Juvenile Granulosa Cell Tumor with an Unusual Clinical Course: A Late-onset and Late Recurrent Case

Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (～97%) occur in individuals G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested

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MRS Study of ACC in Asperger's Syndrome

Purpose Proton magnetic resonance spectroscopy (1H MRS) is a noninvasive neuroimaging method to quantify biochemical metabolites in vivo and it can serve as a powerful tool to monitor neurobiochemical profiles in the brain. Asperger's syndrome (AS) is a type of autism spectrum disorder, which is characterized by impaired social skills and restrictive, repetitive patterns of interest and activities, while intellectual levels and language skills are relatively preserved. Despite clinical aspects have been well-characterized, neurometabolic profiling in the brain of AS remains to be clear. The present study used proton magnetic resonance spectroscopy (1H MRS) to investigate whether pediatric AS is associated with measurable neurometabolic abnormalities that can contribute new information on the neurobiological underpinnings of the disorder. Methods Study participants consisted of 34 children with AS (2-12 years old; mean age 5.2 (±2.0); 28 boys) and 19 typically developed children (2-11 years old; mean age 5.6 (±2.6); 12 boys) who served as the normal control group. The 1H MRS data were obtained from two regions of interest: the anterior cingulate cortex (ACC) and left cerebellum. Results In the ACC, levels of N-acetylaspartate (NAA), total creatine (tCr), total choline-containing compounds (tCho) and myo-Inositol (mI) were significantly decreased in children with AS compared to controls. On the other hand, no significant group differences in any of the metabolites were found in the left cerebellum. Neither age nor sex accounted for the metabolic findings in the regions. Conclusion The finding of decreased levels of NAA, tCr, tCho, and mI in the ACC but not in left cerebellar voxels in the AS, suggests a lower ACC neuronal density in the present AS cohort compared to controls

A Planar Gas Sensor Combined with Interdigitated Array Electrodes

Generally, the gap and width of the electrodes should be small in order to generate a large number of redox cycles. However, it was difficult to fabricate fine patterns on the gas-permeable membrane, because the membrane was flexible and its surface was not flat. On the other hand, it is already possible to fabricate fine IDA patterns on a hard and flat substrate and are already being marketed. However, if these electrodes fabricated on substrate are set in an electrolyte solution, they do not come into contact with the membrane. Therefore, it is said that the sensitivity and response speed are poor. Accordingly, we experimented with a new method of applying IDA electrodes to a gas-sens ing system. We call it a planar IDA gas sensor. A piece of filter paper containing an electrolyte solution was put on IDA electrodes, which were fabricated on a glass substrate. This gas sensor was very easy to construct. A similar planar sensor had been reported for amperometric sensing of oxygen.9 It was developed as a low-cost and disposable sensor, and applied to glucose sensing. A planar sensor is expected to be more useful in complicated detection systems i.e. using IDA electrodes, which was confirmed after being used in a hydrogen-detection system

Evaluation Tendency of Experienced Child Care Providers on the Appropriateness of Manner of Speaking by Current Child Care Providers and Students to 3-Year-Old Children —Focusing on Reflection, Evaluation, Interpretation, and Meaning Making—

The purpose of this study was to clarify the evaluation tendency of experienced caregivers on the appropriateness of manner of speaking by current caregivers and students, who were interacting with 3 -year-old children with "desirable attitude" and "attitude needs consideration". We analyzed evaluations by a former public kindergarten director who had worked for 36 years and a child care provider who had worked at a private kindergarten for 15 years and had no experience in a supervisory position. In both evaluations, a similar trend was found for the "attitude needs consideration". However, there was a discrepancy between the two in terms of the “desirable attitude”. This result suggests that reflection, evaluation criteria, interpretation, and meaning making based on childcare experience are more important in capturing "manner of speaking" for "attitude needs consideration”.departmental bulletin pape

イギリスの初等教育 : 1988年から2011年の文化的文脈における教育政策と教育実践

What can we learn from policy change? What can we learn about primary schools and primary teaching by understanding the dynamics of recent change? This lecture will present an account and an analysis of changes in policy and practice over the last twenty years in Britain. It will also discuss the continuing process of change and current policy trends following a recent change of government. The session will encourage students to reflect on comparisons between Japan and Britain as a way of understanding the social, economic and political factors that inform primary education. The session will be arranged in three sections: 1. Curriculum - national curriculum and the needs of primary children - citizenship, health and welfare - assessment and testing 2. Teachers - teacher qualification and professional development - teacher autonomy and teaching methods - teachers and other adults in the classroom 3. School governance - variety of types of primary school - local accountability - national accountabilit

子どもたちの生活の向上 : 1997年から2011年の政策と施行

The incoming ‘New Labour’ government in Britain in 1997 promoted educational attainment as its top policy priority. But by 2003 this priority had a wider focus on improving outcomes for all children – in terms of their health, safety and general well-being, as well as education and training for work. The lecture will describe the wide programme of policy initiatives introduced by the Labour government to improve children’s lives, and the changes made by the Coalition Government from May 2010. It will examine how these have impacted on local authorities, schools and other services for children. The session will also encourage students to relate the above to social policy in Japan. How do policies shape the way that services are provided to children and families? The session will be arranged in three sections: 1. Integrating children’s services - national policy - role and experience of Local Authorities (LAs) - influencing practice of professionals working with children 2. Childcare, parenting and provision - expansion of childcare through legislation - children’s centres - extended schools 3. Child protection and vulnerable children - child abuse - vulnerable groups - children in poverty - children in care - disabled children - children in trouble with the la