Decreased Prostaglandin E2 Production by Inflammatory Cytokine and Lower Expression of EP2 Receptor Result in Increased Collagen Synthesis in Keloid Fibroblasts

We investigated the metabolism of arachidonic acid in normal skin-derived fibroblasts (NF) as well as in keloid-derived fibroblasts (KF) in response to macrophage migration inhibitory factor (MIF), a pluripotent cytokine. We found that MIF enhanced cyclooxygenase-2 activity in NF more than in KF. Consistent with this finding, prostaglandin E2 (PGE2), an antifibrogenic molecule, was more significantly increased in NF than in KF by MIF treatment. As regarding E prostanoid receptor 2, the level of expression was significantly lower in KF than in NF. On the other hand, Forskolin, a direct activator of adenylcyclase, decreased collagen synthesis in both NF and KF, which indicates that cAMP plays an important role in regulating collagen synthesis. As PGE2 induces cAMP production, it is conceivable that increased collagen synthesis in KF might be owing to decreased PGE2 and cAMP production. These findings may aid in the development of a therapeutic strategy for the regulation of collagen synthesis in keloid fibroblasts

Interannual to Decadal Variations of Submesoscale Motions around the North Pacific Subtropical Countercurrent

The outputs from a submesoscale permitting hindcast simulation from 1990 to 2016 are used to investigate the interannual to decadal variations of submesoscale motions. The region we focus on is the subtropical Northwestern Pacific including the subtropical countercurrent. The submesoscale kinetic energy (KE) is characterized by strong interannual and decadal variability, displaying larger magnitudes in 1996, 2003, and 2015, and smaller magnitudes in 1999, 2009, 2010, and 2016. These variations are partially explained by those of the available potential energy (APE) release at submesoscale driven by mixed layer instability in winter. Indeed, this APE release depends on the mixed layer depth and horizontal buoyancy gradient, both of them modulated with the Pacific Decadal Oscillation (PDO). As a result of the inverse KE cascade, the submesoscale KE variability possibly leads to interannual to decadal variations of the mesoscale KE (eddy KE (EKE)). These results show that submesoscale motions are a possible pathway to explain the impact associated with the PDO on the decadal EKE variability. The winter APE release estimated from the Argo float observations varies synchronously with that in the simulation on the interannual time scales, which suggests the observation capability to diagnose the submesoscale KE variability

Spreading of Antarctic Bottom Water examined using the CFC-11 distribution simulated by an eddy-resolving OGCM

We have investigated the spreading and pathway of Antarctic Bottom Water(AABW) using the simulated distribution of chlorofluorocarbons(CFCs) in a global eddy-resolving(1/10°) OGCM. Our goal is understanding of the processes and pathways determining the distribution of CFCs in the Southern Ocean, where much of this tracer is entrained by formation of deep and bottom water. The simu- lated high CFC-11 water reveals the newly formed AABW around the Antarctic Continent. The main source regions of AABW in the model are in the Weddell Sea(60°- 30°W ), offshore of Wilkes Land(120°- 160°E ) and in the Ross Sea(170°E -160°W ). In our model, spreading of simulated CFC-11 in the deep Southern Ocean from the newly formed AABW regions is more similar to the observed distribution than in coarse-resolution models. In the Weddell Sea, the high CFC-11 water spreads eastward with the Antarctic Circumpolar Current(ACC) and flows northward to the Argentine Basin. The high CFC-11 water from Wilkes Land joins with the high CFC-11 water from the Ross Sea. Some of the high CFC-11 water from Wilkes Land flows northward toward New Zealand. The high CFC-11 water from the Ross Sea flows eastward with the ACC along the Mid Ocean Ridge and northward to the Southeast Pacific Basin

Impact of oceanic-scale interactions on the seasonal modulation of ocean dynamics by the atmosphere

Ocean eddies (with a size of 100–300 km), ubiquitous in satellite observations, are known to represent about 80% of the total ocean kinetic energy. Recent studies have pointed out the unexpected role of smaller oceanic structures (with 1–50 km scales) in generating and sustaining these eddies. The interpretation proposed so far invokes the internal instability resulting from the large-scale interaction between upper and interior oceanic layers. Here we show, using a new high-resolution simulation of the realistic North Pacific Ocean, that ocean eddies are instead sustained by a different process that involves small-scale mixed-layer instabilities set up by large-scale atmospheric forcing in winter. This leads to a seasonal evolution of the eddy kinetic energy in a very large part of this ocean, with an amplitude varying by a factor almost equal to 2. Perspectives in terms of the impacts on climate dynamics and future satellite observational systems are briefly discussed

Impact of heavy rains of 2018 in western Japan: disaster-induced health outcomes among the population of Innoshima Island

Southwestern Japan suffered its worst rains in 2018 causing floods and mudslides, claiming 225 lives and forcing millions for evacuations. Referred as "Heisei san-ju-nenshichi-gatsugou", the disaster was the result of incessant precipitation caused by the interaction of typhoon "Prapiroon" with the seasonal rain front "Baiu". The present epidemiological study aims to investigate disaster-induced health issues in 728 residents of Innoshima island in the Hiroshima Prefecture by comparing their clinical data in pre-disaster (2017) and disaster-hit (2018) years which was obtained from annual health screening. Comparison of data showed a significant increase in the urine protein concentration in victims following the disaster. Probing further into the household conditions, showed that a total of 59,844 households were affected with water outage during the heavy rains, which was accompanied by severe damage of sewerage pipelines with complete recovery process taking two weeks. This two weeks of the crisis forced victims to refrain from using restrooms which in turn led to infrequent urination, thereby explaining the increased urine protein concentration in victims following the disaster. The present study addresses the acute health implications caused by the water crisis and serves as a precautionary measure for disaster management council to provide enhanced aftercare services in victims in further events of natural disasters

Japanese language instruciton under MEXT 2008 course of study : Learning for developing students' universe of language through transactions with words of others

本研究は,学習者が自分のまわりの他者と出会いかかわり合うことをとおして,自分自身の言葉の世界を広げ,自らの学びを探究していくことができるようにするための効果的な指導法を開発していくことを目的としている。そこで,小学1年生と小学4年生において,他者の言葉として教科書以外のテキストを位置付け,言葉をとおしたかかわり合いの場を意図的,計画的に設定し,教科書本文との比較をとおして読みを深める実践を試みた。1年生では,教科書と絵本を比べることによって,共通点や相違点に気付き,物語の本質的なおもしろさに迫っていくことができた。4年生では,自分の読みをもたせることを大切にした結果,子どもたちは自分たちの考えと比べて感想や疑問を抱きながら本文を読み,主体的な読みを生み出すことができた。二つの実践をとおして,学年やねらいに応じて他者の言葉を設定することの有効性がわかった。その際,他者の言葉を吟味して選択するとともに,比べ方や比べる視点を明確にすることが必要であると感じた。今後は,他者の言葉として,テキストとともに学習者同士のかかわり合いを,授業の中に効果的に生かすことのできる単元づくりを試みたい