Cremation Novel that Describes the Life of the Female Scavengers Who Destroyed the Characters

Our society is developing and growing fast in all aspects like civilization, scientific knowledge and economy. But it is a fact that a particular division of people in the society is still suffering and they are not able to come out from their dejected situation of life considered as the underclass people. A compass in the ship is a device which helps the sailor to show the directions and guides him to reach the shore safely when he is in the mid of the sea. Likewise, literature is a device which guides the good path to the people who lives in this universe. Literature is like a glass which reflects on the society. and it is also called as the treasury vault for our civlized culture. In Tamil literature, the novels register the congregation’s history. Most of the novels throws a light on the happenings of realism. but the novels majorly focus on the overall biological life of the underclass people by detailing their cultural positions, social existence, habituation, relationship status, professional system and their problems. this research paper or essay analyses on the life of the cremators, whose entries are very rarely unseen and updated among this novel

Feminist thoughts on Rajam Krishnan's literary trajectory

Man and woman are two equal beings in God's creation. Both beings make up human society. One of the highest qualities of humanity is to respect man as a human being. But male society does not even regard woman as an equal being. The struggles faced by women in life, social problems and social denial are the reasons for the emergence of feminist thoughts. Women face difficulties at various levels in their lives. Lack of education, disenfranchisement, marital difficulties, dowry problems, chastity and widowhood are some of the problems faced by women. It is found in women's lives. Removing these shortcomings will lead to social change. This article examines these issues through feminist criticism

Structural Equation Modelling (SEM) Approach On Inappropriate Construction Equipment Delay Factors

The advancement of construction equipment is a trend in the construction industry, with numerous benefits. However, using inappropriate construction equipment causes delays in construction projects, affecting the firm's reputation. A number of research studies on overall delay have been conducted globally. Even so, there is a lack of research on construction delays caused by inappropriate construction equipment. The aim of this paper is to investigate the inappropriate construction equipment delay factors and their effects on the firm's reputation. Based on the issues identified in the focus group interviews and the literature survey, a questionnaire survey was conducted to assess the impact of these factors on the progress of Indian construction projects. The primary constraint was that all 300 responses were collected in person from construction professionals to avoid lethargic responses that could skew the results. Pearson correlation coefficients were used to determine the positive strength of each factor's relationship. A t-test was used to see if there was a significant difference between the respondents' firm categories. Structural Equation Modeling (SEM) was used to validate the effective relationship between the causes of delays due to inappropriate construction equipment and its impact on company's reputation. All of the factors examined by the SEM analysis evidenced that the inappropriate construction equipment factors are correlated among themselves and combined to impact the reputation of the company. Recommendations are made to overcome the inappropriate equipment delay factors. Doi: 10.28991/cej-2021-03091717 Full Text: PD

Semantics of Non-Deterministic Repairable Fault Trees

Fault Tree Analysis is a popular technique used to support the design of critical systems. In a prior work, fault tree semantics have been developed for Non-Deterministic Dynamic FaultTrees that introduces non-determinism to the recovery actions to solve the problem of spare races and improve system reliability. However the existing work only deals with permanent faults. The focus of the thesis work is extending the formalism of NonDeterministic Dynamic Fault Trees to support the notion of repair and develop semantics for Non-Deterministic Repairable Fault Trees to achieve higher availability of system. It includes formalizing the gate semantics and adapting the algorithms for analyzing the fault tree. Furthermore, the thesis work also adapts the minimization algorithms to produce a more compact version of the Recovery Automaton with fewer state

Association of Osteopontin Gene Single Nucleotide Polymorphism with Systemic Lupus Erythematosus.

Systemic lupus erythematosus (SLE) is a prototype autoimmune Disease and is characterized by the presence of autoantibodies which Target self antigens. SLE is commoner in women than men by nearly ten Times, and is typically seen in women of child- bearing age1.Genome Screening studies done in twins have shown the significance of genetic Factors and multiple loci of interest 2. A number of candidate genes Susceptibility to SLE have been identified. The occurence of the disease In monozygotic twins is approximately 25–50%3. This clearly suggests That genetic factors do play a key role in the pathogenesis of the disease. Environmental factors like sunlight, certain drugs, infections may Precipitate the disease in susceptible individuals. Abnormalities in the Activation and maturation of T and B lymphocyte leads to the production Of autoantibodies, which cause multiple organ damage. Lupus nephritis Is the most frequent and potentially serious complication of SLE. Osteopontin(OPN) or early T lymphocyte activation 1(Eta-1) a Member of T helper 1 cytokine plays a key role in the pathogenesis of SLE4 and Lupus nephritis. Osteopontin gene is located on the long arm of Chromosome 4, consisting of 7 exons. OPN mediates its Immunoregulatory effects by enhancing the proinflammatory T-helper1 Cell response and by inhibiting the T- helper 2 responses 5,6. It also Stimulates B lymphocytes to express multiclone antibodies. Increased Serum levels of Osteopontin is detected in patients with SLE 7and Increased OPN expression is found in SLE patients with lupus Nephritis8,9. A number of haplotype analysis shows the association of Osteopontin gene polymorphisms and SLE. Similarly, Wong et al10 has Found significantly higher plasma OPN levels compared to healthy Controls. In this study, the association of osteopontin gene in exon 7 at Position 9250 C T single nucleotide polymorphism (SNP) with SLE Was investigated

In Vitro Anticancer Activity of Ethanolic Extract of Euphorbia hirta (L.)

In the present study, In vitro anticancer effects of Euphorbia hirta were investigated. The objectives of this study are to find the presence of secondary metabolites by preliminary phytochemical investigation and FTIR analysis in the Euphorbia hirta. Ethanolic leaf extract of Euphorbia hirta was tested for its cytotoxicity against Dalton Lymphoma Ascites (DLA) and Ehrlich Ascites Carcinoma (EAC) cell lines using preliminary screening technique (Trypan Blue method and standard MTT colorimetric method). The Euphorbia hirta leaf extract was found to be more cytotoxic against Ehrlich Ascites Carcinoma cell lines when compared to cytotoxic activity against Dalton Lymphoma Ascites cell lines where as 59.67% cytotoxicity were noticed against Ehrlich Ascites Carcinoma cell lines. Extract of Euphorbia hirta showed a dose-dependent reduction of proliferation and induction of apoptosis in the Carcinoma cell lines cells. Ethanolic leaf extract of Euphorbia hirta showed potent cytotoxic activity against DLA and EAC cell lines and its IC50 value was found to be 560.83ìg/ml and 384.7 ìg/ml of extract respectively. The in vitro outcomes of Euphorbia hirta extract showed potent anticancer effect against both DLA and EAC cell lines

Analysis of phytochemical constituents and antibacterial activity of Wrightia tinctoria: traditional medicinal plant of India for application on wound dressing materials

48-54Wrightia tinctoria, an important traditional medicinal plant is exploited for treating several diseases. The study intends to reveal the presence of phytochemicals and test the antibacterial activity of W. tinctoria leaf extracts on nonwoven fabrics to find its suitability for wound dressings. The methodology includes identification and collection of W. tinctoria leaves, preparation of leaf powder, determination of physicochemical analysis, extraction using different solvents, preliminary phytochemical screening, quantitative estimation of phytoconstituents, yield of the extracts and determination of antibacterial activity on plant extract treated fabrics. Results revealed the presence of more active metabolites in the ethanol plant extract of W. tinctoria leaves which may be the reason for the promising antibacterial potential against the bacterial strains. As a promising ethnomedicinal plant, W. tinctoria may serve as a major source of useful drugs finding its suitability for developing wound dressings

Homologs of Circadian Clock Proteins Impact the Metabolic Switch Between Light and Dark Growth in the Cyanobacterium Synechocystis sp. PCC 6803

The putative circadian clock system of the facultative heterotrophic cyanobacterial strain Synechocystis sp. PCC 6803 comprises the following three Kai-based systems: a KaiABC-based potential oscillator that is linked to the SasA-RpaA two-component output pathway and two additional KaiBC systems without a cognate KaiA component. Mutants lacking the genes encoding the KaiAB1C1 components or the response regulator RpaA show reduced growth in light/dark cycles and do not show heterotrophic growth in the dark. In the present study, the effect of these mutations on central metabolism was analyzed by targeted and non-targeted metabolite profiling. The strongest metabolic changes were observed in the dark in ΔrpaA and, to a lesser extent, in the ΔkaiAB1C1 mutant. These observations included the overaccumulation of 2-phosphoglycolate, which correlated with the overaccumulation of the RbcL subunit in the mutants, and taken together, these data suggest enhanced RubisCO activity in the dark. The imbalanced carbon metabolism in the ΔrpaA mutant extended to the pyruvate family of amino acids, which showed increased accumulation in the dark. Hence, the deletion of the response regulator rpaA had a more pronounced effect on metabolism than the deletion of the kai genes. The larger impact of the rpaA mutation is in agreement with previous transcriptomic analyses and likely relates to a KaiAB1C1-independent function as a transcription factor. Collectively, our data demonstrate an important role of homologs of clock proteins in Synechocystis for balanced carbon and nitrogen metabolism during light-to-dark transitions

Degradation of aflatoxin B1 from naturally contaminated maize using the edible fungus Pleurotus ostreatus

Aflatoxins are highly carcinogenic secondary metabolites that can contaminate approximately 25% of crops and that cause or exacerbate multiple adverse health conditions, especially in Sub-Saharan Africa and South and Southeast Asia. Regulation and decontamination of aflatoxins in high exposure areas is lacking. Biological detoxification methods are promising because they are assumed to be cheaper and more environmentally friendly compared to chemical alternatives. White-rot fungi produce non-specific enzymes that are known to degrade aflatoxin in in situ and ex situ experiments. The aims of this study were to (1) decontaminate aflatoxin-B-1-(AFB(1)) in naturally contaminated maize with the edible, white-rot fungus Pleurotus ostreatus (oyster mushroom) using a solid-state fermentation system that followed standard cultivation techniques, and to (2) and to assess the risk of mutagenicity in the resulting breakdown products and mushrooms. Vegetative growth and yield characteristics of P. ostreatus were not inhibited by the presence of-AFB(1).-AFB(1) was degraded by up to 94% by the Blue strain. No aflatoxin could be detected in P. ostreatus mushrooms produced from-AFB(1)-contaminated maize. Moreover, the mutagenicity of breakdown products from the maize substrate, and reversion of breakdown products to the parent compound, were minimal. These results suggest that P. ostreatus significantly degrades-AFB(1) in naturally contaminated maize under standard cultivation techniques to levels that are acceptable for some livestock fodder, and that using P. ostreatus to bioconvert crops into mushrooms can reduce-AFB(1)-related losses.University of Arizona Green Fund [GF 15.31]Open Access Journal.This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]