ajnmmi1106003

Abstract: Molecular imaging allows direct visualization of targets and characterization of cellular pathways, as long as a high signal/background ratio can be achieved, which requires a sufficient amount of probes to accumulate in the imaging region. The Asn-Gly-Arg (NGR) tripeptide selected by phage display can specifically target tumor vasculature. Recognizing the aminopeptidase N (APN or CD13) receptor on the membrane of tumor cells, the peptide can be further internalized into cytoplasma by the endosomal pathway. Hence NGR can serve as an ideal candidate for tumor imaging, once it is conjugated with fluorescent or radiolabeled imaging probes. Herein, we highlight some recent developments of NGR peptide based imaging of tumors. Although still in the preliminary stage, some NGR probes have shown potential as promising agents in future clinical applications

Aggregation-Induced Emission (AIE), Life and Health

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health

Gamma-AApeptides with potent and broad-spectrum antimicrobial activity

The present invention is directed to a novel class of antimicrobial agents called .gamma.-AApeptides. The current invention provides various categories of .gamma.-AApeptides, for example, linear .gamma.-AApeptides, cyclic .gamma.-AApeptides, and lipidated .gamma.-AApeptides. .gamma.-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. .gamma.-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed .gamma.-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms

γ-AApeptides with potent and broad-spectrum antimicrobial activity

The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms

Ligand-Controlled Monoselective <i>C</i>‑Aryl Glycoside Synthesis via Palladium-Catalyzed C–H Functionalization of <i>N</i>‑Quinolyl Benzamides with 1‑Iodoglycals

A monoselective synthesis of aryl-<i>C</i>-Δ^1,2-glycosides from 1-iodoglycals via palladium-catalyzed <i>ortho</i>-C–H activation of <i>N</i>-quinolyl benzamides has been developed. An amino acid derivative was used as a crucial ligand to improve the yield and monoselectivity of the coupling reaction. The utility of this protocol was demonstrated by a concise synthesis of key moieties of some natural products