THE EFFECTS OF GENETIC ANCESTRY AND SOCIOCULTURAL FACTORS ON PULMONARY TUBERCULOSIS SUSCEPTIBILITY IN NORTHEASTERN MEXICO

Genetic and environmental factors contribute to variation in tuberculosis (TB) disease risk among individuals in the Americas, although the relative contribution of each of these factors remains unclear. Genetic ancestry may serve as a proxy for underlying genetic differences in TB risk between the European, Native American, and African groups that formed many populations in the Americas, but this has never been tested. Such tests are complicated by the fact that genetic ancestry and important potential social predictors of TB are usually confounded. The urban center of Nuevo León, the Monterrey Metropolitan Area (MMA), presents a unique setting to tease apart these predictors. The MMA has excessive rates of TB disease and drug-resistant TB, and it is heterogeneous with respect to potential social predictors of disease risk and genetic ancestry. This dissertation addressed three aims. First, we explored predictors of active TB in the MMA, including genetic ancestry, demographic, and socioeconomic characteristics. Second, we assessed the variability of genetic ancestry in the MMA to determine whether genetic ancestry could potentially capture genetic variants underlying disease risk in the parental populations. Third, we examined social and behavioral predictors of drug-resistant TB in the MMA. Data included detailed demographic and socioeconomic measures and 291,917 genetic markers from 194 individuals with latent TB infection and active pulmonary TB at the University Hospital in Monterrey. We found that diabetes, computer ownership, and marital status predicted active TB. Substantial variation in genetic ancestry was observed, but genetic ancestry was not a risk factor for active TB after controlling for socioeconomic variables. This result indicates that: 1) genetic components of TB disease risk do not vary in the parental populations that formed the MMA, 2) effects of genetic factors are low compared to social factors, or 3) power was too low to detect existing associations. Finally, we found that crack cocaine use predicted drug-resistant TB in this urban context. In conclusion, variation in TB rates across populations may be better understood by addressing population-specific social factors that have larger effects on active TB and drug-resistant TB susceptibility

African American Models of Community Organization: Toward a Culturally Competent Theory

The University Archives has determined that this item is of continuing value to OSU's history.Session 3: Community, Organizations, Culture, and Foster Care. Presenter: Bonnie Young Laing, Ph.D., Virginia Commonwealth University (2003) - "African American Models of Community Organization: Toward a Culturally Competent Theory"The Ohio State University College of Social Wor

A decision framework for systems of systems based on operational effectiveness

Presentation by Bonnie Young, Naval Postgraduate School, Professor, Systems Engineerin

Tachyphylaxis in 12-0-Tetradecanoylphorbol Acetate- and Arachidonic Acid-Induced Ear Edema

12-0-Tetradecanoylphorbol acetate (TPA) applied to mouse ears rapidly induces an edema which is maximal by 6 hr but has substantially waned by 24 hr. (This is in contrast to many inflammatory agents that cause a prolonged edema lasting many days.) Reapplication of TPA at 16-24 hr will not provoke a second edematous response although increased erythema is evident. Arachidonic acid (AA) applied to mouse ears (4 mg) provokes an even more rapid edema which is maximal at 1 hr and has substantially waned by 6 hr. Reapplication of AA at 3-24 hr also will not provoke a second edematous response although, again, increased erythema does result. Pretreatment of ears with AA results in inhibition of the edema response to subsequent application of TPA, and TPA pretreatment moderately inhibits a subsequent response to AA. TPA-induced edema can be delayed by agents such as naproxen, an inhibitor of AA cyclooxygenase. In contrast, AA-induced edema is inhibited only by agents, such as phenidone, that inhibit both cyclooxygenase and lipoxygenase. The data suggest that the edemas result from interaction of the products of the cyclooxygenase and lipoxygenase pathways of AA metabolism. The lack of secondary edema response appears to be related to the inability of TPA or AA to reinduce vascular permeability. The effect is specific to AA and TPA; responses to xylene or anthralin are unaffected by TPA or AA pretreatment. It is postulated that the tachyphylactic effects observed involve lipoxygenase metabolites of AA

Exercise Makes You Feel Good, But Does Feeling Good Make You Exercise?: An Examination of Obese Dieters

Whereas exercise-induced mood enhancement has been well documented, the relationship between mood and exercise participation is less well understood. Mood states influence evaluative judgments that could plausibly influence a decision to exercise. Further, most exercise-mood research is limited to normal weight adults in response to a single exercise session. The current investigation examines the influence of (a) morning mood on exercise, (b) exercise intensity/duration on mood enhancement, and (c) daily change in mood on exercise days compared with nonexercise days in obese behavioral weight loss program (BWLP) participants. Participants (N=36) recorded morning, evening, and pre- and postexercise mood, as well as the type, duration, and intensity of exercise. Within-person analyses indicated that (a) morning mood was associated with an increased likelihood of exercising, (b) mood ratings were higher following exercise of greater intensity and duration, and (c) daily mood enhancement was associated with greater exercise initiation and greater exercise intensity. Measuring mood before and after exercise may yield important clinical information that can be used to promote physical activity in obese adults

Dominance-related seasonal song production is unrelated to circulating testosterone in a subtropical songbird

AbstractCirculating testosterone (T) is widely considered to play a key role in the production of sexual displays by male vertebrates. While numerous studies support a role for circulating T in promoting the production of song in male birds, this understanding is based primarily on evidence from seasonally breeding northern temperate species, leaving it unclear whether this mechanism generalizes to other regions of the world. Here we investigate whether variation in circulating levels of T can explain the marked within- and among-individual variation in male song performance observed in a subtropical population of the year-round territorial white-browed sparrow weaver (Plocepasser mahali mahali). Our findings reveal that both circulating T and male song production peaked at a similar time point, halfway through the population-level breeding season. However, while dominant males were more likely to sing and sang for longer than subordinate males, within-group paired comparisons revealed no dominance-related differences in circulating T. Moreover, comparisons both among and within individual dominant males revealed that song duration, syllable rate and proportion of time spent singing were all unrelated to circulating T. Together, our findings suggest that natural variation in male song production, at least in this population of white-browed sparrow weavers, is achieved principally through mechanisms other than variation in circulating T concentration. More widely, our results are in line with the view that male song production is not exclusively regulated by gonadally synthesized steroids

The Nutrition Education Initiative Resource Guide: Examining Effectiveness with Middle School Students and Perceptions of Science Teachers

Background and Purpose: With obesity in children and youth continuing to be a major health problem in the U.S., schools are considered an important setting to implement programs to address the issue but few have focused on middle school students. The purposes of this study were to: 1) determine the effectiveness of a school-based nutrition education program, the Nutrition Education Initiative (NEI) Resource Guide, in improving school lunch eating behaviors of middle school students, and 2) identify science teachers’ perceptions of the materials. Implementation: The project was implemented by 16 middle school science teachers and 309 seventh grade students in a medium-sized north Florida community. The NEI Guide included three conceptual areas (Build a Healthy Base, Choose Sensibly and Aim for Fitness), major concepts, objectives, narrative information, and teaching strategies. Evaluation: Using a pre-/post without control group design, the study involved collecting data via food recall surveys with students, and surveys and interviews with teachers. Data were analyzed using descriptive statistics and paired t-tests. Results: During lunch time, a higher proportion of students met the recommended dietary servings for dairy, meat, vegetables, fruit, juice and grains from pre-test to post-test. Students also significantly increased dietary intake of meat (p< .01), fruit (p< .01) and fruit/juice combined (p< .05); and significantly decreased intake of fried vegetables (p< .001), with decreased fat intake approaching significance (p< .06). Differences in dietary patterns were noted between the two schools studied. Science teachers perceived the NEI Guide as effective; yet they also identified challenges including lack of adequate training, lack of time to implement the materials, and lack of collaboration with the project team. Conclusion: The project outcomes suggest that middle school science teachers can positively impact school lunch eating behaviors of middle school students in selected schools by incorporating nutrition education in their curricula

Building Public Issues Education Capacity to Address Health and Wellness: Recommendations from a Survey of Extension Professionals

A national Web-based survey administered through the University of Maryland assessed Cooperative Extension\u27s involvement in public policy education specific to health and wellness. Respondents included Family Consumer Sciences administrators, faculty, and staff. The majority of respondents agreed that public policy education was within the scope of their responsibilities, critical to their programs, and helpful in raising citizens\u27 interest and commitment to healthier communities. However, public policy education efforts would benefit from a more integrated approach across the national Extension system in terms of policy focus and Extension professionals\u27 roles and level of involvement

Leadership Training for Oral Health Professionals: A Call to Action

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153632/1/jddj002203372012762tb05245x.pd