Working memory learning method and astrocytes number in different subfields of rat's Hippocampus

The aim of this study was evaluation of the astrocytes number in different subfields of rat's Hippocampus after spatial learning with usage of Morris Water Maze technique and working memory method. In this study, between 2005-2006 years in Pasteur institute of Iran-Tehran and histological department of Gorgan University with usage of Morris Water Maze and working memory technique, we used 14 male albino wistar rats. Seventh rats were in control group and 7 rats in working memory group. After histological preparation, the slides were stained with PTAH staining for showing the Astrocytes. Present results showed significant difference in astrocytes number in CA1, CA2 and CA3 areas of hippocampus between control and reference memory group. The number of astrocytes is increased in working memory group. Then we divided the hippocampus to three parts: Anterior, middle and posterior and with compare of different area (CA1, CA2 and CA3) of hippocampus, we found that the differences between Anterior-middle and Middle-Posterior of CA1 and CA2 area of hippocampus were significant, whereas the difference between Anterior-Posterior parts was not significant in CA1 and CA2 areas. In CA3 area, the difference between Anterior-Middle and Anterior-Posterior parts was significant, whereas the difference between middle and posterior parts was not significant. We concluded that the number of astrocytes increased due to spatial learning and working memory technique. © 2008 Science Publications

Feasibility of electron cyclotron autoresonance acceleration by a short terahertz pulse

A vacuum autoresonance accelerator scheme for electrons, which employs terahertz radiation and currently available magnetic fields, is suggested. Based on numerical simulations, parameter values, which could make the scheme experimentally feasible, are identified and discussed

Digital zero noise extrapolation for quantum error mitigation

Zero-noise extrapolation (ZNE) is an increasingly popular technique for mitigating errors in noisy quantum computations without using additional quantum resources. We review the fundamentals of ZNE and propose several improvements to noise scaling and extrapolation, the two key components in the technique. We introduce unitary folding and parameterized noise scaling. These are digital noise scaling frameworks, i.e. one can apply them using only gate-level access common to most quantum instruction sets. We also study different extrapolation methods, including a new adaptive protocol that uses a statistical inference framework. Benchmarks of our techniques show error reductions of 18X to 24X over non-mitigated circuits and demonstrate ZNE effectiveness at larger qubit numbers than have been tested previously. In addition to presenting new results, this work is a self-contained introduction to the practical use of ZNE by quantum programmers.Comment: 11 pages, 7 figure

High-quality multi-GeV electron bunches via cyclotron autoresonance

Autoresonance laser acceleration of electrons is theoretically investigated using circularly polarized focused Gaussian pulses. Many-particle simulations demonstrate feasibility of creating over 10-GeV electron bunches of ultra-high quality (relative energy spread of order 10^-4), suitable for fundamental high-energy particle physics research. The laser peak intensities and axial magnetic field strengths required are up to about 10^18 W/cm^2 (peak power ~10 PW) and 60 T, respectively. Gains exceeding 100 GeV are shown to be possible when weakly focused pulses from a 200-PW laser facility are used

Discourse analysis models in the training of translators : an emperical approach

Abstract unavailable please refer to PD

Electron and hole impact ionization coefficients in GaAs/Al0.45Ga0.55As/Al0.3Ga0.7As coupled well systems

We have measured electron and hole multiplication factors and impact ionization coefficients in 550 Å GaAs/500 Å Al0.3Ga0.7As quantum wells with an intermediate Al0.45Ga0.55As barrier (50 and 100 Å) inserted in the well region. It is seen that while the measured value of α(E) is insensitive to the position of the intermediate barrier in the well, the value of β(E) is very sensitive. The value of α/β varies from less than unity to 5, depending on the position of this barrier. These results suggest that hole confinement and scattering play a major role in making the value of α/β greater than unity in these multilayered structures.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70978/2/APPLAB-58-24-2791-1.pd

Embryonic anti-aging niche

Although functional organ stem cells persist in the old, tissue damage invariably overwhelms tissue repair, ultimately causing the demise of an organism. The poor performance of stem cells in an aged organ, such as skeletal muscle, is caused by the changes in regulatory pathways such as Notch, MAPK and TGF-β, where old differentiated tissue actually inhibits its own regeneration. This perspective analyzes the current literature on regulation of organ stem cells by their young versus old niches and suggests that determinants of healthy and prolonged life might be under a combinatorial control of cell cycle check point proteins and mitogens, which need to be tightly balanced in order to promote tissue regeneration without tumor formation. While responses of adult stem cells are regulated extrinsically and age-specifically, we put forward experimental evidence suggesting that embryonic cells have an intrinsic youthful barrier to aging and produce soluble pro-regenerative proteins that signal the MAPK pathway for rejuvenating myogenesis. Future identification of this activity will improve our understanding of embryonic versus adult regulation of tissue regeneration suggesting novel strategies for organ rejuvenation. Comprehensively, the current intersection of aging and stem cell science indicates that if the age-imposed decline in the regenerative capacity of stem cells was understood, the debilitating lack of organ maintenance in the old could be ameliorated and perhaps, even reversed

Video Quality Evaluation for Tile-Based Spatial Adaptation

The demand for very high-resolution video content in entertainment services (4K, 8K, panoramic, 360 VR) puts an increasing load on the distribution network. In order to reduce the network usage in existing delivery infrastructure for such services while keeping a good quality of experience, dynamic spatial video adaptation at the client side is seen as a key feature, and is actively investigated by academics and industrials. However, the impact of spatial adaptation on quality perception is not clear. In this paper, we propose a methodology for the evaluation of such adapted content, conduct a series of perceived quality measurements and discuss results showing potential benefits and drawbacks of the technique. Based on our results, we also propose a signaling mechanism in MPEGDASH to assist the client in its spatial adaptation log

Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae

<p>Abstract</p> <p>Background</p> <p>The human adenovirus type 5 early region 1A (E1A) gene encodes proteins that are potent regulators of transcription. E1A does not bind DNA directly, but is recruited to target promoters by the interaction with sequence specific DNA binding proteins. In mammalian systems, E1A has been shown to contain two regions that can independently induce transcription when fused to a heterologous DNA binding domain. When expressed in <it>Saccharomyces cerevisiae</it>, each of these regions of E1A also acts as a strong transcriptional activator. This allows yeast to be used as a model system to study mechanisms by which E1A stimulates transcription.</p> <p>Results</p> <p>Using 81 mutant yeast strains, we have evaluated the effect of deleting components of the ADA, COMPASS, CSR, INO80, ISW1, NuA3, NuA4, Mediator, PAF, RSC, SAGA, SAS, SLIK, SWI/SNF and SWR1 transcriptional regulatory complexes on E1A dependent transcription. In addition, we examined the role of histone H2B ubiquitylation by Rad6/Bre1 on transcriptional activation.</p> <p>Conclusion</p> <p>Our analysis indicates that the two activation domains of E1A function via distinct mechanisms, identify new factors regulating E1A dependent transcription and suggest that yeast can serve as a valid model system for at least some aspects of E1A function.</p