Oblique focus ICCD laboratory evaluation

An oblique focus intensified charge coupled device (ICCD) was constructed and operated in a vacuum system. Special gratings were obtained and an optical system set up to try to model a candidate UV spectrometer (Milieu Interstellaire et Intergalactique-MISIG), and to produce small enough images to test the theoretical subpixel resolution capability of the ICCD system. The efforts were only partly successful. Based on the results, a similar detector was built and flown successfully on a Princeton rocket program

Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth.

Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling molecules in the context of atherosclerosis and inflammation, accumulated evidence indicates that these lipid-signaling molecules can have pleiotropic effects on the fate and function of the immune system. These effects range from the regulation of immune cell survival and proliferation to chemotaxis and antiviral immunity. New studies now indicate that tumor-derived oxysterols can serve to subvert the immune system by recruiting protumorigenic neutrophils into the tumor microenvironment. The consequence of this recruitment is the generation of proangiogenic factors and matrix metalloproteinase proteins that provide a tumor a significant growth and survival advantage. In combination with other recent studies, these data highlight the ongoing cross talk between sterol metabolism and the immune system, and they raise the intriguing possibility that targeting oxysterol pathways could serve as a novel therapeutic approach in the war on cancer

DLAs and Galaxy Formation

Damped Lyman-alpha systems (DLAs) are useful probes of star formation and galaxy formation at high redshift. We study the physical properties of DLAs and their relationship to Lyman-break galaxies using cosmological hydrodynamic simulations based on the concordance Lambda cold dark matter model. Fundamental statistics such as global neutral hydrogen (HI) mass density, HI column density distribution function, DLA rate-of-incidence and mean halo mass of DLAs are reproduced reasonably well by the simulations, but with some deviations that need to be understood better in the future. We discuss the feedback effects by supernovae and galactic winds on the DLA distribution. We also compute the [C_II] emission from neutral gas in high-z galaxies, and make predictions for the future observations by ALMA and SPICA. Agreement and disagreement between simulations and observations are discussed, as well as the future directions of our DLA research.Comment: 15 pages, 10 figures. Invited brief review for Modern Physics Letters A, in pres

High-Redshift Superclustering of QSO Absorption Line Systems on 100 Mpc Scales

We have analyzed the clustering of C IV absorption line systems in an extensive new catalog of heavy element QSO absorbers. The catalog permits exploration of clustering over a large range in both scale (from about 1 to over 300 Mpc) and redshift (z from 1.2 to 4.5). We find significant evidence (5.0 sigma) that C IV absorbers are clustered on comoving scales of 100 Mpc and less --- similar to the size of voids and walls found in galaxy redshift surveys of the local universe --- with a mean correlation function $\xi = 0.42 \pm 0.10$ over these scales. We find, on these scales, that the mean correlation function at low (z=1.7), medium (z=2.4), and high redshift (z=3.0) is $\xi=0.40 \pm 0.17$, $0.32 \pm 0.14$, and $0.72 \pm 0.25$, respectively. Thus, the superclustering is present even at high redshift; furthermore, it does not appear that the superclustering scale, in comoving coordinates, has changed significantly since then. We find 7 QSOs with rich groups of absorbers (potential superclusters) that account for a significant portion of the clustering signal, with 2 at redshift $z\sim 2.8$. We find that the superclustering is just as evident if we take $q_0=0.1$ instead of 0.5; however, the inferred scale of clustering is then 240 Mpc , which is larger than the largest scales of clustering known at present. This discrepancy may be indicative of a larger value of $q_0$, and hence $\Omega_0$. The evolution of the correlation function on 50 Mpc scales is consistent with that expected in cosmologies with density parameter ranging from $\Omega_0 =$ 0.1 to 1. Finally, we find no evidence for clustering on scales greater than 100 Mpc ($q_0=0.5$) or 240 Mpc ($q_0=0.1$).Comment: 16 LaTeX pages with 3 encapsulated Postscript figures included, uses AASTeX (v. 4.0) available at ftp://ftp.aas.org/pubs/ , to appear in The Astrophysical Journal Letter

Experimental validation of the mechanical coupling response for hygro-thermally curvature-stable laminated composite materials

Stacking sequence configurations for hygro-thermally curvature-stable (HTCS) laminates have recently been identified in 9 classes of coupled laminate with standard ply angle orientations +45, "1245, 0 and 9

Pruning the Lyman alpha forest of Q1331+170

A multitude of absorption lines seen shortward of QSO Ly-alpha emission, that cannot be traced to heavy element absorption systems, are assumed to be Ly-alpha lines arising in intervening clouds. Studies of these Ly-alpha clouds, typically done at 1 A or lower resolution, have shown N(H1) approximately equal to 10(exp 13) - 10(exp 17) sq cm and b approximately equal to 35 km/s. Sargent et al 1980, on the basis of a flat pair velocity correlation function (PVCF), argued that these clouds are intergalactic. But Crotts 1989 showed that the strong Ly-alpha lines are spatially clustered. High resolution studies of Webb 1987 and Rauch et al 1992 also report some evidence for weak clustering, but overall such high resolution studies have been rare. A study of the Ly-alpha forest of Q1331 + 170 over x(sub abs) = 1.60 - 2.19 based on 18 km/s resolution data at S/N approximately equal to 15, with metal-line deblending incorporated

Properties of the Optokinetic Motor Fibres in the Rock Lobster: Build-Up, Flipback, Afterdischarge and Memory, Shown by Their Firing Patterns

The properties of sets of motor fibres responding to both clockwise and anticlockwise rotation have been studied in the oculomotor nerve of the rock lobster. There are probably three, but perhaps four, units in each set. None of these fibres has statocyst input, but there is weak input onto the tonic fibres from the antennal joints such that the eye turns in the direction toward which the antenna points. Many preparations show bilateral visual input onto all fibres but the degree of coupling between the eyes is very variable, and at times can be nearly totally absent. Depending on the speed of rotation the fibres show a gradual build-up in frequency, during rotation in the preferred direction, interrupted by flipbacks. During the fast stage of the resulting nystagmic movements all agonistic fibres can be completely inhibited and all antagonistic ones can be activated, usually for a period of about 0.5 sec. Fibre activity is demonstrated which appears to underlie an ‘optokinetic memory’ of contrasting target position in the visual field. It consists of (a) very prolonged after-discharges for a stationary striped pattern (b) resumption of discharges at an appropriate frequency after dark periods up to 2 min, and (c) adjustment of such frequencies to changes in stripe position during the dark period. The fibres show habituation to repeated stripe movement but the response can be dishabituated by passive rotation of the animal. The largest visual responses were obtained to intermediate speeds of stripe rotation (about 2°/sec)

Input Sources and Properties of Position-Sensitive Oculomotor Fibres in the Rock Lobster, Panulirus Interruptus (Randall)

Sets of head-up, head-down, eye-up and eye-down motor fibres were studied in the oculomotor nerve of the rock lobster. An eye-withdrawal fibre was also investigated. Apart from the statocyst input, light distribution on the eyes has the strongest influence on the position-sensitive fibres. Weaker optokinetic input from moving targets is also present. Strongly habituating input is obtained from the antennal joints. This input causes orientation of the eye toward the direction in which the antenna points. The same antennule movement in the vertical plane can result in either excitation or inhibition of the head-down fibre, suggesting the presence of two opposing inputs, presumably from the statocysts and basal joint receptors of the antennule. The inputs on to the position-sensitive fibres which indicate body position are such as to stabilize the eye position in space during body movement. The optokinetic and antennal joint inputs are probably involved in tracking and antennal pointing reactions. The eye-withdrawal fibre is stimulated by touch of the head and around the eye, but is inhibited by the excited state

A Survey of Metal Lines at High-redshift (I) : SDSS Absorption Line Studies - The Methodology and First Search Results for OVI

We report the results of a systematic search for signatures of metal lines in quasar spectra of the Sloan Digital Sky Survey (SDSS) Data Release 3(DR3), focusing on finding intervening absorbers via detection of their OVI doublet. Here we present the search algorithm, and criteria for distinguishing candidates from spurious Lyman $\alpha${} forest lines. In addition, we compare our findings with simulations of the Lyman $\alpha${} forest in order to estimate the detectability of OVI doublets over various redshift intervals. We have obtained a sample of 1756 OVI doublet candidates with rest-frame equivalent width > 0.05 \AA{} in 855 AGN spectra (out of 3702 objects with redshifts in the accessible range for OVI detection). This sample is further subdivided into 3 groups according to the likelihood of being real and the potential for follow-up observation of the candidate. The group with the cleanest and most secure candidates is comprised of 145 candidates. 69 of these reside at a velocity separation > 5000 km/s from the QSO, and can therefore be classified tentatively as intervening absorbers. Most of these absorbers have not been picked up by earlier, automated QSO absorption line detection algorithms. This sample increases the number of known OVI absorbers at redshifts beyond z$_{abs} > 2.7 substantially.Comment: 41 pages, 10 figures, 2 tables, accepted by AJ. This is a substantially altered version, including an appendix with details on the validity of the search algorithm on one pixel rather than binning. Also note that M. Pieri was added as autho