Insights into the first and second hydrostatic core stages from numerical simulations

The theory of how low mass stars form from the collapse of a dense molecular cloud core has been well-established for decades. Thanks to significant progress in computing and numerical modelling, more physical models have been developed and a wider parameter space explored to understand the early stages of star formation more fully. In this review, I describe the expected physical properties of the first and second core stages and how the inclusion of different physics affects those predicted characteristics. I provide an overview of chemical models and synthetic observations, looking towards the positive identification of the first core in nature, which remains elusive. However, there are a few likely candidate first cores, which are listed, and I briefly discuss the recent progress in characterising the youngest protostellar sources. Chemistry will be instrumental in the firm identification of the first core so we require robust theoretical predictions of the chemical evolution of protostellar cores, especially of the first and second core outflows. Looking ahead, simulations can shed light on how the protostellar collapse phase shapes the evolution of the protostellar disc. Simulations of dust evolution during protostellar core collapse show there is significant enhancement in grain size and abundance towards the centre of the core. Chemical models show that the warm, dense conditions of the first core drive chemical evolution. There is a wide scope for further study of the role that the first and second core stages play in determining the structure and composition of the protostellar disc and envelope and, of course, the eventual influence on the formation of planets

What can the SEDs of first hydrostatic core candidates reveal about their nature?

The first hydrostatic core (FHSC) is the first stable object to form in simulations of star formation. This stage has yet to be observed definitively, although several candidate FHSCs have been reported. We have produced synthetic spectral energy distributions (SEDs) from 3D hydrodynamical simulations of pre-stellar cores undergoing gravitational collapse for a variety of initial conditions. Variations in the initial rotation rate, radius and mass lead to differences in the location of the SED peak and far-infrared flux. Secondly, we attempt to fit the SEDs of five FHSC candidates from the literature and five newly identified FHSC candidates located in the Serpens South molecular cloud with simulated SEDs. The most promising FHSC candidates are fitted by a limited number of model SEDs with consistent properties, which suggests the SED can be useful for placing constraints on the age and rotation rate of the source. The sources we consider most likely to be in FHSC phase are B1-bN, CB17-MMS, Aqu-MM1 and Serpens South candidate K242. We were unable to fit SerpS-MM22, Per-Bolo 58 and Chamaeleon-MMS1 with reasonable parameters, which indicates that they are likely to be more evolved.Comment: 26 pages, 28 figures. Accepted for publication in MNRA

Characteristics of small protoplanetary disc warps in kinematic observations

Many circumstellar discs appear to have misaligned central regions that give rise to shadows seen in scattered light observations. Small warps ($<20^\circ$ misalignment) are probably more common but are also more difficult to detect than the large misalignments studied previously. We present the characteristics of CO emission that may be used to identify a small disc warp, found from synthetic $^{13}$CO maps of a model misaligned circumbinary disc. The spectra are not symmetrical, so fitting a Keplerian model is not appropriate and can hide a warp or lead to spurious features such as spirals appearing in the residuals. We quantify the observed warp structure by fitting sinusoids to concentric annuli of the disc. From this we can trace the radial variation of the peak velocity and of the azimuth of the peak velocity, i.e., the twist. At near face-on inclinations, these radial profiles reveal the warp structure. The twist remains detectable at moderate inclinations (${i_{\rm outer~disc}\lesssim 35^{\circ}}$) in the absence of radial flows but the measured inclination must be accurate to $\lesssim 5^{\circ}$ to allow detection of the radial variation. The observed twist does not provide a direct measure of the warp structure because of its dependence on optical depth. The warp causes broad asymmetries in the channel maps that span several channels and that are distinct from localised features caused by embedded planets and gravitational instability. We suspect that kinematic evidence of warps may have been missed and we suggest a few examples where the data may be revisited.Comment: 16 pages. Accepted to MNRA

On Visible Homelessness and the Micro-Aesthetics of Public Space

In this article, we investigate the circumstances that have produced the current municipal regulatory approach to homelessness in the City of Melbourne, Victoria, and the ways in which visibly homeless people are policed through a micro-aesthetics of their presence in public space, which involves the monitoring of their bodily demeanour and their physical possessions. Our study contributes to and draws from a range of debates, including studies of the governmental conjunction of poverty and crime, analysis of the co-implication of law and spatiality, research on the criminalisation of homelessness and homeless people, and the burgeoning criminological interest in the significance of the visual field for our understandings of crime and criminality. This article recounts how homelessness, public space and questions of aesthetics have recently coalesced in debates about the regulation of homelessness in the public space of Melbourne’s city centre. It approaches the issues through comparative consideration of genres of municipal management frameworks in other jurisdictions, detailed textual consideration of the Protocol on Homelessness in the City of Melbourne and an empirical study of visible homelessness in the public places of central Melbourne

Chemical signatures of a warped protoplanetary disc

Circumstellar discs may become warped or broken into distinct planes if there is a stellar or planetary companion with an orbit that is misaligned with respect to the disc. There is mounting observational evidence for protoplanetary discs with misaligned inner discs and warps that may be caused by such interactions with a previously undetected companion, giving us a tantalising indication of possible planets forming there. Hydrodynamical and radiative transfer models indicate that the temperature varies azimuthally in warped discs due to the variable angle at which the disc surface faces the star and this impacts the disc chemistry. We perform chemical modelling based on a hydrodynamical model of a protoplanetary disc with an embedded planet orbiting at a 12$^{\circ}$ inclination to the disc. Even for this small misalignment, abundances of species including CO and HCO$^+$ vary azimuthally and this results in detectable azimuthal variations in submillimetre line emission. Azimuthal variations in line emission may therefore indicate the presence of an unseen embedded companion. Nonaxisymmetric chemical abundances should be considered when interpreting molecular line maps of warped or shadowed protoplanetary discs.Comment: Accepted to MNRAS. 18 pages, 14 figure

RNA-seq: technical variability and sampling

<p>Abstract</p> <p>Background</p> <p>RNA-seq is revolutionizing the way we study transcriptomes. mRNA can be surveyed without prior knowledge of gene transcripts. Alternative splicing of transcript isoforms and the identification of previously unknown exons are being reported. Initial reports of differences in exon usage, and splicing between samples as well as quantitative differences among samples are beginning to surface. Biological variation has been reported to be larger than technical variation. In addition, technical variation has been reported to be in line with expectations due to random sampling. However, strategies for dealing with technical variation will differ depending on the magnitude. The size of technical variance, and the role of sampling are examined in this manuscript.</p> <p>Results</p> <p>In this study three independent Solexa/Illumina experiments containing technical replicates are analyzed. When coverage is low, large disagreements between technical replicates are apparent. Exon detection between technical replicates is highly variable when the coverage is less than 5 reads per nucleotide and estimates of gene expression are more likely to disagree when coverage is low. Although large disagreements in the estimates of expression are observed at all levels of coverage.</p> <p>Conclusions</p> <p>Technical variability is too high to ignore. Technical variability results in inconsistent detection of exons at low levels of coverage. Further, the estimate of the relative abundance of a transcript can substantially disagree, even when coverage levels are high. This may be due to the low sampling fraction and if so, it will persist as an issue needing to be addressed in experimental design even as the next wave of technology produces larger numbers of reads. We provide practical recommendations for dealing with the technical variability, without dramatic cost increases.</p

A new framework for assessing the contributions of professionals in the natural sciences

No abstract available

Neoliberalisation and 'lad cultures' in higher education

This paper links HE neoliberalisation and ‘lad cultures’, drawing on interviews and focus groups with women students. We argue that retro-sexist ‘laddish’ forms of masculine competitiveness and misogyny have been reshaped by neoliberal rationalities to become modes of consumerist sexualised audit. We also suggest that neoliberal frameworks scaffold an individualistic and adversarial culture among young people that interacts with perceived threats to men’s privilege and intensifies attempts to put women in their place through misogyny and sexual harassment. Furthermore, ‘lad cultures’, sexism and sexual harassment in higher education may be invisibilised by institutions to preserve marketability in a neoliberal context. In response, we ask if we might foster dialogue and partnership between feminist and anti-marketisation politics

Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression.

Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of GLUT4 to the cell surface. Here we examined the origins of intercellular heterogeneity in insulin signaling. Akt activation alone accounted for ~25% of the variance in GLUT4, indicating that additional sources of variance exist. The Akt and GLUT4 responses were highly reproducible within the same cell, suggesting the variance is between cells (extrinsic) and not within cells (intrinsic). Generalized mechanistic models (supported by experimental observations) demonstrated that the correlation between the steady-state levels of two measured signaling processes decreases with increasing distance from each other and that intercellular variation in protein expression (as an example of extrinsic variance) is sufficient to account for the variance in and between Akt and GLUT4. Thus, the response of a population to insulin signaling is underpinned by considerable single-cell heterogeneity that is largely driven by variance in gene/protein expression between cells