooperativity between two distinct particles is an important feature of quantum information processing. Of particular interest is the coupling between spin and phonon, which allows for integrated long range communication between gates operating at GHz frequency. Using local light scattering, we show that, in magnetic planar geometries, this attribute can be tuned by adjusting the orientation and strength of an external magnetic field. The coupling strength is enhanced by about a factor of 2 for the out-of-plane magnetized geometry where the Kittel mode is coupled to circularly polarized phonons, compared to the in-plane one where it couples to linearly polarized phonons. We also show that the overlap between magnon and phonon is maximized by matching the Kittel frequency with an acoustic resonance that satisfies the half-wave plate condition across the magnetic film thickness. Taking the frequency dependence of the damping into account, a maximum cooperativity of about 6 is reached in garnets for the normal configuration near 5.5 GHz

On Finslerized Absolute Parallelism spaces

The aim of the present paper is to construct and investigate a Finsler structure within the framework of a Generalized Absolute Parallelism space (GAP-space). The Finsler structure is obtained from the vector fields forming the parallelization of the GAP-space. The resulting space, which we refer to as a Finslerized Parallelizable space, combines within its geometric structure the simplicity of GAP-geometry and the richness of Finsler geometry, hence is potentially more suitable for applications and especially for describing physical phenomena. A study of the geometry of the two structures and their interrelation is carried out. Five connections are introduced and their torsion and curvature tensors derived. Some special Finslerized Parallelizable spaces are singled out. One of the main reasons to introduce this new space is that both Absolute Parallelism and Finsler geometries have proved effective in the formulation of physical theories, so it is worthy to try to build a more general geometric structure that would share the benefits of both geometries.Comment: Some references added and others removed, PACS2010, Typos corrected, Amendemrnts and revisions performe

On dimension reduction in Gaussian filters

A priori dimension reduction is a widely adopted technique for reducing the computational complexity of stationary inverse problems. In this setting, the solution of an inverse problem is parameterized by a low-dimensional basis that is often obtained from the truncated Karhunen-Loeve expansion of the prior distribution. For high-dimensional inverse problems equipped with smoothing priors, this technique can lead to drastic reductions in parameter dimension and significant computational savings. In this paper, we extend the concept of a priori dimension reduction to non-stationary inverse problems, in which the goal is to sequentially infer the state of a dynamical system. Our approach proceeds in an offline-online fashion. We first identify a low-dimensional subspace in the state space before solving the inverse problem (the offline phase), using either the method of "snapshots" or regularized covariance estimation. Then this subspace is used to reduce the computational complexity of various filtering algorithms - including the Kalman filter, extended Kalman filter, and ensemble Kalman filter - within a novel subspace-constrained Bayesian prediction-and-update procedure (the online phase). We demonstrate the performance of our new dimension reduction approach on various numerical examples. In some test cases, our approach reduces the dimensionality of the original problem by orders of magnitude and yields up to two orders of magnitude in computational savings

Consistency, Amplitudes and Probabilities in Quantum Theory

Quantum theory is formulated as the only consistent way to manipulate probability amplitudes. The crucial ingredient is a consistency constraint: if there are two different ways to compute an amplitude the two answers must agree. This constraint is expressed in the form of functional equations the solution of which leads to the usual sum and product rules for amplitudes. A consequence is that the Schrodinger equation must be linear: non-linear variants of quantum mechanics are inconsistent. The physical interpretation of the theory is given in terms of a single natural rule. This rule, which does not itself involve probabilities, is used to obtain a proof of Born's statistical postulate. Thus, consistency leads to indeterminism. PACS: 03.65.Bz, 03.65.Ca.Comment: 23 pages, 3 figures (old version did not include the figures

Lorentz-violating vs ghost gravitons: the example of Weyl gravity

We show that the ghost degrees of freedom of Einstein gravity with a Weyl term can be eliminated by a simple mechanism that invokes local Lorentz symmetry breaking. We demonstrate how the mechanism works in a cosmological setting. The presence of the Weyl term forces a redefinition of the quantum vacuum state of the tensor perturbations. As a consequence the amplitude of their spectrum blows up when the Lorentz-violating scale becomes comparable to the Hubble radius. Such a behaviour is in sharp contrast to what happens in standard Weyl gravity where the gravitational ghosts smoothly damp out the spectrum of primordial gravitational waves.Comment: 14 pages, 3 figures, REVTeX 4.

The presence of Y674/Y675 phosphorylated NTRK1 via TP53 repression of PTPN6 expression as a potential prognostic marker in neuroblastoma

The tumor suppressor TP53 promotes nerve growth factor receptor (NTRK1) -Y674/Y675 phosphorylation (NTRK1-pY674/pY675) via repression of the NTRK1 phosphatase PTPN6 in a ligand-independent manner, resulting in suppression of breast cancer cell proliferation. Moreover, NTRK1-pY674/pY675 together with low levels of PTPN6 and TP53 expression is associated with favorable disease-free survival of breast cancer patients. We determined whether in neuroblastoma this protein expression pattern impacts relapse-free survival (RFS). NTRK1-pY674/pY675, PTPN6, and TP53 expression was assessed in 98 neuroblastoma samples by immunohistochemistry. Association between expression levels and RFS was investigated by multivariate and Kaplan-Meier analysis. Mutant or wild-type TP53 was identified by sequencing tumor DNA. Tumors expressing NTRK1-pY674/pY675 and low or undetectable levels of PTPN6 and TP53 were significantly associated with 5-year RFS (P = .014) when the dataset was stratified by MYCN amplification, segmental chromosomal abnormalities and histology. Similar results were observed with tumors expressing wild-type TP53, NTRK1-pY674/pY675 and low or undetectable levels of PTPN6. Kaplan-Meier analysis demonstrated a significant correlation (P = .004), with a 50% probability of RFS (median survival 4.73 years) when present compared with 19.51% (median survival 11.63 months) when absent. Similar results were seen with non-amplified MYCN or unfavorable/undifferentiating samples and tumors from patients aged 18 months or less. Importantly, NTRK1-pY674/pY675 is an independent predictor of improved RFS. These results strongly suggest that NTRK1-pY674/pY675 together with wild-type TP53 and undetectable or low levels of PTPN6 expression is a potential biomarker of improved RFS of neuroblastoma patients. The predictive value of NTRK1-pY674/pY675 together with wild-type TP53 and low PTPN6 expression could contribute to neuroblastoma patient prognosis