ツインブロック装置装着後の脳活動

ツインブロック装置(TBA)の装着による不快感および下顎の前方移動量の増加が前頭葉前部皮質の活動を上昇させるという仮説を立て、これらを検証した。対象は、II級1類不正咬合の顔貌を有する男性10名(II級群)と正常咬合を有する男性10名(I級群)とした。TBAを装着しない場合と装着して下顎を前方へ0、2、4、6、8mm移動させた場合において、ガム咀嚼を20秒間課し、この間の前頭葉前部皮質における酸化ヘモグロビンレベルを光トポグラフィ装置によって計測した。さらに、視覚的評価スケール(VAS)によって快・不快感を定量化した。その結果、TBAの装着によって酸化ヘモグロビンレベルが両群ともに上昇すること、群間の有意差はないこと、下顎を前方移動させても変化はないことが明らかになった。また、TBAを装着して前方移動させると、VASによって示される不快感は増した

ABO Blood Incompatibility Positively Affects Early Graft Function: Single-Center Retrospective Cohort Study

Background We investigated the association between ABO-incompatible (ABO-I) kidney transplantation and early graft function. Methods We retrospectively analyzed 95 patients who underwent living donor kidney transplantation between May 2009 and July 2019. It included 61 ABO-compatible (ABO-C) and 34 ABO-I transplantations. We extracted data on immunologic profile, sex, age, cold ischemic time, type of immunosuppression, and graft function. Two definitions were used for slow graft function (SGF) as follows: postoperative day (POD) 3 serum creatinine level >3 mg/dL and estimated glomerular filtration rate (eGFR) Results The characteristics between the ABO-C and ABO-I were not different. ABO-I received rituximab and plasma exchange. Patients also received tacrolimus and mycophenolate mofetil for 2 weeks and prednisolone for 1 week before transplantation as preconditioning. Of the 95 study patients, 19 (20%) and 21 (22%) were identified with SGF according to POD 3 serum creatinine level or eGFR, respectively. Multivariable analysis revealed that ABO-I significantly reduced the incidence of SGF (odds ratio, 0.15; 95% confidence interval, 0.03-0.7; P = .02), and cold ischemic time >150 min increased the incidence of SGF (odds ratio, 6.5; 95% confidence interval, 1.7-25; P = .006). Similar results were identified in POD 3 eGFR. Inferior graft function in patients with SGF was identified up to 6 months after transplantation. Conclusion ABO-I reduces the incidence of SGF, which is associated with an inferior graft function up to 6 months

Feasible kidney donation with living marginal donors, including diabetes mellitus

Objectives: To compare the donor outcomes of living donor kidney transplantation between standard donors (SDs) and marginal donors (MDs) including diabetic patients (MD + DM). Methods: MDs were defined according to Japanese guideline criteria: (a) age >70-years, (b) blood pressure 25 to = 70 to 6.2 or Results: No kidney function parameters were different between SDs and MDs. When comparing SD and MD + DM, MD + DM had a lower postoperative eGFR (48 vs. 41 (1 (month), p = .02), 49 vs. 40 (12, p = 2 risk factors. Conclusions: Although long-term observation of donor kidney function is necessary, careful MD + DM selection had the potential to expand the donor pool

Childhood leukemia in relation to residential radon and other radiation: a case-control study in Japan

ASA conference on radiation and health, 200

Airborne and waterborne radon concentrations in houses with the use of groundwater

6th International Conference on High Levels of Natural Radiation and Radon Area

Residential radon and childhood leukemia: a meta-analysis of published studies

6th International Conference on High Levels of Natural Radiation and Radon Area