Shifting Identity/ies in the Literature of Arab Immigration and Exile: Hanan Al-Shaykh’s Hikayat Zahra (The Story of Zahra) as a Case Study

In this age of mass migration, refugee crises, and global mobility, it could be argued that the experience of displacement, relocation, migration, and diaspora is no longer the exception but the rule. The tension between the centre and the periphery, the ‘homeland’ and the ‘host land’ raises, time and again, familiar issues of belonging, allegiance, affinity, estrangement and alienation. It is on this perspective- following various paths among which the postcolonial theory- that the aim of this paper is to try to shed light, and more precisely on the notion of “shifting identity/ies”/concepts of identity and difference based on Hanan Al-Shaykh’s  Hikayat Zahra/The Story of Zahra .This paper hopes to answer the following question raised in the novel “Does the émigré become abnormal once he has departed his own land?” Keywords : migration-global- diaspora-postcolonial theory-identity-shifting-alienation DOI: 10.7176/JLLL/92-02 Publication date:October 31st 202

Semiotic Analysis of Facebook Video Ads: The Case of Renault Kadjar

The present paper seeks to analyse a Renault Kadjar video advertisement launched on Facebook. It argues that with the widespread use of new technologies, electronic gadgets, and social media, clearly-demarcated boundaries between disciplines can no longer be pinned down. While in this paper we assert that conducting a study that pertains to digital culture and marketing is a daunting task since Human Sciences ( HS) are intermingled with various disciplines and fields of study, namely art, cinema, and new media, to mention but a few, this work  tries to bring  to the fore that the research methodology adopted which goes beyond Critical Discourse Analysis to image and video analysis helps solve this issue. In this respect, the results revealed that images, verbal, non-verbal elements deployed to persuade prospect clients are fluid and unstable because of the dynamic interplay between (PICM) Presentational, Interactive, and Compositional Meaning. Keywords— New media; Video Ad ; dynamic interplay; visual grammar; PICM. DOI: 10.7176/NMMC/105-04 Publication date:November 30th 202

Isolation, purification and characterization of phytase from Bacillus subtilis MJA

In this study, three strains of bacteria were isolated from soil. Among the three isolated strains, one was identified morphologically and confirmed by the molecular techniques as Bacillus subtilis MJA with high phytase activity. The phytase-producing bacteria were isolated using phytate screening agar media (PSM) with only 1.5% glucose and 0.5% sodium phytate as only source for carbon. In order to optimize the phytase production by B. subtilis MJA, different factors were studied. A combination of 0.5% glucose and 0.5% sucrose showed to be the best carbon source. Also, malt extract used as a source of nitrogen gave the highest phytase production. Also, the maximum phytase production was detected after incubation for four days (720 U/ml) at an optimum pH value of 7. The produced phytase was purified through various chromatographic techniques. The estimated enzyme molecular mass was about 38 kDa and the phytase had an optimal temperature and pH of 37°C and 5 to 6, respectively. On the other hand, studying the enzyme stability showed that enzyme was stable at low temperature, and had good pH stability by retaining 80% of its initial activity over a wide range of pH from 2 to 8. Kinetic values of Vmax and Km for the purified enzyme were 510 U/mg and 0.485 mM, respectively. The phytase activity was affected by different divalent metal ions. Cations such as Cu2+ or Fe2+ showed an inhibition effect on the phytase activity and the effect was in a dose dependent manner while, cations such as Mg2+ or Ca2+ showed an increase in the phytase activity. On the other hand, among different matricesused to immobilize the cells for phytase production, agar-agar matrix indicated a promising immobilization matrix used for phytase production by B. subtilis MJA.Keywords: Phytase, microbial sources, optimization, purification, characterization, immobilizationAfrican Journal of BiotechnologyVol. 12(20), pp. 2957-296

BlockCampus: A Blockchain-Based DApp for enhancing Student Engagement and Reward Mechanisms in an Academic Community for E-JUST University

In today's digital age, online communities have become an integral part of our lives, fostering collaboration, knowledge sharing, and community engagement. Higher education institutions, in particular, can greatly benefit from dedicated platforms that facilitate academic discussions and provide incentives for active participation. This research paper presents a comprehensive study and implementation of a decentralized application (DApp) leveraging the blockchain technology to address these needs specifically for E-JUST (Egypt-Japan University of Science and Technology) students and academic staff

FLT3 receptor/CD135 expression by flow cytometry in acute myeloid leukemia: Relation to FLT3 gene mutations and mRNA transcripts

Background: Alterations of the FLT3 gene are the most frequent molecular aberrations seen at diagnosis of acute myeloid leukemia (AML). Two main types of FLT3 mutations have been the most commonly detected; internal tandem duplication (ITD) in the juxtamembrane domain and point mutation D835Y in the tyrosine kinase domain (TKD). Both classes of mutations result in constitutive activation of FLT3 receptor/CD135.Aim: To assess the frequency of FLT3 gene mutations (ITD and TKD D835Y) and the flow cytometric expression of FLT3 receptor/CD135 among AML patients to define the role for FLT3 receptor expression in predicting FLT3 gene mutational status and mRNA transcript level.Subjects and methods: Eighty AML patients at diagnosis and 20 control subjects were enrolled. FLT3 receptor/ CD135 expression, FLT3 gene mutations, and FLT3 transcript level were evaluated by flow cytometry, conventional polymerase chain reaction (PCR), and quantitative real-time reverse-transcription PCR, respectively. Fluorescence in situ hybridization was done to stratify patients into favorable, intermediate, and poor cytogenetic risk groups.Results: FLT3-ITD was detected in 22.5% AML patients, while none had FLT3-TKD D835Y mutation. A cutoff value of >17% was assigned to define FLT3 receptor/CD135+ cases. FLT3 receptor/CD135 and FLT3 transcripts were overexpressed in 100% AML patients; higher levels were found among AML-M5 subtype and poor cytogenetic group. AML patients harboring FLT3-ITD showed a trend for higher FLT3 receptor/CD135 expression and FLT3 transcript level than those with wild-type FLT3. FLT3 receptor/CD135 >49% was predictive for FLT3-ITD. A positive correlation was found between FLT3 receptor/CD135 expression and FLT3 transcript level.Conclusion: Evaluation of FLT3 receptor/CD135 expression by flow cytometry at diagnosis of AML could constitute a predictor for the FLT3-ITD mutational status and FLT3 transcript level.Keywords: Acute myeloid leukemia, CD135, FLT3 receptor, FLT3 mRNA, FLT3-ITD, FLT3-TK

Evaluation of the Predictive value of C-reactive Protein, Interleukin-6 and their derived immune-inflammatory indices in COVID-19 Egyptian patients

Background: In coronavirus disease 2019 (COVID-19), finding sensitive biomarkers is critical for detecting severe cases early and intervening effectively. Aim of the work:  To compare and evaluate the value of pretreatment c-reactive protein (CRP), interleukin-6 (IL-6), and their derived immune-inflammatory indices (CRP/albumin (CRP/alb), lymphocyte/CRP (L/CRP), and lymphocyte/IL-6 (L/IL-6)) in the prediction of COVID-19 severity and in-hospital mortality. Methods: This cross-sectional study included 85 confirmed COVID-19 patients, their complete blood count with differential, as well as albumin and IL-6 levels on the day of their hospital admission, were assessed and compared. We followed all patients till their in-hospital death or discharge from the hospital. Results: On admission levels of CRP, IL-6, and CRP/alb were significantly higher (p < /em>=0.001) in severe patients and non-survivors, but L/CRP and L/IL-6 were significantly lower (p < /em>=0.001) compared to non-severe patients and non-survivors. CRP/alb and L/CRP at cut-offs of 1.65 and 260.86, respectively, were the best predictors for COVID-19 severity, while IL-6 and L/IL-6 at cut-offs of 120 pg/ml and 5.40, respectively, were the best predictors for COVID-19 in-hospital mortality. IL-6 was an independent risk factor associated with severe disease development (odds ratio (OR): 1.033; 95% confidence interval (CI): 1.002-1.066). Conclusions: Pretreatment levels of CRP, IL-6, and their derived indices should be included in the diagnostic work-up of COVID-19 to determine the severity and predict the outcome

Perception of Biostatistics by Lebanese Medical Students: A Cross-Sectional Study

Background: Inadequate use of statistics in biomedical research might not only affect science but also harm human beings if applied in medical practice. Biostatistics is fundamental to improve understanding and appraising of evidence-based medicine (EBM); yet, it is still not well understood and appreciated by medical students. Therefore, early exposure of medical students and physicians-in-training to research tools including Biostatistics is of utmostimportance.Objective: The aim of this study is to determine the perception of Biostatistics by medical students at a private medical school in Beirut, Lebanon, and to identify its best implementation time in the medical curriculum.Methods: This is a cross-sectional study based on a self-administered questionnaire distributed among medical students in their pre-clerkship years (first three years of a 6-year program) who undertook Biostatistics. The assessment of perception was based on the 5-point Likert scale anchored by Strongly disagree = 1 and Strongly agree = 5 including 36 questions distributed into four domains to assess the course value, difficulty, behavioral, and expectations.Results: 186 of 269 students responded to the questionnaire, yielding a response rate of 69.14%. Around 60% of students declared that the knowledge gained from biostatistics courses is useful to their future career, and almost 70% understood the main concepts of biostatistics. 57.7% of students perceived that lack of practicing exercises might contribute to making the course more difficult. The mean score of domains was higher in females but did not significantly differ within the three academic years. Only 35.1% of the students positively perceived the importance of biostatistics modules, mostly third-year students.Conclusion: Although the majority of medical students perceived biostatistics modules negatively, they were aware of the relevance of biostatistics to their medical career and real-life health issues

Postpartum Detection of Diastolic Dysfunction and Nondipping Blood Pressure Profile in Women With Preeclampsia

BACKGROUND: Left ventricular diastolic dysfunction and nocturnal nondipping of blood pressure detected via ambulatory blood pressure monitoring are predictors of increased cardiovascular morbidity. METHODS: A prospective cohort study including normotensive women with a history of preeclampsia in their current pregnancy was conducted. All cases were subjected to 24-hour ambulatory blood pressure monitoring and 2-dimensional transthoracic echocardiography 3 months after delivery. RESULTS: This study included 128 women with a mean (SD) age of 28.6 (5.1) years and a mean (SD) basal blood pressure of 123.1 (6.4)/74.6 (5.9) mm Hg. Among the participants, 90 (70.3%) exhibited an ambulatory blood pressure monitoring profile illustrating nocturnal blood pressure dipping (the mean night to day time blood pressure ratio ≤ 0.9), whereas 38 (29.7%) were nondippers. Diastolic dysfunction (impaired left ventricular relaxation) was present in 28 nondippers (73.7%), whereas none of the dippers exhibited diastolic dysfunction. Women with severe preeclampsia were more frequently nondippers (35.5% vs 24.2%; P = .02) and experienced diastolic dysfunction (29% vs 15%; P = .01) than were those with mild preeclampsia. Severe preeclampsia (odds ratio [OR], 1.08; 95% CI, 1.05-10.56; P \u3c .001) and history of recurrent preeclampsia (OR, 1.36; 95% CI, 1.3-4.26; P ≤ .001) were significant predictors for nondipping status and diastolic dysfunction (OR, 1.55; 95% CI, 1.1-2.2; and OR, 1.23; 95% CI, 1.2-2.2, respectively; P \u3c .05). CONCLUSION: Women with a history of preeclampsia were at higher risk for developing late cardiovascular events. The severity and recurrence of preeclampsia were significant predictors of both nondipping profile and diastolic dysfunction

Adult and paediatric mortality patterns in a referral hospital in Liberia 1 year after the end of the war

The aim of this study was to describe and analyse hospital mortality patterns after the Liberian war. Data were collected retrospectively from January to July 2005 in a referral hospital in Monrovia, Liberia. The overall fatality rate was 17.2% (438/2543) of medical admissions. One-third of deaths occurred in the first 24h. The adult fatality rate was 23.3% (241/1034). Non-infectious diseases accounted for 56% of the adult deaths. The main causes of death were meningitis (16%), stroke (14%) and heart failure (10%). Associated fatality rates were 48%, 54% and 31% respectively. The paediatric fatality rate was 13.1% (197/1509). Infectious diseases caused 66% of paediatric deaths. In infants <1 month old, the fatality rate was 18% and main causes of death were neonatal sepsis (47%), respiratory distress (24%) and prematurity (18%). The main causes of death in infants > or =1 month old were respiratory infections (27%), malaria (23%) and severe malnutrition (16%). Associated fatality rates were 12%, 10% and 19%. Fatality rates were similar to those found in other sub-Saharan countries without a previous conflict. Early deaths could decrease through recognition and early referral of severe cases from health centres to the hospital and through assessment and priority treatment of these patients at arrival

COVID-19 is associated with early emergence of preeclampsia: results from a large regional collaborative

Objective: To examine the relationship between COVID-19 and preeclampsia (PreE) in a large, diverse population. Study Design: The COVID-19 in Pregnancy and The Newborn: State of Michigan Collaborative established a database of pregnant patients admitted to 14 institutions in Southern Michigan. Patients with COVID-19 (cases) were matched to 2 or 3 non-COVID patients (controls) on the same unit within 30 days of each case. Relative Risks (RR) were calculated using robust Poisson regression models with adjustment for covariates. Chi-squared test for trend was used to assess the increase in risk with the severity of disease. Results: 369 cases and 1,090 controls were delivered between March - October 2020. An increased risk of PreE (RR=1.8), driven almost entirely by an increase in preterm PreE (pretermPreE) (RR=2.85) was observed in COVID pregnancies (Table 1), with a dose-response relationship with symptomatology and severity (Table 2). The associations between COVID-19 disease and PreE or pretermPreE were independent of other risk factors, as demonstrated by the minimal changes in RR after adjustment for confounders (Table 1). However, African American (AA) COVID patients experienced pretermPreE 1.9 times more than COVID patients of other races (10.1 vs 5.3), an increase not observed in control patients. The strength of the association for COVID with PreE was comparable to the association of PreE with chronic hypertension and nulliparity (data not shown). Increasing symptoms and severity of COVID-19 were associated with an increased risk for PreE with placental lesions, even after adjustment for relevant covariates (Tables 1 & 2). Non-PreE COVID patients had an increased trend of placental lesions compared to non-COVID patients, reaching significance for intravillous thrombin. Conclusion: COVID-19 is significantly associated with early emergence of PreE, independent of known risk factors other than AA race. Our study shows that among patients predisposed to PreE, COVID-19 impacts PreE severity in that it leads to pretermPreE. Further studies on COVID-19 and PreE, with a focus on racial disparities, is warranted