Positive and Negative Ion Motion in Thermal Oxide on Silicon by Radiochemical and MOS ANALYSIS

Metal-oxide-silicon capacitor and radiochemical analyses of anion in sodium contamination failure mod

Sideshow Sounds: Black Bandleaders Respond to Exoticism

Everyone knows P. G. Lowery, broadcaster of African-American music. Less known are those whose sideshow leadership predates that of Lowery. The pioneering entrepreneurial-entertainment legacy of bandleaders like Solomon P. White, J. 0. McNutt, and James Wolfscale set the stage for Lowery\u27s phenomenal success. This presentation investigates their personal histories in the context of mainstream and circus cultures; their indispensable contribution to the success of the circus and the popularization of African-American music; and their role as the sinew of African-American communities through newspaper distribution and correspondence. Black sideshow bands-first documented in 1881 within Milner Library\u27s Circus Route Books Digital Collection, were relegated to the circus annex, constrained by compounding layers of liminality. Sideshows housed those performers labeled as exotic, and musicians were expected to perform as such. This presentation details how Black musicians responded to their forced otherness, highlighting their agency within a confined stage. Through ingenious spectacles, they deployed the marketing of exoticism onto the audience\u27s desire for the novel and the authentic. Possessing both musical and managerial skills, they utilized their market share to transform themselves from employees to autonomous business owners. This research was conducted for the digital humanities exhibit, Agency through Otherness: Portraits of Performers in Circus Route Books 1875-1925. The exhibit is the final segment of the Council on Library and Information Resources grant project, Step Right Up: Digitizing Over 100 Years of Circus Route Books with collaborating institutions the Circus World Museum and The Ringling Archives

Korelasi Antara Bobot Badan Induk Dengan Litter Size, Bobot Lahir Dan Mortalitas Anak Kelinci New Zealand White

This study aims to determine the relationship between body weight of does with litter size, birth weight and mortality in New Zealand White (NZW) rabbits. The research was conducted at the Central Breeding and Raising Non Ruminant Livestock unit Balekambang, Surakarta, Central Java. The material used in this study was 35 does that had sexual maturity and have given birth at least once aged maximum 3 years old. In addition, the study also used 7 bucks aged approximately 2 years. Data were analysed using simple linear regression analysis. The study found that the weight of the does had a very weak correlation value to litter size, birth weight and mortality of young rabbits

Bioactive Lipid Coating of Bone Allografts Direct Engraftment and Fate Determination of Bone Marrow-Derived Cells in Rat GFP Chimeras

Bone grafting procedures are performed to treat wounds incurred during wartime trauma, accidents, and tumor resections. Endogenous mechanisms of repair are often insufficient to ensure integration between host and donor bone and subsequent restoration of function. We investigated the role that bone marrow-derived cells play in bone regeneration and sought to increase their contributions by functionalizing bone allografts with bioactive lipid coatings. Polymer-coated allografts were used to locally deliver the immunomodulatory small molecule FTY720 in tibial defects created in rat bone marrow chimeras containing genetically-labeled bone marrow for monitoring cell origin and fate. Donor bone marrow contributed significantly to both myeloid and osteogenic cells in remodeling tissue surrounding allografts. FTY720 coatings altered the phenotype of immune cells two weeks post-injury, which was associated with increased vascularization and bone formation surrounding allografts. Consequently, degradable polymer coating strategies that deliver small molecule growth factors such as FTY720 represent a novel therapeutic strategy for harnessing endogenous bone marrow-derived progenitors and enhancing healing in load-bearing bone defects

Eps15R is required for bone morphogenetic protein signalling and differentially compartmentalizes with Smad proteins

Transforming growth factor β superfamily members signal through Smad transcription factors. Bone morphogenetic proteins (BMPs) act via Smads 1, 5 and 8 and TGF-βs signal through Smads 2 and 3. The endocytic adaptor protein Eps15R, or ‘epidermal growth factor (EGF) receptor pathway substrate 15-related protein’ is a component of EGF signal transduction, mediating internalization of the EGF receptor. We show that it interacts with Smad proteins, is required for BMP signalling in animal caps and stimulates Smad1 transcriptional activity. This function resides in the Asp-Pro-Phe motif-enriched ‘DPF domain’ of Eps15R, which activates transcription and antagonizes Smad2 signalling. In living cells, Eps15R segregates into spatially distinct regions with different Smads, indicating an unrecognized level of Smad compartmentalization

Direct Stimulation Of Human Fibroblasts By nCeO2 In Vitro Is Attenuated With An Amorphous Silica Coating

Background: Nano-scaled cerium oxide (nCeO2) is used in a variety of applications, including use as a fuel additive, catalyst, and polishing agent, yet potential adverse health effects associated with nCeO2 exposure remain incompletely understood. Given the increasing utility and demand for engineered nanomaterials (ENMs) such as nCeO2, “safety-bydesign” approaches are currently being sought, meaning that the physicochemical properties (e.g., size and surface chemistry) of the ENMs are altered in an effort to maximize functionality while minimizing potential toxicity. In vivo studies have shown in a rat model that inhaled nCeO2 deposited deep in the lung and induced fibrosis. However, little is known about how the physicochemical properties of nCeO2, or the coating of the particles with a material such as amorphous silica (aSiO2), may affect the bio-activity of these particles. Thus, we hypothesized that the physicochemical properties of nCeO2 may explain its potential to induce fibrogenesis, and that a nano-thin aSiO2 coating on nCeO2 may counteract that effect. Results: Primary normal human lung fibroblasts were treated at occupationally relevant doses with nCeO2 that was either left uncoated or was coated with aSiO2 (amsCeO2). Subsequently, fibroblasts were analyzed for known hallmarks of fibrogenesis, including cell proliferation and collagen production, as well as the formation of fibroblastic nodules. The results of this study are consistent with this hypothesis, as we found that nCeO2 directly induced significant production of collagen I and increased cell proliferation in vitro, while amsCeO2 did not. Furthermore, treatment of fibroblasts with nCeO2, but not amsCeO2, significantly induced the formation of fibroblastic nodules, a clear indicator of fibrogenicity. Such in vitro data is consistent with recent in vivo observations using the same nCeO2 nanoparticles and relevant doses. This effect appeared to be mediated through TGFβ signaling since chemical inhibition of the TGFβ receptor abolished these responses. Conclusions: These results indicate that differences in the physicochemical properties of nCeO2 may alter the fibrogenicity of this material, thus highlighting the potential benefits of “safety-by-design” strategies. In addition, this study provides an efficient in vitro method for testing the fibrogenicity of ENMs that strongly correlates with in vivo finding