689 research outputs found
Industrial Control System Fingerprinting and Anomaly Detection
Part 2: CONTROL SYSTEMS SECURITY International audience Industrial control systems are cyber-physical systems that supervise and control physical processes in critical infrastructures such as electric grids, water and wastewater treatment plants, oil and natural gas pipelines, transportation systems and chemical plants and refineries. Leveraging the stable and persistent control flow communications patterns in industrial control systems, this chapter proposes an innovative control system fingerprinting methodology that analyzes industrial control protocols to capture normal behavior characteristics. The methodology can be used to identify specific physical processes and control system components in industrial facilities and detect abnormal behavior. An experimental testbed that incorporates real systems for the cyber domain and simulated systems for the physical domain is used to validate the methodology. The experimental results demonstrate that the fingerprinting methodology holds promise for detecting anomalies in industrial control systems and cyber-physical systems used in the critical infrastructure.
Document type: Part of book or chapter of boo
Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
AbstractThousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.</jats:p
Godtfredsen syndrome – recurrent clival chondrosarcoma with 6years follow up: a case report and literature review
Background: We report a rare case of Godtfredsen syndrome caused by clival chondrosarcoma and perform a
review of literatures. This article also explains the clinico-anatomical correlation of this rare neurological syndrome.
Case presentation: A 22-year-old gentleman presented with binocular diplopia. Clinical examination revealed an
isolated right abducent nerve and right hypoglossal nerve palsy, with other cranial nerves intact.
Neuroimaging revealed a right clival mass. Supraorbital craniotomy and tumour debulking were done in the same
year. Histopathological examination showed low-grade chondrosarcoma.
After 5-years of default, he came back with the tumour enlarged. He underwent a right orbitozygomatic craniotomy
and tumour excision with 33 cycles of radiotherapy.
Despite two surgeries and radiotherapy, the abducent nerve and hypoglossal nerve did not improve throughout 6 years of follow-up. Cranial nerve VI palsy is not always a false localizing sign, in Godtfredsen syndrome it serves as a localizing sign.
Conclusion: To the best of our knowledge, this is the frst case report of Godtfredsen Syndrome secondary to clival
chondrosarcoma. Cranial nerve VI and XII palsy with no involvement of other cranial nerves, most likely the pathology is located at the clivu
Which is better for gastric cancer patients, perioperative or adjuvant chemotherapy: a meta-analysis
meta-analysis of chemotherapy adverse effects. (A) Nausea and vomit, (B) gastrointestinal problem, (C) liver toxicity, (D) neurologic effects, (E) leukopenia, (F) thrombocytopenia, (G) neutropenia. (TIF 507Â kb
Generation of high-density high-polarization positrons via single-shot strong laser-foil interaction
We put forward a novel method for producing ultrarelativistic high-density
high-polarization positrons through a single-shot interaction of a strong laser
with a tilted solid foil. In our method, the driving laser ionizes the target,
and the emitted electrons are accelerated and subsequently generate abundant
photons via the nonlinear Compton scattering, dominated by the laser.
These photons then generate polarized positrons via the nonlinear
Breit-Wheeler process, dominated by a strong self-generated quasi-static
magnetic field . We find that placing the foil at an
appropriate angle can result in a directional orientation of , thereby polarizing positrons. Manipulating the laser polarization
direction can control the angle between the photon polarization and
, significantly enhancing the positron polarization degree.
Our spin-resolved quantum electrodynamics particle-in-cell simulations
demonstrate that employing a laser with a peak intensity of about
W/cm can obtain dense ( 10 cm) polarized positrons
with an average polarization degree of about 70\% and a yield of above 0.1 nC
per shot. Moreover, our method is feasible using currently available or
upcoming laser facilities and robust with respect to the laser and target
parameters. Such high-density high-polarization positrons hold great
significance in laboratory astrophysics, high-energy physics and new physics
beyond the Standard Model
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